Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb

Burkholder, Thomas J.; Fingado, B.; Baron, Stéphanie; Lieber, Richard L.

doi:10.1002/jmor.1052210207

Cited by 466 publications

(434 citation statements)

References 32 publications

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“…The basis of differential muscle atrophy in the posterior and anterior compartment muscles is not clear. Both muscles are primarily fast muscles, with 87% of fibers from medial gastrocnemius and 100% of fibers from tibialis anterior being fast-twitch glycolytic or fast-twitch oxidative glycolytic (8). Interestingly, decreased atrophy of tibialis anterior compared to medial gastrocnemius muscle was also observed following spinal cord isolation in a previous study (28) and the authors suggested that this was related to higher basal activity (as measured by 24-hour EMG) of medial gastrocnemius compared to tibialis anterior.…”

Section: Discussionmentioning

confidence: 87%

Magnetic resonance imaging of mouse skeletal muscle to measure denervation atrophy

Zhang

Morrison

et al. 2008

Experimental Neurology

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We assessed the potential of different MRI measures to detect and quantify skeletal muscle changes with denervation in two mouse models of denervation/neurogenic atrophy. Acute complete denervation and chronic partial denervation were examined in calf muscles after sciatic nerve axotomy and in transgenic SOD1 G93A mice, respectively. Serial T 2 , diffusion tensor, and high resolution anatomical images were acquired, and compared to behavioral, histological, and electrophysiological data. Increase in muscle T 2 signal was first detected after sciatic nerve axotomy. Progressive muscle atrophy could be monitored with MRI-based volume measurements, which correlated strongly with postmortem muscle mass measurements. Significant increase in muscle fractional anisotropy and decreases in secondary and tertiary eigenvalues obtained from diffusion tensor imaging (DTI) were observed after denervation. In SOD1 G93A animals, muscle denervation was detected by elevated muscle T 2 and atrophy in the medial gastrocnemius at 10 weeks. Changes in T 2 and muscle volume were first observed in medial gastrocnemius and later in other calf muscles. Alterations in secondary and tertiary eigenvalues obtained from DTI were first observed in tibialis anterior and medial gastrocnemius muscles at age 12 weeks. We propose that MRI of skeletal muscle is a sensitive surrogate outcome measure of denervation atrophy in animal models of neuromuscular disorders, with potential applicability in preclinical therapeutic screening studies in rodents. KeywordsMRI; denervation; muscle atrophy; muscle size; nerve injury; SOD1 Neurogenic muscle atrophy is a common accompaniment of neuromuscular disorders affecting motor neurons, motor spinal roots, and peripheral nerves. Muscle size and/or function are frequently used to monitor neuromuscular diseases clinically as well as in disease models. Transgenic mice are often used as preclinical models of neuromuscular disorders. With the availability of various therapeutic interventions that are ready for preclinical evaluation of neuromuscular disorders, including motor neuron disease and neuropathies, there is increasing *Correspondence to: Jiangyang Zhang, Ph.D, Address: Department of Radiology, Johns Hopkins University School of Medicine, 217 Traylor Bldg, 720 Rutland Ave., Baltimore, MD, 21205, USA, Email: jzhang3@jhmi.edu, Kazim A. Sheikh, MD, Address: Department of Neurology, Johns Hopkins University School of Medicine, 600 N-Wolfe street/509 Pathology Bldg., Baltimore, MD 21205, USA, Tel: 410-614-1196, Fax: 410-502-5459, Email: ksheik@jhmi.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimer...

