Relationship Between Multiple Sclerosis and Intestinal Dysbiosis: An Integrative Review

Abstract

The aim of the present study is to provide a better understanding of the relationship between MS and intestinal dysbiosis, which may lead to new strategies for the prevention and treatment of the disease. Methodology: Integrative review on the relationship between MS and intestinal dysbiosis, PubMed and Scopus databases were used, considering articles published in the last 5 years. Nine studies were included to compose the collection. Results: The results of recent studies suggest that intestinal dysbiosis may be associated with the development of MS, since the intestinal microbiota plays an important role in modulating the immune system. They discuss possible mechanisms by which intestinal dysbiosis can lead to MS, including activation of immune cells and production of pro-inflammatory cytokines. Conclusion: It can be suggested that treatment with probiotics, prebiotics and other interventions aimed at modulating the intestinal microbiota may represent a promising approach in the treatment of multiple sclerosis.