2019
DOI: 10.1186/s12916-019-1305-x
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Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort

Abstract: Background Multimorbidity is associated with higher mortality, but the relationship with cancer and cardiovascular mortality is unclear. The influence of demographics and type of condition on the relationship of multimorbidity with mortality remains unknown. We examine the relationship between multimorbidity (number/type) and cause of mortality and the impact of demographic factors on this relationship. Methods Data source: the UK Biobank; 500,769 participants; 37-73 ye… Show more

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Cited by 168 publications
(176 citation statements)
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“…Think coronary heart disease or breast cancer, haematology or gastroenterology. But the cumulative effect of several diseases often involves interactions that make the practical and medical impacts of the combination much greater than the sum of their parts 16 .…”
Section: Better Togethermentioning
confidence: 99%
“…Think coronary heart disease or breast cancer, haematology or gastroenterology. But the cumulative effect of several diseases often involves interactions that make the practical and medical impacts of the combination much greater than the sum of their parts 16 .…”
Section: Better Togethermentioning
confidence: 99%
“…As people dying from COVID-19 are predominantly older and have pre-existing LTCs [5][6][7] , some have speculated that many of these people would have soon died of other causes and that life expectancy may therefore not being greatly impacted 8,9 . While multimorbidity, the presence of multiple LTCs, is known to be associated with increased mortality 10 , people with multimorbidity nonetheless can be expected to live for many years 11 . Raw counts of deaths may therefore mislead policy-makers and the public, causing them to either over-or under-estimate the total impact of COVID-19 related deaths.…”
Section: Introductionmentioning
confidence: 99%
“…The two largest studies of specific multimorbidity groups in the UK have used UK Biobank data where participants are healthier (i.e. less multimorbid), smoke and drink less and are from less socioeconomically deprived areas than the overall population [12][13][14]. Second, most previous studies have focused on older populations (aged 60+); few have provided age-stratified clusters [10,11,15], leaving scarce evidence for the younger multimorbid population.…”
Section: Introductionmentioning
confidence: 99%