Relationship between neurocognitive functioning and episode recurrences in bipolar disorder

Martino, Diego Javier; Strejilevich, Sergio; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; Teitelbaum, Julia; Caravotta, Pablo

doi:10.1016/j.jad.2012.11.037

Cited by 49 publications

(27 citation statements)

References 46 publications

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“…The above results from cross‐sectional studies contrast with some findings from other populations. A small longitudinal study did not find that the experience of successive episodes is related to a progressive neurocognitive decline . This study suggested that neurocognitive impairment could be the cause rather than the consequence of poorer clinical course .…”

Section: Resultsmentioning

confidence: 62%

Areas of controversy in neuroprogression in bipolar disorder

Passos

Mwangi

Vieta

et al. 2016

Acta Psychiatr Scand

185

103

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Illness trajectories are largely variable, and illness progression is not a general rule in BD. The number of manic episodes seems to be the clinical marker more robustly associated with neuroprogression in BD. However, the majority of the evidence came from cross-sectional studies that are prone to bias. Longitudinal studies may help to identify signatures of neuroprogression and integrate findings from the field of neuroimaging, neurocognition, and biomarkers.

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Section: Resultsmentioning

confidence: 62%

Areas of controversy in neuroprogression in bipolar disorder

Passos

Mwangi

Vieta

et al. 2016

Acta Psychiatr Scand

185

103

View full text Add to dashboard Cite

show abstract

“…The seven studies reviewed by Young and colleagues included only two studies that evaluated euthymic patients, and no study discriminated between EOBD and LOBD. Some newer studies with better methodology confirmed the presence of significant cognitive dysfunction in euthymic OABD, but did not support worsening of previous cognitive dysfunction or faster cognitive decline in old age . However, it should be emphasized that these were relatively short‐term studies, with a follow‐up period of 1–3 years.…”

Section: Resultsmentioning

confidence: 95%

“…Recent reports using an extensive cognitive battery have compared LOBD versus EOBD. Patients with LOBD had more extensive neurocognitive impairments in spite of the differences in chronicity, including neurocognitive domains such as the Boston Naming Test (69,95,102). The worse cognitive outcomes observed for LOBD versus EOBD support the view that different etiological mechanisms might be involved.…”

Section: Cognitionmentioning

confidence: 88%

A report on older‐age bipolar disorder from the International Society for Bipolar Disorders Task Force

et al. 2015

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Objectives In the coming generation, older adults with bipolar disorder (BD) will increase in absolute numbers as well as proportion of the general population. This is the first report of the International Society for Bipolar Disorder (ISBD) Task Force on Older-Age Bipolar Disorder (OABD). Methods This task force report addresses the unique aspects of OABD including epidemiology and clinical features, neuropathology and biomarkers, physical health, cognition, and care approaches. Results The report describes an expert consensus summary on OABD that is intended to advance the care of patients, and shed light on issues of relevance to BD research across the lifespan. Although there is still a dearth of research and health efforts focused on older adults with BD, emerging data has brought some answers, innovative questions, and novel perspectives related to the notion of late onset, medical comorbidity, and the vexing issue of cognitive impairment and decline. Conclusions Improving our understanding of the biological, clinical, and social underpinnings relevant to OABD is an indispensable step in building a complete map of BD across the lifespan.

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“…78,79 These studies had a relatively small number of BD patients included (n = 50-110) and used variable cut-off scores, such as scoring 1-2 SD below controls or scoring at or below the fifth percentile. [78][79][80][81][82][83] Findings of these studies suggest that around 40% of patients with BD have no neurocognitive deficits at all and other patients have variable levels of cognitive deficits. 79,83 Studies using strict cut-off scores (such as 2 SD below) found that 25-30% of patients with BD had severe cognitive deficits.…”

Section: Heterogeneity Of Cognitive Impairment In Bd and Schizophrenimentioning

confidence: 99%

“…Several studies have categorized BD patients into cognitively impaired and unimpaired groups based on arbitrary cut‐off scores . These studies had a relatively small number of BD patients included ( n = 50–110) and used variable cut‐off scores, such as scoring 1–2 SD below controls or scoring at or below the fifth percentile . Findings of these studies suggest that around 40% of patients with BD have no neurocognitive deficits at all and other patients have variable levels of cognitive deficits .…”

Section: Heterogeneity Of Cognitive Impairment In Bd and Schizophreniamentioning

confidence: 99%

Differences in cognitive impairment between schizophrenia and bipolar disorder: Considering the role of heterogeneity

Bora

2016

Psychiatry Clin Neurosci

105

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Schizophrenia is associated with significant cognitive impairment. Bipolar disorder (BD) also presents with cognitive deficits that are similar to, albeit less severe, than those reported in schizophrenia. There has been controversy over whether selective deficits in social cognition or developmental trajectory of cognitive deficits can distinguish schizophrenia from BD. Also, available studies have not generally considered the potential effect of cognitive heterogeneity within the two disorders on between-group differences. The current review examines the evidence on the specificity of social cognitive deficits and early neurocognitive impairment to schizophrenia and explores the overall outcome of studies investigating within and cross-diagnosis cognitive heterogeneity in schizophrenia and BD. Current evidence does not support the specificity of social cognitive impairment to schizophrenia. Available studies also suggest that cognitive impairment in premorbid and early stages is evident not only in schizophrenia but also in many BD patients. Both schizophrenia and BD have a number of cognitive subgroups, including severe impairment, good functioning, and one or more selective or modest impairment clusters. While both disorders are represented in each cognitive subgroup, there are significant cross-diagnostic differences regarding prevalences of individuals belonging to the severe impairment and good functioning subgroups. Individuals with schizophrenia are much more likely to exhibit severe cognitive impairment than individuals with BD and good cognitive functioning is more often observed in BD patients than schizophrenia patients. Further identification of the neurobiological and genetic characteristics of the cognitive subgroups in major psychoses can improve the validity of diagnostic systems and can advance the development of personalized management approaches, including cognitive remediation.

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Relationship between neurocognitive functioning and episode recurrences in bipolar disorder

Cited by 49 publications

References 46 publications

Areas of controversy in neuroprogression in bipolar disorder

Areas of controversy in neuroprogression in bipolar disorder

A report on older‐age bipolar disorder from the International Society for Bipolar Disorders Task Force

Differences in cognitive impairment between schizophrenia and bipolar disorder: Considering the role of heterogeneity

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