Relationship between obesity‐related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic

Esmaeili, Vahid; Zendehdel, Morteza; Shahverdi, Abdolhossein; Alizadeh, AliReza

doi:10.1111/and.14524

Cited by 7 publications

(3 citation statements)

References 37 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They also reported that waist circumference (WC), waist-to-hip ratio (WHR), skeletal muscle (SM), and visceral fat (VF) did not affect the quality of sperm parameters. Their result was consistent with our study [ 39 ]. Bahar GUR et al also reported that higher VFT (visceral fat thickness) was negatively correlated with sperm normal morphology, but it did not affect sperm progressive motility and sperm concentration.…”

Section: Discussionsupporting

confidence: 94%

“…Several recent studies with interesting results have been conducted since the aforementioned meta-analyses [39][40][41][42]. For example, in a cross-sectional study, Esmaeili et al found that BMI was negatively correlated with normal sperm morphology, sperm total motility, and progressive motility, but it had no effect on sperm volume and concentration.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity is associated with quality of sperm parameters in men with infertility: a cross-sectional study

Darand,

Salimi,

Ghorbani

et al. 2023

Reprod Health

View full text Add to dashboard Cite

Background Previous studies examined the effects of obesity on sperm parameters and reported inconsistent results. Thus, the present study aimed to evaluate the association between obesity and the quality of sperm parameters in infertile men. Material and methods The present cross-sectional study evaluated 218 infertile men aged 20–50. To this end, the 168-item food frequency questionnaire (FFQ) was utilized to evaluate dietary intake. The anthropometric and biochemical variables were examined using standard methods. Further, the association between obesity and the quality of sperm parameters was evaluated using the controlled linear regression for potential confounders. Results The normal sperm morphology had a significant inverse association with BMI [adjusted β − 0.074, CI (− 0.141 to − 0.008), P = 0.029] and WC [adjusted β − 0.026, CI (− 0.051 to − 0.001), P = 0.038]. Additionally, visceral fat had a marginal inverse association with normal sperm morphology [adjusted β − 0.065, CI (− 0.138 to 0.008), P = 0.079] and non-progressive sperm motility [adjusted β − 0.241, CI (− 0.495 to 0.014), P = 0.063]. Conclusion Even though the present results indicated that obesity, abdominal obesity, and visceral fat had inverse associations with normal sperm morphology, more mechanism-based studies should be conducted to confirm these findings.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Obesity is associated with quality of sperm parameters in men with infertility: a cross-sectional study

Darand,

Salimi,

Ghorbani

et al. 2023

Reprod Health

View full text Add to dashboard Cite

show abstract

“…По данным ряда исследователей, уровень общего тестостерона в сыворотке крови и соотношение Т/Э значительно выше у бесплодных мужчин с нормальным индексом массы тела (ИМТ) по сравнению с бесплодными мужчинами, имевшими ожирение (р <0,001), хотя при этом оба показателя не всегда достоверно коррелировали с параметрами эякулята [49][50][51][52].…”

Section: диагностические аспекты обмена эстрогенов: значение соотноше...unclassified

Practical aspects of laboratory monitoring of estrogens in men

Tyuzikov,

Grekov,

Emelyanova

et al. 2023

Androl. genit. hir.

View full text Add to dashboard Cite

Since the discovery of estrogens in the 30s of the XX century, scientific and practical interest in them has been concentrated exclusively from the standpoint of female endocrinology, and the physiology and pathophysiology of estrogens in men, due to the historically established interpretation of the role of these steroids exclusively as female sex hormones, have remained practically unexplored for a long time. However, according to the classical theory of steroidogenesis, estrogens are the end product of this biochemical process, and testosterone, in addition to its well-known independent functions in the male body, also acts as their biochemical precursor. Therefore, normal endocrinology of sex steroids in men is in principle impossible without the participation of estrogens, and over the past decades, convincing scientific data have been accumulated indicating important physiological functions of estrogens in the male body. The review article, based on the literature of recent years, briefly examines the key aspects of clinical endocrinology of estrogens in men and describes in more detail the modern possibilities of methods for laboratory monitoring of estrogens in blood serum in men and some diagnostic tools that allow a more complete and objective interpretation of the results of laboratory methods for determining estrogens, in particular, testosterone/estradiol ratio. It is shown that the calculation of this ratio is a more reliable method for assessing estrogen metabolism disorders in routine clinical practice than the separate determination of serum levels of sex steroids, and can be considered as an important marker of various diseases in men.

show abstract

Association between the weight-adjusted-waist index and testosterone deficiency in adult males: a cross-sectional study

Wang,

Li,

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Testosterone deficiency has been recognized as a significant health concern and is closely related to obesity. The weight-adjusted-waist index (WWI) is an innovative adiposity parameter that is superior to BMI in certain aspects, but its relationship with testosterone levels has not been elucidated. The aim of this study was to investigate the relationships of the WWI with total testosterone levels and testosterone deficiency. Data from the National Health and Nutrition Examination Survey (NHANES, 2011–2016) were utilized. The WWI was calculated as waist circumference (cm) over the square root of weight (kg), and a total testosterone level of less than 300 ng/dL was defined as testosterone deficiency. Weighted multivariable regression models were used to assess the associations. A total of 6859 participants were included, 26.28% of whom were testosterone deficient. The WWI was inversely related to total testosterone levels (β = -49.93, 95% CI: -60.07, -39.78, P < 0.001) and positively associated with testosterone deficiency (OR = 1.46, 95% CI: 1.23, 1.72, P < 0.001) in the fully adjusted model. A significant nonlinear relationship was also detected between WWI and testosterone deficiency (P for nonlinearity = 0.004) with an inflection point of 9.486 cm/√kg. The associations were consistent in the subgroup analysis (all P > 0.05), except for the participants with eGFR < 60 mL/(min*1.73m 2 ) and hypertension. A higher WWI was linked to lower total testosterone levels and a greater risk of developing testosterone deficiency, especially among those who had an eGFR ≥ 60 mL/(min*1.73m 2 ) and were nonhypertensive.

show abstract

Relationship between obesity‐related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic

Cited by 7 publications

References 37 publications

Obesity is associated with quality of sperm parameters in men with infertility: a cross-sectional study

Obesity is associated with quality of sperm parameters in men with infertility: a cross-sectional study

Practical aspects of laboratory monitoring of estrogens in men

Association between the weight-adjusted-waist index and testosterone deficiency in adult males: a cross-sectional study

Contact Info

Product

Resources

About