Relationship between physical fitness and lifestyle behaviour in healthy young men

Ortlepp, Jan R.; Metrikat, Jens; Albrecht, Marlies; Maya-Pelzer, P

doi:10.1097/01.hjr.0000131578.48136.85

Cited by 14 publications

(9 citation statements)

References 27 publications

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“…Although there was no exact measurement of physical fitness before the test, the present study demonstrated that inquiring into exercise habits of EMTs, including with frequency, duration, and total time spent in exercise per week, provided information that predicted highquality CPR on a manikin. Physical fitness is determined by the individual's lifestyle and behaviors, including exercise and physical activity [18]. Peterson et al [19] found a positive correlation between exercise habits and physical fitness as measured by maximal oxygen uptake.…”

Section: Discussionmentioning

confidence: 99%

Rescuer factors predict high-quality CPR—a manikin-based study of health care providers

Lin

Kuo

et al. 2016

The American Journal of Emergency Medicine

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Section: Discussionmentioning

confidence: 99%

Rescuer factors predict high-quality CPR—a manikin-based study of health care providers

Lin

Kuo

et al. 2016

The American Journal of Emergency Medicine

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“…28 There is also substantial evidence in animal models for a causal relationship between monocytosis and atherogenesis. 29–32 In mouse models of diet-induced atherosclerosis, the subset of Ly6C hi expressing monocytes expands with hypercholesterolemia and selectively enters sites of inflammation including atherosclerotic lesions, compared to the Ly6C lo subset. 33, 34 In addition, single gene mutations resulting in reduced blood monocytes also reduced atherosclerosis independent of plasma cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation

Kuo

Murphy

Sayers

et al. 2011

ATVB

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Objective Common genetic variants in a 58-kilobase region of chr 9p21, near the CDKN2A/CDKN2B tumor suppressor locus, are strongly associated with coronary artery disease. However, the underlying mechanism of action remains unknown. Methods and Results We previously reported a congenic mouse model harboring an atherosclerosis susceptibility locus and the region of homology with the human 9p21 locus. Microarray and transcript-specific expression analyses showed markedly decreased Cdkn2a expression, including both p16INK4a and p19ARF, but not Cdkn2b (p15INK4b), in macrophages derived from congenic mice compared to controls. Atherosclerosis studies in subcongenic strains revealed genetic complexity and narrowed one locus to a small interval including Cdkn2a/b. Bone marrow (BM) transplantation studies implicated myeloid lineage cells as the culprit cell type rather than resident vascular cells. To directly test the role of BM-derived Cdkn2a transcripts in atherogenesis and inflammatory cell proliferation, we performed a transplantation study utilizing Cdkn2a+/− cells in the Ldlr−/− mouse model. Cdkn2a-deficient BM recipients exhibited accelerated atherosclerosis, increased Ly6Chi pro-inflammatory monocytes and increased monocyte/macrophage proliferation compared to controls. Conclusions These data provide a plausible mechanism for accelerated atherogenesis in susceptible congenic mice, involving decreased expression of Cdkn2a and increased proliferation of monocyte/macrophages, with possible relevance to the 9p21 human locus.

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“…While atherosclerosis-associated inflammation might contribute to this relationship, there is also considerable evidence that leukocytosis directly enhances atherosclerosis and thrombosis (1). Numerous CVD risk factors -including obesity, smoking, sedentary lifestyles and metabolic syndrome (including individual components of metabolic syndrome, such as high triglycerides and low HDL) -are all associated with leukocytosis (2)(3)(4). While these associations have usually been made for total wbcs or neutrophils, monocytosis has also been specifically associated with CVD and with atherosclerotic plaque burden in both prospective and cross-sectional studies (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

Murphy¹,

Akhtari²,

Tolani³

et al. 2011

J. Clin. Invest.

451

532

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Leukocytosis is associated with increased cardiovascular disease risk in humans and develops in hypercholesterolemic atherosclerotic animal models. Leukocytosis is associated with the proliferation of hematopoietic stem and multipotential progenitor cells (HSPCs) in mice with deficiencies of the cholesterol efflux-promoting ABC transporters ABCA1 and ABCG1 in BM cells. Here, we have determined the role of endogenous apolipoprotein-mediated cholesterol efflux pathways in these processes. In Apoe -/-mice fed a chow or Western-type diet, monocytosis and neutrophilia developed in association with the proliferation and expansion of HSPCs in the BM. In contrast, Apoa1 -/-mice showed no monocytosis compared with controls. ApoE was found on the surface of HSPCs, in a proteoglycan-bound pool, where it acted in an ABCA1-and ABCG1-dependent fashion to decrease cell proliferation. Accordingly, competitive BM transplantation experiments showed that ApoE acted cell autonomously to control HSPC proliferation, monocytosis, neutrophilia, and monocyte accumulation in atherosclerotic lesions. Infusion of reconstituted HDL and LXR activator treatment each reduced HSPC proliferation and monocytosis in Apoe -/-mice. These studies suggest a specific role for proteoglycanbound ApoE at the surface of HSPCs to promote cholesterol efflux via ABCA1/ABCG1 and decrease cell proliferation, monocytosis, and atherosclerosis. Although endogenous apoA-I was ineffective, pharmacologic approaches to increasing cholesterol efflux suppressed stem cell proliferative responses.

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Relationship between physical fitness and lifestyle behaviour in healthy young men

Cited by 14 publications

References 27 publications

Rescuer factors predict high-quality CPR—a manikin-based study of health care providers

Rescuer factors predict high-quality CPR—a manikin-based study of health care providers

Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

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