Relationship between PABA and Lundh tests: lack of influence of duodenal pH in vivo

Kay, G; Tetlow, Vincent A.; Braganza, Joan M.

doi:10.1016/0009-8981(83)90061-x

Cited by 14 publications

(7 citation statements)

References 12 publications

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“…In addition, two separate urine collections are required, in creasing the likelihood of error and patient non-compliance. A very close correlation be tween PEI result and Lundh result has been demonstrated and this corresponds closely to the results from another centre [5]. We con clude, like them, that the Lundh and NBT-PABA/I4C-PABA are 'equally discriminat ing methods of assessing pancreatic exocrine function'.…”

Section: Discussionsupporting

confidence: 88%

“…The results are expressed as a proportion of total oral dose excreted in the urine within 6 h and the PEI (PABA excretion index) indicates the ratio of 6-hour urinary chemical recovery of PABA to 6-hour urinary radio isotope recovery of PABA. It should be noted that substantially less radioactivity has been administered in this study compared with previous published re ports [5,7], All chemical analyses were performed in duplicate and blanks used on each specimen.…”

Section: Nb T-paba/i4c-pa Bamentioning

confidence: 99%

“…Consequently, the single day NBT-PABA/14C-PABA has been developed [7], which includes a tracer dose of PABA as a marker of PABA absorption. This test has been shown to be highly dis criminatory in distinguishing pancreatic dis ease from other gastrointestinal disease and from normal subjects [5,7]. Only a small number of reports have been published on experience with this test [5,7] and we wish to indicate our experience and to highlight the simplicity of the test and the reliability of the results.…”

mentioning

confidence: 94%

“…Kay el al. [5] have indicated that separate day collections for urinary recoveries of /7-aminobenzoic acid demonstrate poor reproducibil ity and this is likely to be true for fluorescein recoveries with the 2-day pancreolauryl test. The single day NBT-PABA (N-benzoyl-Ltyrosyl-p-aminobenzoic acid) test requires only a 6-hour urine collection but may be unreliable in subjects with other gastrointes tinal abnormalities [6].…”

mentioning

confidence: 99%

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An Evaluation of the One-Day NBT-PABA/<sup>14</sup>C-PABA in the Assessment of Pancreatic Exocrine Insufficiency

et al. 1984

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The one-day NBT-PABA/¹⁴C-PABA has been performed on 58 consecutive subjects with suspected or established pancreatic disease. 23 of these were normal subjects, 12 were subsequently shown to have other gastrointestinal disease and 23 had proven pancreatic disease. A PABA excretion index (PEI) has been calculated and, using our lower limit of normality (0.61), the test has shown an overall sensitivity of 83 % and specificity of 89 %. False positives were a particular problem in the other gastrointestinal disease group (25%). There was a close correlation between PEI and Lundh mean tryptic activity (r = 0.89). These results indicate that this test is a satisfactory screening test for pancreatic exocrine disease and is easier to perform with less likelihood of error than many other non-invasive tests of pancreatic function.

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Section: Discussionsupporting

confidence: 88%

Section: Nb T-paba/i4c-pa Bamentioning

confidence: 99%

mentioning

confidence: 94%

mentioning

confidence: 99%

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An Evaluation of the One-Day NBT-PABA/<sup>14</sup>C-PABA in the Assessment of Pancreatic Exocrine Insufficiency

et al. 1984

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“…One of the indirect tests used routinely in clinical practice is the PABA or bentiromide test. The test involves the cleavage of PABA by chymotrypsin in the duodenum 10 . The split product of PABA is absorbed in the small bowel, metabolized in the liver and excreted by the kidneys, and is a measure of exocrine pancreatic insufficiency.…”

Section: Introductionmentioning

confidence: 99%

A prospective, comparative study of the para‐aminobenzoic acid test and faecal elastase 1 in the assessment of exocrine pancreatic function

Sonwalkar

Holbrook

Phillips

et al. 2003

Aliment Pharmacol Ther

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SUMMARYBackground: The assessment of exocrine pancreatic insufficiency is part of the routine work-up of patients with persistent diarrhoea or suspected steatorrhoea. Direct and indirect tests for the diagnosis of exocrine pancreatic insufficiency have their drawbacks. Measurement of faecal elastase 1 by enzyme-linked immunoabsorbent assay is a simple, non-invasive, robust test for exocrine pancreatic insufficiency. Methods: We performed a prospective comparison of the para-aminobenzoic acid test and faecal elastase 1 test in 45 patients being investigated for diarrhoea or suspected steatorrhoea. Details of clinical suspicion, imaging and response to treatment were recorded. Results: Exocrine pancreatic function was normal in 20 patients with normal para-aminobenzoic acid and faecal elastase 1 levels. Eight patients had exocrine pancreatic

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The Bentiromide Test for Pancreatic Exocrine Insufficiency

Toskes

1984

Pharmacotherapy

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The bentiromide test, a test of pancreatic exocrine function, has recently been approved for clinical use by the Food and Drug Administration. The test has been studied in adult patients with chronic pancreatic disease and in children with cystic fibrosis. The 500-mg dose and 6-hour urine collection period appear optimal for separating patients with chronic pancreatic disease from control subjects. Side effects with the 500-mg dose are virtually nonexistent. This simply performed outpatient test of chymotrypsin function appears to be an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency.

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Relationship between PABA and Lundh tests: lack of influence of duodenal pH in vivo

Cited by 14 publications

References 12 publications

An Evaluation of the One-Day NBT-PABA/<sup>14</sup>C-PABA in the Assessment of Pancreatic Exocrine Insufficiency

An Evaluation of the One-Day NBT-PABA/<sup>14</sup>C-PABA in the Assessment of Pancreatic Exocrine Insufficiency

A prospective, comparative study of the para‐aminobenzoic acid test and faecal elastase 1 in the assessment of exocrine pancreatic function

The Bentiromide Test for Pancreatic Exocrine Insufficiency

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