Relationship between oxidative stress and muscle mass loss in early postmenopause: An exploratory study

Zacarías-Flores, Mariano; Sánchez-Rodrı́guez, Martha A.; García-Anaya, Oswaldo Daniel; Correa-Muñoz, Elsa; Mendoza-Núñez, Vı́ctor Manuel

doi:10.1016/j.endien.2018.01.006

Cited by 14 publications

(12 citation statements)

References 27 publications

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“…A previous large cross-sectional study including 3,079 participants reported that SUA was positively associated with ASMI in middle-aged and older "healthy" people using dual-energy X-ray absorptiometry [15]. Another study revealed a positive correlation between SUA and skeletal muscle index in postmenopausal women from Mexico [23]. The different sex-specific associations in PD patients revealed in our study may be explained by the following mechanism.…”

Section: Discussionsupporting

confidence: 40%

The Association between Serum Uric Acid and Appendicular Skeletal Muscle Mass and the Effect of Their Interaction on Mortality in Patients on Peritoneal Dialysis

Xiao

Chen

Peng

et al. 2020

Kidney Blood Press Res

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Background: Serum uric acid (SUA) has been revealed to be positively associated with the body composition parameters in hemodialysis patients, but few studies have investigated that in patients on peritoneal dialysis (PD). The aim of this study was to identify the relationship between SUA and appendicular skeletal muscle mass (ASM) and the effect of their interaction on mortality in PD patients. Methods: This was a single-center retrospective cohort study. Patients who underwent multifrequency bioelectrical impedance analysis between January 1, 2013, and December 31, 2016, and had data on SUA values were enrolled. All patients were followed up until December 31, 2019. Results: In total, 802 prevalent PD patients (57.9% male), with mean age of 46.2 ± 14.2 years were enrolled. The average SUA and ASM were 6.8 ± 1.3 mg/dL and 21.2 ± 4.9 kg. According to multiple linear regression models, SUA was positively associated with relative ASM in middle-aged and older PD patients (standardized coefficients [β] 0.117; 95% confidence interval [CI] 0.027, 0.200; p = 0.010). Further sex-stratified analysis showed that the association existed only in males (β 0.161; 95% CI 0.017, 0.227; p = 0.023). Moreover, the presence of hyperuricemia was found to predict lower risk of all-cause mortality (hazard ratio [HR] 0.514, 95% CI 0.272, 0.970; p = 0.040) only in patients with lower relative ASM. And, the adjusted HR of every 1 mg/dL elevated SUA level was 0.770 (95% CI 0.609, 0.972; p = 0.028) for all-cause mortality in the lower relative ASM subgroup. Conclusions: There exists a positive association between the SUA and ASM, and the ASM significantly affected the association between SUA and all-cause PD mortality.

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Section: Discussionsupporting

confidence: 40%

The Association between Serum Uric Acid and Appendicular Skeletal Muscle Mass and the Effect of Their Interaction on Mortality in Patients on Peritoneal Dialysis

Xiao

Chen

Peng

et al. 2020

Kidney Blood Press Res

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“…A recent study showed that the loss of muscle mass in menopause, due to declining estrogen levels, was negatively associated with oxidative stress (LPO), but skeletal muscle mass was positively Fig. 1 Predicted probability of symptoms occurring at given levels of SMI (adjusted for FFMI and FMI) in women with no VMS at visit 6 (baseline) associated with serum uric acid which offers a protective role against oxidative stress due to its capacity to clear reactive oxygen species [40]. Increased oxidative stress has been found to also impair the ability of free oxygen radical defenses (FORD) in menopausal women, and that VMS are negatively associated with FORD [41].…”

Section: Discussionmentioning

confidence: 99%

Association of lean body mass to menopausal symptoms: The Study of Women's Health Across the Nation

Woods

Hess

Biddington

et al. 2020

womens midlife health

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Background The purpose of this study was to examine the association of lean body mass (LBM) to the development of vasomotor symptoms (VMS) as women transition through menopause. Methods This study is a secondary use of data available for public use from follow up visits six through 10 for participants in the Study of Women’s Health Across the Nation. The study examined 2533 women, between the ages 42–52 years, each year over a10-year period. Data was modeled for associations of lean body mass and VMS. Changes in LBM since prior visit and since baseline were also modeled along with differences in means using binary logistic regression, adjusting for covariates. Results LBM was significantly associated to concurrent VMS (p = .036), percent change in LBM since prior visit (p = .003), percent change since baseline (p < .001), and overall means associations (p = .023). LBM was not significant for VMS at individual visit measures. In mixed regression modeling, time was significant (p < .0001) at all visits. The estimated probability of developing VMS decreases significantly as LBM increases. Conclusions Lean body mass is negatively associated with incident VMS. Our data suggests that maintaining higher levels of LBM during the menopausal transition may be protective against the development of VMS. Every woman will experience menopause in her life and the ability to potentially prevent the onset of specific symptoms through basic interventions, such as resistance training to increase lean body mass, may positively impact this large population.

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“…Lipoperoxide (LPO) levels are considered a measure of oxidative stress and in postmenopausal women are found to be significantly higher than in premenopausal women suggesting that the depletion of estrogen is a risk factor for oxidative stress 32 . A recent study showed that the loss of muscle mass in menopause, due to declining estrogen levels, was negatively associated with oxidative stress (LPO), but skeletal muscle mass was positively associated with serum uric acid which offers a protective role against oxidative stress due to its capacity to clear reactive oxygen species 33 .…”

Section: Discussionmentioning

confidence: 99%

Association of Lean Body Mass to Menopausal Symptoms: The Study of Women’s Health Across the Nation

Woods

Hess

Biddington

et al. 2020

Preprint

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Background The purpose of this study was to examine the association of lean body mass (LBM) to the development of vasomotor symptoms (VMS) as women transition through menopause. Methods This study is a secondary use of data available for public use from follow up visits six through 10 for participants in the Study of Women’s Health Across the Nation. The study examined 2,533 women, between the ages 42 – 52 years, each year over a10-year period. Data was modeled for associations of lean body mass and VMS. Changes in LBM since prior visit and since baseline were also modeled along with differences in means using binary logistic regression, adjusting for covariates. Results LBM was significantly associated to concurrent VMS ( p = .036), percent change in LBM since prior visit ( p = .003), percent change since baseline ( p <.001), and overall means associations ( p = .023). LBM was not significant for VMS at individual visit measures. In mixed regression modeling, time was significant ( p <.0001) at all visits. The estimated probability of developing VMS decreases significantly as LBM increases. Conclusions Lean body mass is negatively associated with incident VMS. Our data suggests that maintaining higher levels of LBM during the menopausal transition may be protective against the development of VMS. Every woman will experience menopause in her life and the ability to potentially prevent the onset of specific symptoms through basic interventions, such as resistance training to increase lean body mass, may positively impact this large population.

show abstract

Relationship between oxidative stress and muscle mass loss in early postmenopause: An exploratory study

Cited by 14 publications

References 27 publications

The Association between Serum Uric Acid and Appendicular Skeletal Muscle Mass and the Effect of Their Interaction on Mortality in Patients on Peritoneal Dialysis

The Association between Serum Uric Acid and Appendicular Skeletal Muscle Mass and the Effect of Their Interaction on Mortality in Patients on Peritoneal Dialysis

Association of lean body mass to menopausal symptoms: The Study of Women's Health Across the Nation

Association of Lean Body Mass to Menopausal Symptoms: The Study of Women’s Health Across the Nation

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