Relationship between novel inflammatory biomarker galectin-3 and depression symptom severity in a large community-based sample

King, Darlene R.; Salako, Damilola C.; Arthur-Bentil, Samia Kate; Rubin, Arielle; Italiya, Jay B.; Tan, Jenny S.; Macris, Dimitri G.; Neely, Hunter K.; Palka, Jayme M.; Grodin, Justin L.; Davis-Bordovsky, Kaylee; Faubion, Matthew; North, Carol S.; Brown, E. Sherwood

doi:10.1016/j.jad.2020.12.050

Cited by 16 publications

(22 citation statements)

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“…Remarkably, previous studies showed the role of Galectin-3, TGF-β, and PAI-1 in the pathophysiology of depression [ 18 – 20 ]. As an instance, a recent study reported that depression in diabetes was linked to higher levels of Galectin-3 [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women

et al. 2021

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Background Previous studies showed the possible association between obesity, dietary pattern, and depressive symptoms. Due to the lack of enough data to confirm the association of obesity and depression in the Middle East, here, we aimed to explore the possible mediatory role of adipokines Galectin-3, transforming growth factor-beta (TGF-β), and endothelial plasminogen activator inhibitor (PAI-1) in the association between low carbohydrate diet (LCD) and depressive symptoms. Methods A total of 256 women aged 17–56 years old were grouped based on their LCD score. Depression anxiety stress scales-21 (DASS-21) self-administered questionnaire was used to evaluate the three negative emotional states of stress, depressive symptoms, and anxiety. Body composition and dietary intake were assessed. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Galectin-3, TGF-β, and PAI-1. Results No significant difference was observed regarding Galectin-3, TGF-β, and PAI-1 levels between the groups with dissimilar adherence to LCD or the groups with different levels of depressive symptoms (P>0.05). However, there was a negative association between LCD score as a covariant and depressive symptoms as an independent variable (P = 0.02) and remarkably, a regression model linear analysis using Galectin-3, TGF-β, and PAI-1 as confounding variables indicated the mediatory role of these adipokines in this association (P>0.05). In other words, adipokines eliminated the significance of the relationship between adherence to LCD and depressive symptoms. Conclusion It seems that higher adherence to LCD is probably associated with a lower prevalence of depressive symptoms in obese adults through the mediatory role of adipokines.

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Section: Discussionmentioning

confidence: 99%

The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women

et al. 2021

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“…Alexithymia has been suggested as a risk factor for depression even though alexithymic features seem to increase during depressive episodes ( 55 , 56 ). Several immuno-inflammatory disturbances have been demonstrated in depressive states such as increased levels of galectin-3 and decreased soluble TWEAK ( 31 , 32 , 41 , 43 ). Galectin-3 not only serves as a biomarker, but is also a contributor to cardiovascular disease and mortality ( 22 , 24 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…Other factors previously linked to cardiovascular disease and mortality are metabolic disturbances (13,33,34), T1D (35), physical inactivity (36), smoking (37), depression (38), and anxiety (39). Depression has also been linked to several inflammatory, metabolic and HPA-axis disturbances (15,31,32,(40)(41)(42)(43)(44), which is also the case for obesity, smoking and physical inactivity (15,36,37,42,45). T1D is an auto-immune disorder characterized by insulindeficiency (46), which is accompanied by several metabolic disturbances (33,34).…”

Section: Introductionmentioning

confidence: 99%

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Galectin-3 Binding Protein, Depression, and Younger Age Were Independently Associated With Alexithymia in Adult Patients With Type 1 Diabetes

