Relationship between obesity, diabetes and the risk of thyroid cancer

Oberman, B; Khaku, Aliasgher; Camacho, Fabian; Goldenberg, David

doi:10.1016/j.amjoto.2015.02.015

Cited by 46 publications

(30 citation statements)

References 18 publications

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“…Cancers: Obesity has also been shown recently to play a fundamental role in the development of some types of cancer. Overman et al showed that obesity and type-2 diabetes favors the development of differentiated thyroid cancer -BMI was a strong prognostic variable for differentiated thyroid cancer [43]. Agalliu et al revealed that obesity is strongly related to prostate cancer as compared to the diabetic prostate cancer patients [44].…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Kasprzak

Wojtunik-Kulesza

Oniszczuk

et al. 2018

Natural Product Communications

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Obesity is a common serious health problem leading to many serious health disorders. This phenomenon is defined as the over-storage of lipids in adipose tissue that occurs when there is an imbalance between the energy intake and energy used. During obesity, many metabolic alterations occur that can damage several organs, such as vascular or skeletal muscle resulting in the dysfunction of these tissues. In this review, we will discuss molecular genetics and causes of obesity, some of the disorders related to human obesity as well as anti-obesity tool. An interesting solution to the obesity problem is natural substances, revealing anti-obesity activity, as well as functional food enriched with aforementioned substances. Functional foods are products exhibiting a potentially positive effect on health beyond basic nutrition. They contain well-known biologically active natural compounds, which promote optimal health and reduce the risk of many diseases, including obesity.

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Section: Cardiovascular Diseasementioning

confidence: 99%

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Kasprzak

Wojtunik-Kulesza

Oniszczuk

et al. 2018

Natural Product Communications

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“…Though prognosis of TC is not very poor, it still causes tens of thousands of deaths each year. Family history, radiation exposure, iodine intake abnormality, and obesity are major risk factors [ 4 – 7 ]. Other potential risk factors have not been well investigated.…”

Section: Introductionmentioning

confidence: 99%

Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

Cao

2018

World J Surg Onc

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BackgroundPotential risk of thyroid cancer in patients with inflammatory bowel disease has not been well investigated. The aim of the study was to reveal the relationship between history of inflammatory bowel disease and risk of thyroid cancer.MethodsFirst, 1392 patients with inflammatory bowel disease and 1392 controls were included in a case-control study. All patients did not receive immunosuppressive therapy. A multivariate logistic regression analysis was adopted to determine the relationship between history of inflammatory bowel disease and risk of thyroid cancer. Second, a literature search was performed and eight articles were collected. Pooled odds ratios with 95% confidence intervals were reported for relevant risk estimates in fixed or random effect model.ResultsIn the case-control study, thyroid cancer was more common in patients with inflammatory bowel disease than in controls (P = 0.032). After Bonferroni correction, association of thyroid cancer risk with history of total inflammatory bowel disease or its two subtypes was not found. In the meta-analysis, patients with total inflammatory bowel disease or ulcerative colitis showed an increased risk of thyroid cancer, but patients with Crohn’s disease did not. Furthermore, inflammatory bowel disease patients with immunosuppressive therapy showed an increased risk of the cancer, but patients without immunosuppressive therapy did not have this finding.ConclusionsRisk of thyroid cancer probably elevates in patients with inflammatory bowel disease. Inflammatory bowel disease (particularly ulcerative colitis) itself and use of immunosuppressant might contribute to the development of the cancer.

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“…Our results corroborate with the studies of Dourado et al38 and Mehta et al,39 where in some cases the inflammatory processes caused loss of body mass and inhibition of growth of the adipose tissues. In the studies of Oberman et al40 and Xue and Ideraabdullah,41 mass gain resulting from increased BAI is related to various obesity-associated diseases, such as diabetes mellitus, cardiovascular diseases, cancer, and hyperglycemia. It is known that the composition of the diet offered during the induction of obesity directly influences the development of such diseases since the nutrients act as cellular signal 42,43.…”

Section: Discussionmentioning

confidence: 99%

The administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to cigarette smoke

Peña¹,

Ramos²,

Soares³

et al. 2016

COPD

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This study aimed to evaluate the effects of a high refined carbohydrate diet and pulmonary inflammatory response in C57BL/6 mice exposed to cigarette smoke (CS). Twenty-four male mice were divided into four groups: control group (CG), which received a standard diet; cigarette smoke group (CSG), which was exposed to CS; a high refined carbohydrate diet group (RG), which received a high refined carbohydrate diet; and a high refined carbohydrates diet and cigarette smoke group (RCSG), which received a high refined carbohydrate diet and was exposed to CS. The animals were monitored for food intake and body weight gain for 12 weeks. After this period, the CSG and RCSG were exposed to CS for five consecutive days. At the end of the experimental protocol, all animals were euthanized for subsequent analyses. There was an increase of inflammatory cells in the bronchoalveolar lavage fluid (BALF) of CSG compared to CG and RCSG compared to CG, CSG, and RG. In addition, in the BALF, there was an increase of tumor necrosis factor alpha in RCSG compared to CG, CSG, and RG; interferon gamma increase in RCSG compared to the CSG; and increase in interleukin-10 in RCSG compared to CG and RG. Lipid peroxidation increased in RCSG compared to CG, CSG, and RG. Furthermore, the oxidation of proteins increased in CSG compared to CG. The analysis of oxidative stress showed an increase in superoxide dismutase in RCSG compared to CG, CSG, and RG and an increase in the catalase activity in RCSG compared with CG. In addition, there was a decrease in the glutathione reduced/glutathione total ratio of CSG, RG, and RCSG compared to CG. Therefore, the administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to CS.

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Relationship between obesity, diabetes and the risk of thyroid cancer

Cited by 46 publications

References 18 publications

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Secondary Metabolites, Dietary Fiber and Conjugated Fatty Acids as Functional Food Ingredients against Overweight and Obesity

Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

The administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to cigarette smoke

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