Relationship Between Neutrophil to Lymphocyte Ratio and Slow Coronary Flow

Doğan, Mehmet; Akyel, Ahmet; Çi̇men, Tolga; Bi̇lgi̇n, Murat; Sunman, Hamza; Kasapkara, Hacı Ahmet; Arslantaş, Uğur; Yayla, Kadriye Gayretli̇; Açıkel, Sadık; Yeter, Ekrem

doi:10.1177/1076029613498814

Cited by 33 publications

(30 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, Dogan et al presented that the NLR was higher in SCF group than the healthy controls in contrast to our study [30]. In this study, we did not find any correlation between NLR and TFC in SCF group consistent with Cingoz et al study [30].…”

Section: Discussionsupporting

confidence: 79%

The evaluation of relationship between neutrophil-to-lymphocyte ratio and slow

Ertürk¹

2013

DicleMedj

View full text Add to dashboard Cite

Objective: The aim of this study was to investigate the correlations between leukocyte counts, the neutrophil-tolymphocyte ratio (NLR), and slow coronary flow (SCF). Methods:We evaluated 135 patients undergoing coronary angiography (CAG) within coronary artery disease (CAD) indication. We divided patients into three groups according to the CAG findings. Group 1 consisted of 45 patients with an SCF pattern; group 2 consisted of 45 patients with at least 50% lumen narrowing in at least one epicardial coronary artery; and group 3 (control group) consisted of 45 patients with normal coronary arteries. The quantification of the coronary flow was assessed using the thrombolysis in myocardial infarction (TIMI) frame count method for each of the coronary arteries. Blood samples were collected from the patients after a 12 h overnight fasting. The NLR ratio was calculated from the automated complete blood count.Results: NLR in CAD was higher than in both the SCF and control groups (p=0.008, p<0.001, respectively). However, there was no statistically significant difference between SCF and control group (p=0.768). Neutrophil counts in CAD were higher than in both SCF and control groups, but only the difference between CAD and SCF groups was statistically significant (p=0.010). Conclusion:Our study revealed that circulating neutrophil counts and NLR were related to the coronary artery disease, as expected.Key words: Neutrophil-to-lymphocyte ratio, leukocyte subtype, slow coronary flow, coronary artery disease ÖZET Amaç: Çalışmamızda yavaş koroner akım (SCF) ile nöt-rofil/lenfosit oranı (NLR) ve lökosit alt tipleri arasındaki ilişkiyi araştırmayı amaçladık.Yöntemler: Çalışmaya; koroner arter hastalığı şüphesiy-le koroner anjiyografisi yapılan toplam 135 hasta alındı. Hastalar koroner anjiyografisi sonucuna göre üç gruba ayrıldı: yavaş koroner akım saptanan 45 hasta grup 1, en az bir koroner arterinde 50% ve üzerinde darlık saptanan 45 hasta grup 2 ve normal koroner arterlere sahip 45 kişi ise grup 3'e (kontrol grubu) dahil edildi. Koroner yavaş akım tanısı her bir koroner arterin TIMI kare sayısı hesaplanarak kondu. Tüm hastalardan 12 saatlik açlık sonrası kan örnekleri alındı. NLR oranı tam kan sayımından faydalanılarak hesaplandı.Bulgular: Nötrofil/lenfosit oranı koroner arter hastalığına sahip olanlarda, yavaş koroner akım ve kontrol grubuna göre anlamlı olarak daha yüksekti (sırasıyla p=0,008 ve p<0,001). Fakat NLR oranı yavaş koroner akım ve kontrol grubunda benzer bulundu (p=0.768). Nötrofil sayıları koroner arter hastalığı grubunda SCF ve kontrol grubuna göre daha yüksekti, ancak sadece koroner arter hastalığı ve yavaş koroner akım grubu arasındaki fark istatistiksel olarak anlamlıydı (p=0,010). Sonuç: Çalışmamızda

show abstract

Section: Discussionsupporting

confidence: 79%

The evaluation of relationship between neutrophil-to-lymphocyte ratio and slow

Ertürk¹

2013

DicleMedj

View full text Add to dashboard Cite

show abstract

“…Furthermore, the levels of intercellular adhesion molecule-1, vascular cellular adhesion molecule, and E-selectin levels were also found to be higher in patients with SCF correlating with TFC [5]. In addition, findings that elevated levels of leukocytes and NLR are present in patients with SCF strengthen the argument that inflammation plays a significant role in the development of SCF [16,17]. NGAL is a 25 kDa glycoprotein belonging to the lipocalin family.…”

Section: Discussionmentioning

confidence: 79%

The relationship between neutrophil gelatinase-associated lipocalin levels and the slow coronary flow phenomenon

Aksan

Soylu²,

Aksoy³

et al. 2014

Coronary Artery Disease

View full text Add to dashboard Cite

show abstract

“…Likewise, systemic inflammation has been reported to be a major contributor in many cardiovascular conditions and is associated with different clinical settings which may be involved in the development of SCF. 5,19 Li et al 20 demonstrated that the levels of CRP and interleukin 6 were elevated in patients with SCF. Barutcu and colleagues 21 also reported that inflammatory marker like high-sensitivity CRP may be associated with pathogenesis of SCF or at least in part contributes to its pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Increased Platelet to Lymphocyte Ratio is Related to Slow Coronary Flow

et al. 2015

Self Cite

View full text Add to dashboard Cite

Previous studies showed that both inflammation and platelets have a role in development of slow coronary flow (SCF). Platelet to lymphocyte ratio (PLR) as an emerging inflammatory indicator was significantly associated with adverse cardiovascular events. Therefore, we aimed to assess the relationship between PLR and SCF. Patients who had angiographically normal coronary arteries were enrolled in this retrospective study (n ¼ 221 as SCF group and n ¼ 293 as control group). Patients who had thrombolysis in myocardial infarction frame counts (TFC) above the normal cutoffs were considered to have SCF. Both PLR and C-reactive protein (CRP) were significantly higher in the SCF group. In correlation analysis, PLR has a significantly positive correlation with the left anterior descending artery TFC (P ¼ .001), circumflex artery TFC (P < .001), right coronary artery TFC (P < .001), and serum CRP level (P < .001). In multiple logistic regression analysis, PLR was independently associated with presence of SCF (odds ratio: 1.014, P < .001). In conclusion, higher PLR levels were significantly and independently related to the presence of SCF. Besides, PLR was positively correlated with serum CRP level as a conventional marker for systemic inflammation.

show abstract

Relationship Between Neutrophil to Lymphocyte Ratio and Slow Coronary Flow

Cited by 33 publications

References 18 publications

The evaluation of relationship between neutrophil-to-lymphocyte ratio and slow

The evaluation of relationship between neutrophil-to-lymphocyte ratio and slow

The relationship between neutrophil gelatinase-associated lipocalin levels and the slow coronary flow phenomenon

Increased Platelet to Lymphocyte Ratio is Related to Slow Coronary Flow

Contact Info

Product

Resources

About