Relationship between optic disc hemorrhage and corneal hysteresis

Radcliffe, Nathan M.; Tracer, Nathaniel; Moraes, Carlos Gustavo V. De; Tello, Celso; Liebmann, Jeffrey M.; Ritch, Robert

doi:10.1016/j.jcjo.2019.10.007

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…They reported that lower baseline CH was associated with faster loss of neuroretinal rim and that for each one mmHg lower baseline CH, the MRW loss was faster by −0.38 µ/year [81]. Radcliffe and colleagues reported that eyes with optic disc hemorrhage-another potentially important sign of glaucoma progression-have significantly lower CH (8.7 mmHg) compared to those without disc hemorrhage (9.2 mmHg) (p = 0.002) [82].…”

Section: Clinical Studies Measuring Corneal Hysteresis and Corneal Re...mentioning

confidence: 99%

Corneal Biomechanical Measures for Glaucoma: A Clinical Approach

Elhusseiny,

Scarcelli,

Saeedi

2023

Bioengineering

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Over the last two decades, there has been growing interest in assessing corneal biomechanics in different diseases, such as keratoconus, glaucoma, and corneal disorders. Given the interaction and structural continuity between the cornea and sclera, evaluating corneal biomechanics may give us further insights into the pathogenesis, diagnosis, progression, and management of glaucoma. Therefore, some authorities have recommended baseline evaluations of corneal biomechanics in all glaucoma and glaucoma suspects patients. Currently, two devices (Ocular Response Analyzer and Corneal Visualization Schiempflug Technology) are commercially available for evaluating corneal biomechanics; however, each device reports different parameters, and there is a weak to moderate agreement between the reported parameters. Studies are further limited by the inclusion of glaucoma subjects taking topical prostaglandin analogues, which may alter corneal biomechanics and contribute to contradicting results, lack of proper stratification of patients, and misinterpretation of the results based on factors that are confounded by intraocular pressure changes. This review aims to summarize the recent evidence on corneal biomechanics in glaucoma patients and insights for future studies to address the current limitations of the literature studying corneal biomechanics.

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Section: Clinical Studies Measuring Corneal Hysteresis and Corneal Re...mentioning

confidence: 99%

Corneal Biomechanical Measures for Glaucoma: A Clinical Approach

Elhusseiny,

Scarcelli,

Saeedi

2023

Bioengineering

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“…Further studies are necessary to confirm such findings. Other recent investigations include the association of lower corneal hysteresis with optic disc hemorrhage [29], and worse visual field severity [30].…”

Section: Corneal Hysteresis As a Risk Factor For Glaucomamentioning

confidence: 99%

Corneal hysteresis: ready for prime time?

Jammal

Medeiros

2022

Current Opinion in Ophthalmology

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Purpose of the reviewThis review summarizes recent findings on corneal hysteresis, a biomechanical property of the cornea. Corneal hysteresis measurements can be easily acquired clinically and may serve as surrogate markers for biomechanical properties of tissues in the back of the eye, like the lamina cribrosa and peripapillary sclera, which may be related to the susceptibility to glaucomatous damage.Recent findingsSeveral studies have provided evidence of the associations between corneal hysteresis and clinically relevant outcomes in glaucoma. Corneal hysteresis has been shown to be predictive of glaucoma development in eyes suspected of having the disease. For eyes already diagnosed with glaucoma, lower corneal hysteresis has been associated with higher risk of progression and faster rates of visual field loss over time. Such associations appear to be stronger than those for corneal thickness, suggesting that corneal hysteresis may be a more important predictive factor. Recent evidence has also shown that cornealcorrected intraocular pressure measurements may present advantages compared to conventional Goldmann tonometry in predicting clinically relevant outcomes in glaucoma.SummaryGiven the evidence supporting corneal hysteresis as an important risk factor for glaucoma development and its progression, practitioners should consider measuring corneal hysteresis in all patients at risk for glaucoma, as well as in those already diagnosed with the disease.

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“…These devices allow determination of corneal biomechanical parameters that may be associated with progression of glaucoma [60], although mechanistically associating parameter values with tissue structural features is challenging. These devices have also been used to elucidate relationships between corneal biomechanics and clinically relevant features such as retinal ganglion cell layer thickness [61 ▪▪ ], rates of visual field change [62], and incidence of optic disc hemorrhage (DH) [63]. These devices have also been used to identify differences in corneal biomechanics between healthy individuals and patients with several types of glaucoma, as well as the effects of filtering surgery (Table 1).…”

Section: Corneal Biomechanics In Glaucomamentioning

confidence: 99%

Glaucoma and biomechanics

Safa

Wong

et al. 2021

Current Opinion in Ophthalmology

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Purpose of reviewBiomechanics is an important aspect of the complex family of diseases known as the glaucomas. Here, we review recent studies of biomechanics in glaucoma. Recent findingsSeveral tissues have direct and/or indirect biomechanical roles in various forms of glaucoma, including the trabecular meshwork, cornea, peripapillary sclera, optic nerve head/sheath, and iris. Multiple mechanosensory mechanisms and signaling pathways continue to be identified in both the trabecular meshwork and optic nerve head. Further, the recent literature describes a variety of approaches for investigating the role of tissue biomechanics as a risk factor for glaucoma, including pathological stiffening of the trabecular meshwork, peripapillary scleral structural changes, and remodeling of the optic nerve head. Finally, there have been advances in incorporating biomechanical information in glaucoma prognoses, including corneal biomechanical parameters and iridial mechanical properties in angle-closure glaucoma.

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Relationship between optic disc hemorrhage and corneal hysteresis

Cited by 3 publications

References 49 publications

Corneal Biomechanical Measures for Glaucoma: A Clinical Approach

Corneal Biomechanical Measures for Glaucoma: A Clinical Approach

Corneal hysteresis: ready for prime time?

Glaucoma and biomechanics

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