Relationship between oxidized low-density lipoprotein antibodies and obesity in different glycemic situations

Abstract

BackgroundAutoantibodies to oxidized low-density lipoprotein (oxLDL) are a heterogeneous group of antibodies that are controversially discussed to be either pathogenic or protective. Biochemical and anthropometric measurements correlated with increased levels of these antibodies are also controversial, especially in conditions of impaired glucose tolerance and type 2 diabetes mellitus. The present study was conducted to evaluate levels of oxLDL antibodies and their correlation with obesity in different glycemic situations.MethodsTwo hundred and seventy-four adult males were classified into three subgroups: group 1 (n=125), comprising a control group of nondiabetic subjects; group 2 (n=77), comprising subjects with impaired glucose tolerance; and group 3 (n=72), comprising patients with type 2 diabetes mellitus. Body mass index was calculated, and measurement of oxLDL and oxLDL antibodies was performed.ResultsHigher mean concentrations of oxLDL were found in the type 2 diabetes mellitus and impaired glucose tolerance groups (143.5±21.9 U/L and 108.7±23.7 U/L, respectively). The mean value for the control group was 73.5±27.5 U/L (P<0.001). Higher mean concentrations of anti-oxLDL antibodies were observed in the type 2 diabetes mellitus and impaired glucose tolerance groups (55.7±17.8 U/L and 40.4±17.6 U/L, respectively). The mean value for the control group was 20.4±10 U/L (P<0.001). Levels of anti-oxLDL antibodies were found to be positively and significantly correlated with body mass index in the control group (r=0.46), impaired glucose tolerance (r=0.51), type 2 diabetes mellitus group (r=0.46), and in the whole study population (r=0.44; P<0.001).ConclusionAnti-oxLDL antibody levels were increased in subjects with type 2 diabetes mellitus and impaired glucose tolerance and were positively correlated with obesity and body mass index.

Autoantibodies to post‐translationally modified type I and II collagen in Charcot neuroarthropathy in subjects with type 2 diabetes mellitus

“…More recently, the presence of antibodies against autonomous nerve structures in participants with type 1 diabetes mellitus has also been reported . People with impaired glucose tolerance and T2DM demonstrated higher levels of antibodies against oxidized low‐density lipoproteins, which predict cardiovascular events as myocardial infarction …”

“…15 People with impaired glucose tolerance and T2DM demonstrated higher levels of antibodies against oxidized low-density lipoproteins, which predict cardiovascular events as myocardial infarction. 16 However, no study has focused on the possible presence of autoimmunity in CN. To test this hypothesis, we exposed in vitro proteins to ROS (such as ribose, OH, HOCl, and ONOO) known to be present in the inflamed tissues.…”

Oxidized LDL and NO synthesis—Biomarkers of endothelial dysfunction and ageing

“…Recently, the association between dyslipidemia and oxidation of LDL has been demonstrated in elderly individuals, even in the pre-diabetic state (Gradinaru et al, 2013). In this regard, an increase in immunologically detected epitopes of oxLDL in subjects with abdominal obesity was reported by several authors (Couillard et al, 2005;Weinbrenner et al, 2006;Njajou et al, 2009;Babakr et al, 2014). Thus, higher levels of oxLDL were associated with increased incidence of metabolic syndrome (MetS) overall, as well as its components of abdominal obesity, hyperglycemia and hypertriglyceridemia in the population-based, prospective, observational study CARDIA (The Coronary Artery Risk Development in Young Adults) (Holvoet et al, 2008a,b).…”

Changes in Oxidized Low-Density Lipoprotein Rather Than in Paraoxonase1 are Associated with Changes in the Leptin/Leptin Receptor Ratio in Obese Children During Weight-Loss Therapy

“…Moreover, higher ox-LDL concentrations have been associated with higher body mass index (BMI), body fat, leptin levels and insulin resistance [13,15]. Studies concerning autoantibodies to oxidized LDL (anti ox-LDL) were conducted mostly in adults in relation to the progression of atherosclerosis and type 2 diabetes [16,17]. The protective or pathogenic role of the immune response to ox-LDL has not yet been established.…”