Relationship between nutrition factors and osteopenia: Effects of experimental diets on immature bone quality

Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running

“…Long-term diet-induced obesity reduces the thickness and cross-sectional area of the cortical shell of the femoral neck [40] and tibia [41], significantly reducing the structural properties (loads, energies, stiffness normalized to body weight) [40]. Data from studies of diet-induced obesity suggest that the reductions in structural properties appear due, in part, to changes in trabecular microarchitecture (i.e., increased porosity [42], decreased trabecular number, increased trabecular separation and reduced connectivity [39,43,44] and a shift in trabecular organization from plate-to rod-like, which is reduced in strength [39,45]. The material (size-independent) properties of bone are also affected by high-fat-diet-induced obesity.…”

Bone Metabolism in Obesity and Weight Loss

“…Also, studies show lower bone formation relative to resorption markers in obese compared with leaner populations in adults (27, 126) and children (40). Excess adiposity and a high-fat diet may be particularly detrimental to BMD and bone quality during growth, as demonstrated in rodent studies (24, 128, 190). …”

A Feasibility of Low Intensity Ultrasound Stimulation for Treatment or Prevention of Osteoporosis and Its-Related Fracture

“…Then 3D tetrahedral FE models with 18 µm mesh size were generated using a mass-compensated thresholding technique (Ulrich et al, 1998). Material property of bone (Young's modulus: 12.5 GPa and Poisson's ratio: 0.3) (Kinney et al, 2000;Woo et al, 2009), which was assumed to be isotropic and perfectly elastic, was assigned into the FE models. To analyze FE models, a compressive displacement of an uniaxial 0.5% strain as displacement boundary conditions was applied to the FE models (Woo et al, 2009).…”

“…Material property of bone (Young's modulus: 12.5 GPa and Poisson's ratio: 0.3) (Kinney et al, 2000;Woo et al, 2009), which was assumed to be isotropic and perfectly elastic, was assigned into the FE models. To analyze FE models, a compressive displacement of an uniaxial 0.5% strain as displacement boundary conditions was applied to the FE models (Woo et al, 2009). All FE analyses were performed using the commercial FE software package ABAQUS 6.4 (HKS, Pawtucket, RI, USA).…”