Relationship between Oxidative Stress, Physical Activity, and Vitamin Intake in Patients with Asthma

Abstract

Background Oxidative stress plays an important role in the pathogenesis of bronchial asthma. Antioxidant nutrition and supplementation have been used to reduce oxidative stress. However, a clinical trial with antioxidant supplementation showed no beneficial effects in patients with asthma. On the other hand, physical activity is related to the prognosis of chronic obstructive pulmonary disease (COPD) and is also related to oxidant status. We investigated the relationships between oxidative stress, serum levels of vitamins, dietary vitamin intake, daily activities, and pulmonary functions in patients with asthma. Methods Eighteen patients with bronchial asthma were enrolled in this study. Reactive oxidative stress was assessed by measuring organic hydroperoxides (diacron reactive oxygen metabolites: dROM) in sera and by measuring H 2 O 2 levels in exhaled breath condensates. The biological antioxidant capacity in serum was evaluated by measuring antioxidant potential capacity against ferric ion. We also assessed pulmonary functions, fraction of exhaled nitric oxide, serum levels of vitamins, dietary vitamin intake, and physical activities. Results There were no relationships between the index of oxidative stress (dROM and H 2 O 2 in exhaled breathe condensates) and pulmonary functions, serum levels of vitamins, daily vitamin intakes, and activity levels in patients with asthma. Conclusion The status of transient oxidative stress may not be related to daily activities, vitamin levels, and pulmonary functions in patients with asthma in a real-life setting. However, our results were obtained in the short-term period from a small number of subjects, so a large longitudinal study is required to ascertain the relationships between oxidative stress, physical activity and vitamin intake in patients with asthma.

Key Considerations When Addressing Physical Inactivity and Sedentary Behaviour in People with Asthma

“…A total of 17 studies explored correlates (k = 13) [ 19 , 39 , 40 , 42 , 43 , 44 , 45 , 46 , 47 , 49 , 51 , 52 , 53 ] or determinants (k = 6) [ 22 , 41 , 43 , 46 , 47 , 48 , 50 ] of physical activity or sedentary behaviour; most (82%) were of cross-sectional design ( Table 2 ). Of the 17 studies, 10 (59%) assessed physical activity or sedentary behaviour with pedometers or accelerometer devices ( Table 2 ).…”

“…Only one of four studies found a statistically significant correlation between physical activity and QoL [ 53 ]. Studies that assessed the correlation between physical activity and eosinophils [ 22 , 48 , 51 , 53 ], Immunoglobulin E (IgE) [ 51 ], and markers of oxidative stress [ 45 ] did not find statistically significant results. However, associations with physical activity were found for high-sensitivity C-reactive protein (r 2 = 0.15) [ 22 , 48 ] and fractional concentration of exhaled nitric oxide (FeNo) (r = −0.37, p = 0.005) [ 53 ].…”

“…PRISMA flowchart.3.2.2. Aim 2: Correlates and Determinants of Physical Activity and Sedentary BehaviourA total of 17 studies explored correlates (k = 13)[19,39,40,[42][43][44][45][46][47]49,[51][52][53] or determinants (k = 6)[22,41,43,[46][47][48]50] of physical activity or sedentary behaviour; most (82%) were of cross-sectional design (Table2). Of the 17 studies, 10 (59%) assessed physical activity or sedentary behaviour with pedometers or accelerometer devices (Table2).…”

The Association between Vigorous Physical Activity and Stress in Adolescents with Asthma

“…Vigorous PA is particularly more effective in strengthening cardiorespiratory fitness [ 22 ] compared with moderate activity; however, no study has confirmed its effect by evaluating vigorous PA in adolescents. Additionally, in this field, large-scale research is necessary for proactive healthcare for adolescents [ 23 ]. Thus, this study analyzed the association between vigorous PA and stress in adolescents with asthma using the data from a large-scale survey of Korean adolescents.…”

Study of vitamins, antioxidant and trace elements on various spirometric parameters and quality of life in patients of bronchial asthma

“…Zn has beneficial roles in respiratory epithelium: as an antioxidant, anti-inflammatory agent, antiapoptotic agent, cofactor for DNA synthesis .Se has a crucial role in the inflammatory asthmatic process with the ability to affect the adhesion molecules expression. 7 Severity of airflow limitation, its reversibility, variability and confirmation of asthma can be assessed by measurement of lung function. Spirometry (FEV 1 %) is the most commonly and widespread acceptance methods to assess airflow limitation.…”