Relationship between omeprazole pre-treatment and successfull eradication rate on H. pylori (Hp) infection

Caviglia, Renato; Angeletti, Stefano; Luzi, I.; Marignani, Massimo; D’Ambra, G.; Pezzella, Cristina; Paoletti, M.; Annibale, B.; Fave, G. Delle

doi:10.1016/0016-5085(95)22934-5

Cited by 4 publications

(2 citation statements)

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“…Koelz et al (20) reported that in a double-blind randomized trail omeprazole treatment for 2 weeks prior to amoxicillin and omeprazole treatment did not affect the eradication rate of H. pylori. Caviglia et al (7) found similar results when they showed that 2 weeks of pretreatment with omeprazole prior to combination treatment with amoxicillin, metronidazole, and omeprazole did not impair the rate of H. pylori eradication. This is in conflict with a study by Labens et al (21) using amoxicillin and omeprazole.…”

Section: Discussionmentioning

confidence: 75%

Pharmacodynamic effects of antibiotics and acid pump inhibitors on Helicobacter pylori

Sörberg

Hanberger

Nilsson

et al. 1997

Antimicrob Agents Chemother

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Pharmacodynamic studies of Helicobacter pylori exposed to amoxicillin, clarithromycin, metronidazole, omeprazole, and lansoprazole were performed with microscopy, viable count determination, and bioluminescence assay of intracellular ATP. The pharmacodynamic parameters determined were change in morphology, change in cell density, postantibiotic effect (PAE), and control-related effective regrowth time (CERT). The PAE is delayed regrowth after brief exposure to antibiotics or acid pump inhibitors. CERT was defined as the time required for the bacteria to resume logarithmic growth and return to the pre-exposure inoculum in the test culture minus the corresponding time for the control culture. CERT measures the combined effect of initial killing and PAE. There was a good concordance between the bioluminescence assay and viable counts for determining CERT, which makes this parameter useful for pharmacodynamic studies of the effects of antibiotics and acid pump inhibitors on H. pylori. Amoxicillin and metronidazole produced a strong, concentration-dependent initial decrease in CFU per milliliter, but there was a less prominent initial change in intracellular ATP in these cultures. Amoxicillin caused a long PAE when assayed by the bioluminescence assay but no PAE or a negative PAE when assayed by viable count determination. However, amoxicillin showed similar long CERTs with both methods. The pharmacodynamic effects of amoxicillin were concentration dependent up to a maximum response, indicating that concentrations above this level do not increase the antibiotic effect. The PAEs and CERTs of clarithromycin and metronidazole were concentration dependent with no maximum response. With omeprazole and lanzoprazole, there was no PAE or CERT.

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Section: Discussionmentioning

confidence: 75%

Pharmacodynamic effects of antibiotics and acid pump inhibitors on Helicobacter pylori

Sörberg

Hanberger

Nilsson

et al. 1997

Antimicrob Agents Chemother

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“…Therefore, we propose that eradication therapy may be started immediately after prior therapy with an acid inhibitor and without increasing the clarithromycin dose. Our data are supported by the findings of Caviglia et al 19 . and Adamek et al ., 20 who also reported no reduction in eradication rates due to prior antisecretory treatment.…”

Section: Discussionmentioning

confidence: 99%

Influence of clarithromycin dosage on pantoprazole combined triple therapy for eradication of Helicobacter pylori

Ellenrieder

Fensterer

Waurick

et al. 1998

Aliment Pharmacol Ther

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INTRODUCTIONModern eradication treatment of Helicobacter pylori infection requires simple, well tolerated and highly effective therapeutic regimens. These requirements seem at present to be met only by the modern triple therapy, consisting of a proton pump inhibitor in combination with two antiobiotics. 1±4 Per protocol eradication rates have generally been over 90% and acceptable tolerability has been described for both the 14 day standard regimen and the 7-day shortterm therapy. 5±10 The 7-day short-term treatment offers the advantages of fewer side-effects and possibly better compliance, at comparable therapeutic effectiveness. At present, there is much support for the Italian short-term triple therapy with omeprazole (20 mg b.d.) in combination with clarithromycin (250 mg b.d.) and metronidazole or tinidazole (500 mg b.d.). 2,4 Whether the choice of proton pump inhibitor is of importance for the success of bacterial eradication is currently being investigated in several studies.There is a paucity of data regarding the effectiveness of pantoprazole in the triple therapy regimen. 11 Preliminary data suggest that pantoprazole may be substituted for omeprazole without sacri®cing therapeutic ef®c-

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Antibiotic Treatment of Helicobacter pylori Infection

Unge

1999

Gastroduodenal Disease and Helicobacter Pylori

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Relationship between omeprazole pre-treatment and successfull eradication rate on H. pylori (Hp) infection

Cited by 4 publications

References 0 publications

Pharmacodynamic effects of antibiotics and acid pump inhibitors on Helicobacter pylori

Pharmacodynamic effects of antibiotics and acid pump inhibitors on Helicobacter pylori

Influence of clarithromycin dosage on pantoprazole combined triple therapy for eradication of Helicobacter pylori

Antibiotic Treatment of Helicobacter pylori Infection

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