Relationship between periodontal disease and osteoporosis

Megson, Emma; Kapellas, Kostas; Bartold, P. Mark

doi:10.1111/j.1744-1609.2010.00171.x

Cited by 28 publications

(20 citation statements)

References 105 publications

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“…Systemic hormones and inflammatory cytokines play key role in osteoclast formation and activation 38, 43, 46, 47 . Indeed, association of systemic diseases that show increased osteoclast activity with periodontal bone loss has been explored 48, 49, 51 . Our results suggest a bone-site specific regulation of osteoclast activation.…”

Section: Discussionmentioning

confidence: 99%

Diverse Osteoclastogenesis of Bone Marrow From Mandible Versus Long Bone

Chaichanasakul

Kang

Bezouglaia

et al. 2014

Journal of Periodontology

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Background Mandible (MB) and maxilla possess unique metabolic and functional properties and demonstrate discrete responses to homeostatic, mechanical, hormonal and developmental stimuli. Osteogenic potential of bone marrow stromal cells (BMSCs) differs between MB versus long bones (LB). Furthermore, MB versus LB derived osteoclasts (OCs) have disparate functional properties. Here, we explored the osteoclastogenic potential of rat MB versus LB marrow in vitro and in vivo under basal and stimulated conditions. Methods Bone marrow from rat MB and LB was cultured in osteoblastic or osteoclastic differentiation media. Tartrate resistant acid phosphatase (TRAP) staining, resorption pit assays, and real-time PCR were performed. Additionally, osmotic mini-pumps were implanted in animals, mandibles and tibiae were isolated and multinucleated cells (MNCs) were measured. Results MB versus LB marrow cultures differentiated with RANKL and M-CSF produced more TRAP+ multinucleated cells (MNCs) and greater resorptive area. To explore MB versus LB BMSC supported osteoclastogenesis, confluent BMSCs were cultured with parathyroid hormone (PTH), 1α,25-dihydroxyvitaminD3 (1,25D3), or PTH+1,25D3. 1,25D3 or PTH+1,25D3 treated LB BMSCs expressed significantly higher RANKL and lower OPG mRNA and increased RANKL:OPG ratio. When whole marrow was cultured with PTH+1,25D3, more TRAP+ MNCs were seen in LB versus MB cultures. Ultimately, rats were infused with PTH+1,25D3 and MB versus tibia MNCs were measured. Hormonal stimulation increased osteoclastogenesis in both MB and tibia. However, higher TRAP+ MNC numbers were observed in tibia versus MB under basal and hormonal stimulation. Conclusions Collectively, our data illustrate differences both on osteoclastogenic potential and OC numbers of MB versus LB marrow.

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Section: Discussionmentioning

confidence: 99%

Diverse Osteoclastogenesis of Bone Marrow From Mandible Versus Long Bone

Chaichanasakul

Kang

Bezouglaia

et al. 2014

Journal of Periodontology

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“…It is usually caused by microorganisms that get adherent to tooth surface and grow in its vicinity with aggressive immune response against these and thus causing swelling, redness, congestion, and pain in tissues surrounding the teeth. 1 Many researches have defined a probable role for periodontal disease as a risk factor for systemic diseases, 2 consists of diabetes, 3 osteoporosis, 4 cardiovascular diseases, 5 adverse pregnancy outcome, 6 rheumatoid arthritis, 7 and respiratory disease such as chronic obstructive pulmonary disease (COPD). 8,9 The chronic obstructive pulmonary disease is an inflammatory condition with progressive deterioration of pulmonary function and increasing airway obstruction 10,11 consists of emphysema and chronic bronchitis.…”

Section: Introductionmentioning

confidence: 99%

The Associations between Periodontitis and Respiratory Disease

Moghadam

Shirzaiy

Risbaf

2017

J Nepal Health Res Council

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Researches have shown positive correlation between periodontitis and respiratory diseases such as chronic obstructive pulmonary disease. We reviewed the literature to assess the relationship between periodontitis and respiratory diseases. This study involved a review of relevant English literature published regarding periodontitis and respiratory diseases during the period of 1994-2015. The analysis of literature related to the topic showed there is association between periodontitis and respiratory diseases such as chronic obstructive pulmonary disease and pneumonia. It was found that periodontitis is associated with respiratory diseases due to poor oral hygiene and low immunity state.

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“…At least approximately 35% dentate adults aged between 30 and 90 years old in the United States experience PD [1], and this disease can affect up to 90% of the global population [2]. Based on the theory of “focal infection” which emerged at the beginning of the twentieth century, many studies have investigated a possible role for PD as a risk factor for systemic conditions over the past two decades [3], including cardiovascular diseases [4], diabetes [5], adverse pregnancy outcome [6], osteoporosis [7], rheumatoid arthritis [8], and Chronic obstructive pulmonary disease (COPD) [9], [10].…”

Section: Introductionmentioning

confidence: 99%

Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Observational Studies

et al. 2012

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BackgroundMany epidemiological studies have found a positive association between periodontal disease (PD) and risk of chronic obstructive pulmonary disease (COPD), but this association is varied and even contradictory among studies. We performed a meta-analysis to ascertain the relationship between PD and COPD.MethodsPubMed and Embase database were searched up to January 10, 2012, for relevant observational studies on the association between PD and risk of COPD. Data from the studies selected were extracted and analyzed independently by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis software.ResultsFourteen observational studies (one nested case-control, eight case-control, and five cross-sectional) involving 3,988 COPD patients were yielded. Based on random-effects meta-analysis, a significant association between PD and COPD was identified (odds ratio = 2.08, 95% confidence interval = 1.48–2.91; P<0.001), with sensitivity analysis showing that the result was robust. Subgroups analyses according to study design, ethnicity, assessment of PD/COPD, and adjusted/unadjusted odds ratios also revealed a significant association. Publication bias was detected.ConclusionsBased on current evidence, PD is a significant and independent risk factor of COPD. However, whether a causal relationships exists remains unclear. Morever, we suggest performing randomized controlled trails to explore whether periodontal interventions are beneficial in regulating COPD pathogenesis and progression.

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Relationship between periodontal disease and osteoporosis

Abstract: More prospective studies are required to determine what, if any, relationships exist between periodontal disease and reduced bone mineral density.

Cited by 28 publications

References 105 publications

Diverse Osteoclastogenesis of Bone Marrow From Mandible Versus Long Bone

Diverse Osteoclastogenesis of Bone Marrow From Mandible Versus Long Bone

The Associations between Periodontitis and Respiratory Disease

Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Observational Studies

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