Relationship between periodontitis and cardiovascular diseases: A literature review

Kızıldağ, Alper

doi:10.5321/wjs.v3.i1.1

Cited by 3 publications

(2 citation statements)

References 112 publications

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“…8 On the other hand, different inflammatory factors released during periodontal inflammation 7 can reach blood and promote systemic and arterial inflammation complicating the early atherosclerotic processes and advancing the atherosclerotic plaque development and the risk for plaque instability 9 which can lead to atherothrombotic cardiovascular events such as myocardial infarction. 10 Indirectly, pro-inflammatory cytokines and chemokines also could cause oxidative stress by recruiting polymorphonuclear leukocytes, 7 that produce reactive oxygen species (ROS), 11,12 and increasing mitochondrial production of ROS. 13 Actually, overwhelming evidence indicates that oxidative stress plays a central role in the periodontal tissue and alveolar bone destruction.…”

Section: Introductionmentioning

confidence: 99%

Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis

Díaz

Bullón

Ruíz-Salmerón

et al. 2020

J of Periodontal Research

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Background and Objective: Our aims were to improve the understanding of the pathogenic relationship between cardiovascular diseases and periodontitis and to generate new perspectives in the prevention and treatment of acute myocardial infarction (AMI) and periodontitis. The present study evaluates possible differences in inflammation, oxidative stress, and autophagy markers among subject suffering AMI, periodontitis, or both, to explore possible common pathogenic mechanisms. Material and Methods:A total of 260 subjects were enrolled in the study: 106 subjects that survived to a first AMI (AMI group) and 154 subjects had no cardiac events in their clinical record (control group). A questionnaire was used to assess age, height, weight, blood pressure, and heart rate. The clinical probing depth, clinical attachment loss, number of remaining teeth, and average number of sites with bleeding on probing were assessed. Lipid peroxidation and protein levels of phosphorylated AMPactivated protein kinase (p-AMPK) and microtubule-associated proteins 1A/1B-light chain 3-II (LC3-II) were determined in isolated peripheral blood mononuclear cells by thiobarbituric acid reactive substances (TBARS) assay and Western blot, respectively. Plasma levels of interleukin-1β were determined using a commercial ELISA kit.All the obtained variables were compared between subjects suffering an AMI with or without periodontitis and control subject periodontal healthy or with periodontitis.Results: A higher proportion of subjects suffering AMI + periodontitis than only AMI (without periodontitis) was found. Higher levels of TBARS were found in subjects with periodontitis than in subjects without periodontitis in both AMI and control subjects. Positive correlations between IL-1β levels and TBARS and between IL-1β levels and LC3-II were found only in control subjects. Conclusion:Results from the present study are consistent with the suggestion of periodontitis as a potential risk factor for AMI. Periodontitis association with circulating lipid peroxides in both AMI and control subjects were found. The absence of differences in IL-1β levels between AMI subjects (only AMI vs AMI + periodontitis)

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Section: Introductionmentioning

confidence: 99%

Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis

Díaz

Bullón

Ruíz-Salmerón

et al. 2020

J of Periodontal Research

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“…When tooth cleaning is not adequate, plaque can accumulate, which increases the risk for caries [5], gingivitis [6], and periodontal diseases [7]. Periodontal disease is associated with increased risk for cardiovascular diseases [8,9], type 2 diabetes [10], preterm birth [11], low birth weight [12] and low sperm count [13]. The risk of endstage renal disease and cardio-renal mortality increases in people with periodontitis and type-2 diabetes [10].…”

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confidence: 99%

Association Between Water, Sanitation, General Hygiene And Oral Hygiene Practices Of Street-Involved Young People In Southwest Nigeria

Foláyan

Obiyan

Olaleye

2019

Preprint

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Background Oral hygiene practices can be linked to personal hygiene practices, including access to water and other sanitation facilities. The objective of the study was to determine if there is an association between oral hygiene practices and water and sanitation hygiene (WASH) practices among street-involved young people (SIYP).Methods A cross-sectional study involving SIYP age 10-24 years in two states in Nigeria recruited through respondent-driven sampling was conducted. Interviewer-administered questionnaires were used to collect data on water access, sanitation personal and oral hygiene. The instruments used for collecting the data were standardized tools for measuring the phenomena studied. The association between knowledge and practice of oral hygiene; oral hygiene and water, sanitation and hygiene (WASH), and indicators of good oral hygiene were assessed.Results We found that the proportion of SIYP with good knowledge of oral hygiene was high (84.9%), but fewer had good oral hygiene practice (8.9%). There were significant associations between knowledge and practice of tooth cleaning, use of fluoride-containing toothpaste, dental flossing, consumption of sugar between meals, and frequency of dental check-ups (p<0.001 respectively). Respondents with good water collection and storage (AOR: 2.40; 95% CI: 1.31-4.38; P=0.004) and those residing in Lagos (AOR: 2.61; 95% CI: 1.42-4.80; P=0.002) had higher likelihood of having good oral hygiene.Conclusion Good oral hygiene practices of SIYP in Nigeria is associated with access to water collection and storage. WASH programs can have impact on health through improved oral hygiene practices.

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Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease

et al. 2021

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Relationship between periodontitis and cardiovascular diseases: A literature review

Cited by 3 publications

References 112 publications

Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis

Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis

Association Between Water, Sanitation, General Hygiene And Oral Hygiene Practices Of Street-Involved Young People In Southwest Nigeria

Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease

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