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Section: Discussionmentioning

confidence: 87%

Magnetic resonance imaging of mouse skeletal muscle to measure denervation atrophy

Zhang

Morrison

et al. 2008

Experimental Neurology

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“…Type I and type IIa fibers have high insulin sensitivity and express high levels of GLUT4, whereas type IIb fibers have low insulin sensitivity and GLUT4 expression (Henriksen et al 1990;James et al 1989). In previous reports, the soleus muscle was composed mainly of type I fibers, and the EDL muscle was composed of type IIa and IIb fibers (Burkholder et al 1994;Hirai et al 2011). Thus, the soleus muscle is rich in oxidative fiber, and the EDL muscle is high in glycolytic fiber.…”

Section: Ir Mrna Expression and Akt Phosphorylation By Fx In Soleus Amentioning

confidence: 98%

Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A mice

2012

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Fucoxanthin (Fx) isolated from Undaria pinnatifida suppresses the development of hyperglycemia and hyperinsulinemia of diabetic/obese KK-A y mice after two weeks of feeding 0.2% Fx-containing diet. In the soleus muscle of KK-A y mice that were fed Fx, glucose transporter 4 (GLUT4) translocation to plasma membranes from cytosol was promoted. On the other hand, Fx increased GLUT4 expression levels in the extensor digitorum longus (EDL) muscle, although GLUT4 translocation tended to increase. The expression levels of insulin receptor (IR) mRNA and phosphorylation of Akt, which are in upstream of the insulin signaling pathway regulating GLUT4 translocation, were also enhanced in the soleus and EDL muscles of the mice fed Fx. Furthermore, Fx induced peroxisome proliferator activated receptor  coactivator-1 (PGC-1), which has been reported to increase GLUT4 expression, in both soleus and EDL muscles. These results suggest that in diabetic/obese KK-A y mice, Fx improves hyperglycemia by activating the insulin signaling pathway, including GLUT4 translocation, and inducing GLUT4 expression in the soleus and EDL muscles, respectively, of diabetic/obese KK-A y mice.

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“…Although other physical parameters such as muscle mass and volume and other metabolic parameters such as fiber type distribution substantially influence contractile properties, none predicts muscle function as well as muscle architecture [3,19]. Architectural data, particularly in humans, are used extensively to model muscle-joint behavior [4] and to make surgical decisions [16].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the purposes of this study were to (1) generate a high-fidelity data set that defines the architectural properties of each major human lower extremity muscle; (2) to define the individual muscles with the largest force-generating and excursion capacity across the entire lower extremity; (3) to define the muscle groups with the largest force-generating and excursion capacity at each joint; and (4) to understand the fundamental design features of muscle groups and individual muscles that allow them to perform the specific tasks required for movement.…”

Section: Introductionmentioning

confidence: 99%

Are Current Measurements of Lower Extremity Muscle Architecture Accurate?

Ward¹,

Eng²,

Smallwood³

et al. 2008

Clin Orthop Relat Res

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583

657

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Skeletal muscle architecture is defined as the arrangement of fibers in a muscle and functionally defines performance capacity. Architectural values are used to model muscle-joint behavior and to make surgical decisions. The two most extensively used human lower extremity data sets consist of five total specimens of unknown size, gender, and age. Therefore, it is critically important to generate a high-fidelity human lower extremity muscle architecture data set. We disassembled 27 muscles from 21 human lower extremities to characterize muscle fiber length and physiologic cross-sectional area, which define the excursion and force-generating capacities of a muscle. Based on their architectural features, the soleus, gluteus medius, and vastus lateralis are the strongest muscles, whereas the sartorius, gracilis, and semitendinosus have the largest excursion. The plantarflexors, knee extensors, and hip adductors are the strongest muscle groups acting at each joint, whereas the hip adductors and hip extensors have the largest excursion. Contrary to previous assertions, two-joint muscles do not necessarily have longer fibers than single-joint muscles as seen by the similarity of knee flexor and extensor fiber lengths. These high-resolution data will facilitate the development of more accurate musculoskeletal models and challenge existing theories of muscle design; we believe they will aid in surgical decision making.

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Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb

Cited by 466 publications

References 32 publications

Magnetic resonance imaging of mouse skeletal muscle to measure denervation atrophy

Magnetic resonance imaging of mouse skeletal muscle to measure denervation atrophy

Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A mice

Are Current Measurements of Lower Extremity Muscle Architecture Accurate?

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