Relationship between overactive bladder and irritable bowel syndrome: a large‐scale internet survey in <scp>J</scp>apan using the overactive bladder symptom score and Rome <scp>III</scp> criteria

Matsumoto, Seiji; Hashizume, Kazumi; Wada, Naoki; Hori, J.; Tamaki, Gaku; Kita, Masafumi; Iwata, Tatsuya; Κakizaki, Hidehiro

doi:10.1111/j.1464-410x.2012.11591.x

Cited by 55 publications

(48 citation statements)

References 28 publications

(43 reference statements)

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“…In most Western countries, IBS affects more women (60%-70%) than men[42,43]. The prevalence of IBS in this study was 64.8% in females, which was similar to Western countries but higher than some Asian countries, such as India (59.69%)[44], and Japan(50%)[45]. Some previous studies in China had reported the prevalence of IBS in female patients as 56.50% in Shanghai[46], and 55.56% in Guangdong province[47].…”

Section: Discussionsupporting

confidence: 55%

Economic burden of irritable bowel syndrome in China

Zhang

Xiang

et al. 2016

WJG

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AIMTo estimate annual direct and indirect costs for patients diagnosed with irritable bowel syndrome (IBS) and subtypes.METHODSPatients completed a standardized questionnaire concerning usage of healthcare resources, travel costs, meals, and productivity loss of patients when seeking treatment for IBS. Total annual costs per patient were calculated as the sum of direct (including medical and nonmedical) and indirect costs. Total annual costs per patient among various IBS subtypes were compared. Analysis of variance and bootstrapped independent sample t-tests were performed to determine differences between groups after controlling for IBS subtypes.RESULTSA total of 105 IBS patients (64.80% female), mean age of 57.12 years ± 10.31 years), mean disease duration of 4.31 years ± 5.40 years, were included. Total annual costs per patient were estimated as CNY18262.84 (USD2933.08). Inpatient and outpatient healthcare use were major cost drivers, accounting for 46.41%and 23.36% of total annual costs, respectively. Productivity loss accounted for 25.32% of total annual costs. The proportions of direct and indirect costs were similar to published studies in other countries. Nationally, the total costs of managing IBS would amount to CNY123.83 billion (USD1.99 billion). Among the IBS subtypes, total annual costs per patient of IBS-M was highest at CNY18891.18 (USD3034). Furthermore, there was significant difference in productivity loss among IBS subtypes (P = 0.031).CONCLUSIONIBS imposes a huge economic burden on patients and healthcare systems, which could account for 3.3% of the total healthcare budget for the entire Chinese nation. More than two-thirds of total annual costs of IBS consist of inpatient and outpatient healthcare use. Among the subtypes, IBS-M patients appear to have the greatest economic burden but require further confirmation.

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Section: Discussionsupporting

confidence: 55%

Economic burden of irritable bowel syndrome in China

Zhang

Xiang

et al. 2016

WJG

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“…Higher OAB prevalence among women than men has been reported in Korea . In contrast, other Asian studies suggest a higher prevalence of OAB in men . Differences between study populations with regard to age may have contributed to these findings.…”

Section: Discussionmentioning

confidence: 71%

Prevalence of overactive bladder in China, Taiwan and South Korea: Results from a cross‐sectional, population‐based study

Chuang

Liu

Lee

et al. 2017

LUTS

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Objective: The aim of the present study was to determine the prevalence of overactive bladder (OAB) in individuals aged ≥40 years in China, Taiwan, and South Korea.Methods: The present cross-sectional population-representative Internet-based study investigated OAB symptoms in men and women aged ≥40 years using the overactive bladder symptom score. Additional instruments included the International Index of Erectile Function (men only) and the Sexual Quality of Life -Female (women only) questionnaires, as well as Patient Perception of Bladder Condition (PPBC).Results: In all, 8284 individuals participated in the study. The prevalence of OAB was 20.8% overall (women 22.1%, men 19.5%) and increased significantly with age, from 10.8% in those aged 40-44 years to 27.9% in those aged >60 years (P = .001). The presence of comorbid conditions (e.g. neurological disease, diabetes) was associated with a significantly increased prevalence of OAB.Increasing symptom severity was associated with significantly worsening patient perception of bladder condition responses. Just under half (48%) of those with no OAB had no lower urinary tract symptoms (LUTS), whereas 88% of those with severe symptoms had all 3 LUTS (International Continence Society definition) symptom categories (voiding, post-micturition, and storage symptoms). Of those without OAB, 10% reported visiting healthcare professionals for urinary symptoms, compared with 64% of those with severe OAB symptoms (P = .001). Increased symptom severity was significantly associated with lower sexual quality of life in both men and women.Conclusions: OAB symptoms were found to affect 1 in 5 individuals aged ≥40 years in China, Taiwan, and South Korea, becoming more common with increasing age. The results suggest that many more individuals with OAB could benefit by consulting healthcare professionals. K E Y W O R D SChina, overactive bladder, prevalence, Republic of Korea, Taiwan

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“…Various reports in the literature suggest the existence of overlap between OAB and some of the more commonly recognized central sensitization syndromes 36,41 , including IBS 77,92,94,120,121 , fibromyalgia 122–126 , and idiopathic back pain 127 . According to population data, over one-third of Japanese women with OAB have concomitant IBS, as defined by Rome criteria 128 , whereas American women are more likely to report a diagnosis of IBS if they have more severe storage-type lower urinary tract symptoms 120 . Women with IBS are also more likely to report storage-type lower urinary tract symptoms of greater severity than those without IBS 82 .…”

Section: Current Evidencementioning

confidence: 99%

Does central sensitization help explain idiopathic overactive bladder?

et al. 2016

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The pathophysiological mechanisms underlying overactive bladder syndrome (OAB) can include dysfunction of sensory pathways of the peripheral and central nervous systems, resulting in bladder hypersensitivity. Central sensitization describes an induced state of spinal hypersensitivity that is associated with a variety of chronic pain disorders that share many attributes with OAB, albeit without the presence of pain. As such, the concept of central sensitization might be relevant to understanding the mechanisms and clinical manifestations of OAB syndrome. An understanding of the pathophysiology and clinical manifestations of central sensitization, and the evidence that supports a role of central sensitization in OAB, including the potential implications of mechanisms of central sensitization for the treatment of patients with OAB could provide a novel approach to the treatment of patients with this disease. Such an approach would be especially relevant to those patients with central sensitization-related comorbidities, and has the potential to improve the outcomes of these patients in particular.

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Relationship between overactive bladder and irritable bowel syndrome: a large‐scale internet survey in Japan using the overactive bladder symptom score and Rome III criteria

Cited by 55 publications

References 28 publications

Economic burden of irritable bowel syndrome in China

Economic burden of irritable bowel syndrome in China

Prevalence of overactive bladder in China, Taiwan and South Korea: Results from a cross‐sectional, population‐based study

Does central sensitization help explain idiopathic overactive bladder?

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