Relationship Between Non-contrast Computed Tomography Imaging Markers and Perihemorrhagic Edema Growth in Intracerebral Hemorrhage

Li, Yu-Lun; Lv, Xin‐Ni; Xiao, Wei; Yang, Wen‐Song; Li, Rui; Deng, Lan; Miao, Weiwei; Li, Qi; Lv, Fajin

doi:10.1007/s12028-021-01188-2

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…After irregular shape of hematoma was verified to be a factor associated with PHE growth, few study has focused on the effect of hematoma density on the development of PHE. In our study, NCCT imaging markers, which reflect the heterogeneous density of hematoma, were also capable of promoting early PHE development [15]. The result proved that early PHE growth could be predicted by some characteristics of hematoma, which presenting as different NCCT imaging markers, such as blend sign, black hole sign and island sign.…”

Section: Mini Review | Open Accesssupporting

confidence: 54%

Advances in Prediction for Perihematomal Edema Growth in Intracerebral Hemorrhage

Li¹,

Lv²

2023

Neurodegener Dis Cur Res

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Perihematomal edema (PHE) has been represented as an important secondary injury after intracerebral hemorrhage (ICH). The evolution of PHE contributed to mass effect, which could induce the increase of intracranial pressure. The volume of PHE increased rapidly in the early stage of ICH and continued to increase for 7 to 11 days after symptom onset, and the edema extension distance (EED) increased rapidly within 24 hours, accounting for 60% of the peak EED [1-2]. For the timepoint of follow-up CT scans was different, the fastest development stage of PHE could also be 48 or 72 hours after symptom onset [3-4]. If patients with ICH could not benefit from early surgical evacuation of the hematoma, anti-edema treatment may bring better therapeutic effect. Thus, the use of anti-edema treatment may need to be considered for reducing PHE volume during the early phase of PHE development. How to appropriately predict PHE growth is important in patients at the early stage of ICH.

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Section: Mini Review | Open Accesssupporting

confidence: 54%

Advances in Prediction for Perihematomal Edema Growth in Intracerebral Hemorrhage

Li¹,

Lv²

2023

Neurodegener Dis Cur Res

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“…Notably, however, irregular and relatively minor ICH has a higher relative, not absolute, PHE volume. A recent study showed that certain CT imaging signs, such as the blend sign, black hole sign, and island sign, are capable of predicting hematoma expansion ( 67 ) and are associated with PHE growth in the acute phase of ICH ( 68 ). However, there is currently no evidence supporting an association between hematoma expansion and PHE formation.…”

Section: Risk Factors For Phementioning

confidence: 99%

Perihematomal Edema After Intracerebral Hemorrhage: An Update on Pathogenesis, Risk Factors, and Therapeutic Advances

Chen

Chang

et al. 2021

Front. Immunol.

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Intracerebral hemorrhage (ICH) has one of the worst prognoses among patients with stroke. Surgical measures have been adopted to relieve the mass effect of the hematoma, and developing targeted therapy against secondary brain injury (SBI) after ICH is equally essential. Numerous preclinical and clinical studies have demonstrated that perihematomal edema (PHE) is a quantifiable marker of SBI after ICH and is associated with a poor prognosis. Thus, PHE has been considered a promising therapeutic target for ICH. However, the findings derived from existing studies on PHE are disparate and unclear. Therefore, it is necessary to classify, compare, and summarize the existing studies on PHE. In this review, we describe the growth characteristics and relevant underlying mechanism of PHE, analyze the contributions of different risk factors to PHE, present the potential impact of PHE on patient outcomes, and discuss the currently available therapeutic strategies.

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A machine learning approach for predicting perihematomal edema expansion in patients with intracerebral hemorrhage

et al. 2022

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Relationship Between Non-contrast Computed Tomography Imaging Markers and Perihemorrhagic Edema Growth in Intracerebral Hemorrhage

Cited by 8 publications

References 26 publications

Advances in Prediction for Perihematomal Edema Growth in Intracerebral Hemorrhage

Advances in Prediction for Perihematomal Edema Growth in Intracerebral Hemorrhage

Perihematomal Edema After Intracerebral Hemorrhage: An Update on Pathogenesis, Risk Factors, and Therapeutic Advances

A machine learning approach for predicting perihematomal edema expansion in patients with intracerebral hemorrhage

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