Relationship Between Oral Health-Related Quality of Life and Salivary Cortisol Levels in Children With Caries

Khairani, Annisa; Fauziah, Eva; Budiardjo, Sarworini Bagio

doi:10.22159/ijap.2017.v9s2.31

Cited by 2 publications

(2 citation statements)

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“…Analysis of human saliva is a non-invasive and inexpensive test that can serve as a source of valuable information for diagnosis of several hormonal diseases including cushing's and nephrotic syndrome in adult and children [17,18]. The measurement of cortisol in saliva reflects the free and biologically active fraction of cortisol in plasma/serum.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Cortisol and Cortisone in Human Saliva by Uplc-MS/MS

Alvi

Hammami

2021

Int J Pharm Pharm Sci

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Objective: To develop and validate a simple and rapid assay for simultaneous measurement of cortisol and cortisone in human saliva by ultra-performance liquid chromatography-tandem mass spectrometry. Methods: Chromatographic analysis was performed on an Atlantis dC18 column (2.1 x 100 mm, 3 µm) using a mobile phase consisting of acetonitrile and 2 mmol ammonium-acetate (50:50, v; v) that was delivered at a flow rate of 0.3 ml/min. The eluents were monitored using electrospray ionization in the positive ion mode set at transition set of mass-to-charge (m/z): 363.11 → 121.00, 361.18 → 163.11, and 367.19 → 121.24 for cortisol, cortisone and internal standard (IS), respectively the method was validated for linearity, accuracy, precision, and recovery, according to international guidelines. Results: The retention times of cortisol, cortisone and internal were about 1.38, 1.43 and 1.38 min, respectively. Cortisol level and cortisone level relationship to the ratio of their respective peak-area to IS’s peak-area was linear (range of 0.5-100 ng/ml). Coefficients of variation and inaccuracy were, ≤9.9% and-0.3 to 6.9 for cortisol and ≤8.4 and-1.5 to 4.8 for cortisone, respectively. Extraction recoveries for cortisol, cortisone, and the IS were 90%, 94%, and 98%, respectively. Cortisol and cortisone stability was evaluated in processed saliva samples (stored at room temperature for 24 h) and unprocessed saliva samples (stored at room temperature for 24 h or at-20 °C for 10 w) and after 3 freeze-thaw cycles was ≥ 86%. Conclusion: The proposed method is simple, precise, and accurate for the rapid simultaneous measurement of cortisol and cortisone levels in saliva. The assay was successfully applied to determine levels of cortisol and cortisone in human saliva samples obtained from healthy volunteers.

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Section: Discussionmentioning

confidence: 99%

Measurement of Cortisol and Cortisone in Human Saliva by Uplc-MS/MS

Alvi

Hammami

2021

Int J Pharm Pharm Sci

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“…Children have a high risk of chronic infection in their teeth, caries is one of the possible infection (3),According to data from the Ministry of Health, the prevalence of caries in Indonesia is 88.8% with the highest age group being 5-9 years old (67.3%) ,in addition, based on Basic Health Research (RISKESDAS) 2018, the prevalence of cavities in children is still very high, which is approximately 93%, which means that only 7% of children in Indonesia are free of dental caries (4).…”

Section: Introductionmentioning

confidence: 99%

Nutritional Status and Caries at Children in Tajinan Sub-District Malang District

Seno Pradopo,

Sindy Cornelia Nelwan,

Franciska Prasetya Wijayanti

2023

World J. Adv. Res. Rev.

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Background: Caries is a multifactorial disease that can happen to all ages, caries and malnutrition are problems that often happens to children and can affect general health. Caries can be related to malnutrition. Caries can make the child uncomfortable and lower the child’s appetite, thus leading to the decrease of nutritional intake which can make the child’s tooth more susceptible to caries and make the existing caries more severe, then it’s back to the beginning where the worsened caries will make the child’s appetite worse and so on. Objectives: To know the relations between caries and nutritional status at children in Tajinan sub-district Malang district. Methods: 80 elementary students were selected from two elementary school at Tajinan sub-District Malang District. Then the nutritional status is measures by anthropometric, using the body mass index for age (IMT/U) and Z-score and the level of caries is measured by using DMF-T and def-t index. Conclusion: There is an inverse relationship between the two variables (nutritional status and caries) in children, which means the lower the child’s nutritional status the higher the caries is and vice versa. The Spearman significancy is p=0,012 (P<0,05). Conclusion: There is a relationship between nutritional status and caries.

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Relationship Between Oral Health-Related Quality of Life and Salivary Cortisol Levels in Children With Caries

Cited by 2 publications

References 6 publications

Measurement of Cortisol and Cortisone in Human Saliva by Uplc-MS/MS

Measurement of Cortisol and Cortisone in Human Saliva by Uplc-MS/MS

Nutritional Status and Caries at Children in Tajinan Sub-District Malang District

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