Relationship between physical activity practice and metabolic profile of postmenopausal women under treatment with aromatase inhibitors for breast cancer

Paulo, Thaís Reis Silva de; Viezel, Juliana; Aro, Bruna Lopes de; Seidinger, Sylvia Chedid; Trindade, Ana Carolina; Christófaro, Diego Giulliano Destro; Freitas, Ismael Forte

doi:10.1016/j.ejogrb.2017.07.003

Cited by 2 publications

(3 citation statements)

References 32 publications

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“…Studies investigating differences in the use of AI vs. tamoxifen have shown a higher risk of cardiovascular events in users of AI 23,24 . The use of AI may cause a decrease in the practice of PA for older women with BC 25 , and it is known that its use can lead to musculoskeletal symptoms 26 , osteoporosis and bone fractures 27 . Given the above, it is important that older women who receive AI are prescribed tailored exercises within the oncology setting.…”

Section: Discussionmentioning

confidence: 99%

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Factors Associated with Cardiorespiratory Fitness in Breast Cancer Survivors from the State of Santa Catarina, Brazil: Cross-Sectional Study

Boing

Raimundo

Pereira

et al. 2023

Rev. Bras. Cancerol.

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Introduction: Oxygen consumption (VO2) is indicative of cardiorespiratory fitness (CRF) and lower levels are related to a higher risk of total mortality among individuals with cancer whose therapy can have adverse consequences on the cardiovascular system. Objective: To examine the associations of patient-reported sociodemographic, clinical, anthropometric outcomes and functional variables with CRF in 69 women (55±10 years) and to identify whether walking is a predictor of peak VO2 variation in this population with breast cancer (BC). Method: Female BC survivors receiving hormone therapy after two types of surgery (breast-conserving and mastectomy) underwent a CRF test on a cycle ergometer to measure peak VO2. A questionnaire containing sociodemographic, clinical data, patient reported outcomes (PROs) (depressive symptoms, sleep quality, fatigue, body image) and self-reported walking and tests to measure body fat percentage, waist circumference, flexibility and shoulder range of motion (RoM) were performed. Results: Unemployment and retirement were associated with low CRF, as was the use of aromatase inhibitors instead of tamoxifen. Depressive symptoms, worse body image, greater waist circumference, less flexibility and shoulder RoM were also associated with low CRF. Walking duration, controlled for age and body mass index (BMI), is a 13% predictor of peak VO2 variance in this sample. Conclusion: These factors must be considered in understanding the CRF profile of BC survivors. As walking was a predictor of peak VO2 variance, it should be recommended as a type of physical activity for patients with BC using hormone therapy.

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Section: Discussionmentioning

confidence: 99%

“…According to the literature [10][11][12] age and BMI are key potential predictors adopted in studies addressing CRF, therefore age was considered a confounder for the analysis of the association between anthropometric measures and CRF. All analyses were conducted in SPSS version 25…”

Section: Methodsmentioning

confidence: 99%

Factors Associated with Cardiorespiratory Fitness in Breast Cancer Survivors from the State of Santa Catarina, Brazil: Cross-Sectional Study

Boing

Raimundo

Pereira

et al. 2023

Rev. Bras. Cancerol.

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“…It may be the case that aromatase-mediated E2 increases physical activity in females whereas other factors (e.g., T) are more important regulators of physical activity in males. Human studies have also shown reduced physical activity specifically among women on AI ( 164 ). This finding likely has important clinical ramifications, as physical inactivity exacerbates musculoskeletal dysfunction, as mentioned above.…”

Section: Potential Remediation Strategies For Aromatase Inhibition-rementioning

confidence: 99%

Cognitive Effects of Aromatase and Possible Role in Memory Disorders

2018

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Diverse cognitive functions in many vertebrate species are influenced by local conversion of androgens to 17β-estradiol (E2) by aromatase. This enzyme is highly expressed in various brain regions across species, with some inter-species variation in terms of regional brain expression. Since women with breast cancer and men and women with other disorders are often treated with aromatase inhibitors (AI), these populations might be especially vulnerable to cognitive deficits due to low neuroE2 synthesis, i.e., synthesis of E2 directly within the brain. Animal models have been useful in deciphering aromatase effects on cognitive functions. Consequences of AI administration at various life cycle stages have been assessed on auditory, song processing, and spatial memory in birds and various aspects of cognition in rodent models. Additionally, cognitive deficits have been described in aromatase knockout (ArKO) mice that systemically lack this gene throughout their lifespan. This review will consider evidence to date that AI treatment in male and female rodent models, birds, and humans results in cognitive impairments. How brain aromatase regulates cognitive function throughout the lifespan, and gaps in current knowledge will be considered, along with future directions to better define how aromatase might guide learning and memory from early development through the geriatric period. Better understanding the importance of E2 synthesis on neurobehavioral responses at various ages will likely aid in the discovery of therapeutic strategies to prevent potential cognitive deficits, including Alzheimer's Disease, in individuals treated with AI or those possessing CYP19 gene polymorphisms, as well as cognitive effects of normal aging that may be related to changes in brain aromatase activity.

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Relationship between physical activity practice and metabolic profile of postmenopausal women under treatment with aromatase inhibitors for breast cancer

Cited by 2 publications

References 32 publications

Factors Associated with Cardiorespiratory Fitness in Breast Cancer Survivors from the State of Santa Catarina, Brazil: Cross-Sectional Study

Factors Associated with Cardiorespiratory Fitness in Breast Cancer Survivors from the State of Santa Catarina, Brazil: Cross-Sectional Study

Cognitive Effects of Aromatase and Possible Role in Memory Disorders

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