Relationship between obesity and anti‐Müllerian hormone in reproductive‐aged African American women

Abstract

Objective To determine whether there is an association between obesity and Anti-Müllerian hormone (AMH) amongst reproductive-aged African-American women (AAW). Methods 1,654 AAW aged 23–35 who participated in an ongoing NIEHS study were included. Anthropometric measurements, personal health information, and serum AMH and adipokine levels were analyzed. Results The median body mass index (BMI) was 32.4 kg/m2 and the median AMH was 3.18 ng/mL. Participants with obesity had AMH concentrations that were 23.7% lower than those with a BMI ≤ 25 kg/m2 (2.9 ng/mL versus 3.8 ng/mL). In multivariable linear regression models, current BMI (β=−0.015; 95% CI −0.021, −0.009), BMI at age 18 (β=−0.016; 95% CI −0.024, −0.008), heaviest reported lifetime weight (β=−0.002; 95% CI −0.003, −0.001) and leptin (β=−0.016; 95% CI −0.025, −0.007) were inversely associated with AMH. There was no significant association between adiponectin and AMH. AMH was significantly lower (mean log=0.91, SE=0.11) in participants with obesity at age 18 and at enrollment when compared to those who were underweight or normal weight at age 18 but had obesity at enrollment (mean log=1.16, SE=0.12). Conclusions In reproductive-aged AAW there is a significant association between obesity and AMH, suggesting that excess adiposity may compromise ovarian reserve. Effects of obesity on AMH may be cumulative.

The Relationship between Serum Levels of Anti-Mullerian Hormone and Body Mass Index in Adolescents with Polycystic Ovary Syndrome

“…However, Bernardi et al, reported that BMI at the age of 18 (β=-0.016; 95% CI -0.024, -0.008), which is considered the heaviest reported lifetime weight (β=-0.002; 95% CI -0.003, -0.001) was inversely associated with AMH. This difference may be related to different target population as they included premenopausal women of African-American origin [19]. Our study contradicted others who found negative correlation between the two parameters [8,10,19,20].…”

“…This difference may be related to different target population as they included premenopausal women of African-American origin [19]. Our study contradicted others who found negative correlation between the two parameters [8,10,19,20]. Our study reported significant negative correlations between AMH levels and patients' age which was similar to what was reported by others [21].…”

Long-term consequences of obesity on female fertility and the health of the offspring

“…Moreover, among obese women undergoing in-vitro fertilization, obesity adversely affects oocyte quality and uterine receptivity [20,21]. Finally, obesity may adversely affect ovarian reserve [22], a surrogate marker of fertility, and may give rise to luteinizing hormone (LH) surge and corpus luteum dysfunction [23 ■■ ,24,25 ■■ ,26]. Hence, overweight and obese women should be encouraged to lose weight to optimize fertility and pregnancy outcome [11].…”

Ovarian reserve in women with obesity

“…Было выявлено, что у больных ожирением уровень АМГ оказался на 23,7% ниже, чем у больных с ИМТ менее 25 кг/м 2 (2,9 нг/мл против 3,8 нг/мл). В рамках данного исследования ИМТ на момент включения в исследование, ИМТ в возрасте 18 лет, самый высокий вес в течение жизни и уровень лептина отрицательно коррелировали с уровнем АМГ [15].…”

“…Таким образом, по нашим данным, несмотря на то, что для больных ожирением характерны досто-НАУЧНОЕ ИССЛЕДОВАНИЕ верно более низкие значения маркеров овариального резерва, он остается неизмененным по общепринятым критериям. Аналогичные результаты получены и другими авторами, показавшими снижение овариального резерва у женщин с ожирением по сравнению со здоровыми женщинами, однако данные параметры не выходили за пороговые значения для реактива [15]. В планах наших дальнейших исследований: сравнительный анализ овариального резерва у женщин с нарушениями жирового обмена при первичном/ вторичном синдроме поликистозных яичников.…”