et al. 2021

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Aims: Alexithymia has been linked to cardiovascular disease. The aim was to explore whether the immuno-inflammatory variables galectin-3 binding protein (Gal3BP), soluble (s)CD163 and galectin-3 were independently associated with alexithymia, while controlling for known risk factors for cardiovascular disease, such as depression, anxiety, impaired glycemic control, obesity, smoking, and physical inactivity in patients with type 1 diabetes (T1D).Methods: Cross-sectional design. The participants were consecutively recruited from one diabetes out-patient clinic. Alexithymia, depression and anxiety were assessed by self-report instruments. Blood samples, anthropometrics, and blood pressure were collected, supplemented with data from electronic health records. High Gal3BP was defined as ≥3.3 μg/ml, high sCD163 as ≥0.6 μg/ml, high galectin-3 as ≥2.6 ng/ml, impaired glycemic control as HbA1c >70 mmol/mol (>8.6%) and abdominal obesity as waist circumference ≥ 1.02 m for men and ≥ 0.88 m for women.Results: Two hundred and ninety two patients participated (men 56%, aged 18–59 years, alexithymia prevalence 15%). Patients with alexithymia had higher prevalence of depression (34 vs. 6%, p < 0.001), anxiety (61 vs. 30%, p < 0.001), high Gal3BP levels (39 vs. 17%, p = 0.004), high HbA1c levels (46 vs. 24%, p = 0.006), and abdominal obesity (29 vs. 15%, p = 0.045). Depression [adjusted odds ratio (AOR) 6.5, p < 0.001], high Gal3BP levels (AOR 2.4, p = 0.035), and age (AOR 0.96, p = 0.027) were independently associated with alexithymia. Abdominal obesity (AOR 4.0, p < 0.001), high Gal3BP levels (AOR 2.8, p = 0.002), and depression (AOR 2.9, p = 0.014) were associated with high HbA1c. Abdominal obesity and anxiety were associated [Crude odds ratio (COR) 2.4, p = 0.006].Conclusions: T1D patients with alexithymia had higher prevalence of high Gal3BP levels, depression, impaired glycemic control, anxiety, and abdominal obesity, which are known risk factors for cardiovascular disease. Only high Gal3BP levels, depression, and younger age were independently associated with alexithymia in adult patients with T1D.

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“…Galectin-3 is a protein from the group of β-galactoside binding lectins with pro-in ammatory properties, presented as a novel biomarker of pathological conditions, such as various types of cancer, especially thyroid cancer [17], acute and chronic heart failure [26,27], chronic pancreatitis [18], prediabetes state and apparent diabetes [28], depression [29] and many others. It has multiple functions including cells adhesion, in ammation, and extracellular matrix formation, differentiation, proliferation, embryogenesis, and host-pathogen interactions [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Glycation Markers in the Geriatrics Patients

Kuzan

Królewicz

Kustrzeba−Wójcicka

et al. 2021

Preprint

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Background: Medical care for geriatric patients is a great challenge, mainly due to overlapping various deficits relevant to physiologic ageing with numerous coexisting diseases, of which the most common are diabetes mellitus and atherosclerosis. In case of diabetes, glycation process is intensified, which accelerates atherosclerosis development and diabetic complications. Our goal was to investigate the relationship between the classical biochemical parameters of diabetes and atherosclerosis (fasting glucose, glycated hemoglobin (HbA1c), low and high density lipoproteins (LDL, HDL), triglycerides, etc.), as well as parameters which may indicate a nephropathy (creatinine, glomerular filtration rate – GFR), and the parameters strictly related to glycation. Methods: We analyzed the patients' serum concentration of fluorescent glycation products, concentration of soluble receptor for advanced glycation products (sRAGE), lipoprotein receptor-1 (LOX-1), galectin 3 (GAL3), scavenger receptor class A (SR-A) and scavenger receptor class B (SR-BI), as well as the level of lipid peroxidation and free amine content. Results: Among the identified correlations, the most interesting are the following : sRAGE with triglycerides (r = 0.47); sRAGE with SR-BI (r=0.47); SR-BI with LOX-1 (r=0.31), and SR-BI with HDL (r=-0.30). It has been shown that pentosidine and fluorescent AGEs as well as reactive free amine contents are significantly higher in elderly patients with ischemic heart disease. Fluorescent AGEs and pentosidine are also significantly higher in patients with arterial hypertension. The influence of diabetes therapy on parameters related to peroxidation and glycation was also analyzed. Malondialdehyde turned to be higher in patients with diabetes mellitus type 2 not treated with insulin or metformin than in those treated with both medications (p=0.052). GAL3 was found to be lower both in persons without diabetes and in diabetics treated with metformin (p=0.005). LOX1 was higher in diabetic patients not treated with metformin or insulin, and lowest in diabetics treated with both insulin and metformin, with the effect of metformin reducing LOX1 levels (p=0.039). Conclusions: Our results were the basis for a discussion about the diagnostic value in clinial practice of LOX-1 and GAL3 in geriatric patients with diabetes and also provide grounds for inferring the therapeutic benefits of insulin and metformin treatment.

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Relationship between novel inflammatory biomarker galectin-3 and depression symptom severity in a large community-based sample

Cited by 16 publications

References 52 publications

The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women

The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women

Galectin-3 Binding Protein, Depression, and Younger Age Were Independently Associated With Alexithymia in Adult Patients With Type 1 Diabetes

Glycation Markers in the Geriatrics Patients

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