Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension

Abstract

ObjectiveEpicardial fat tissue thickness (EFT) and the neutrophil/lymphocyte ratio (NLR) are associated with atherosclerosis. Few studies have focused on the relationship between these parameters in patients with newly diagnosed hypertension. In this study, we examined the relationship between EFT and the NLR in patients with newly diagnosed hypertension detected by 24-hour ambulatory blood pressure monitoring (ABPM).MethodsEighty consecutive patients without chronic illness who were diagnosed with hypertension according to ABPM results and 80 otherwise healthy subjects were enrolled in the study. EFT of each participant was measured echocardiographically. The C-reactive protein (CRP) concentration and NLR were measured from venous blood samples.ResultsThe 24-hour average systolic blood pressure was significantly higher in the hypertension group than in the control group (143±17 vs. 117±7 mmHg, respectively). There were no significant differences in age, sex, or body mass index between the two groups. EFT, the NLR, and the CRP concentration were significantly higher in the hypertension group than control group. Additionally, a significantly positive correlation between EFT and the NLR was found in both the control group and hypertension group.ConclusionA higher EFT and NLR were detected in patients with newly diagnosed hypertension than in healthy subjects.

Neutrophil to Lymphocyte Ratio is Increased and Associated with Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children.

“…In the current study, we found the neutrophil counts and NLR were signi cantly higher in hypertension children than healthy children, and the elevated NLR may re ect the upregulation of overall in ammatory and stress status in these children. Likewise, Derya et al found that NLR is increased in newly diagnosed hypertension adults and associated positively with low-grade in ammation indicator C-reactive protein levels [32], which is consistent with our ndings.…”

“…The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocytes (LMR) and platelet-to-lymphocyte ratio (PLR) were proposed as the inexpensive, easily accessible and widely available in ammatory markers. They have been shown to be related to cardiovascular diseases in adults, including atherosclerosis [9], heart failure [10], acute coronary syndromes [11], and hypertension [12].…”

Neutrophil to Lymphocyte Ratio Is Increased and Associated With Left Ventricular Diastolic Function in Newly Diagnosed Essential Hypertension Children

“…In the current study, we found that the neutrophil counts and NLR were significantly higher in hypertension children than in healthy children, and the elevated NLR may reflect the upregulation of overall inflammatory and stress status in these children. Likewise, Derya et al found that NLR is increased in newly diagnosed hypertension adults and associated positively with low-grade inflammation indicator C-reactive protein levels (13), which is consistent with our findings.…”

Environmental Tobacco Smoke Exposure Estimated Using the SHSES Scale and Epicardial Adipose Tissue Thickness in Hypertensive Patients

“…Chang et al performed a study on 214 non-obese patients hospitalized with acute or chronic non-cardiogenic illness and found that EAT thickness was independently correlated with hypertension, age, and BMI [ 35 ]. Moreover, in another study on 80 patients who were diagnosed with hypertension EAT thickness showed a significant correlation with 24-h SBP ( r = 0.434, p < 0.001) [ 36 ]. Nevertheless, the exact mechanism of this correlation requires additional research and the issue whether the EAT is an independent risk factor for hypertension or just coexists as a result of mutual risk factors is yet to be determined.…”