Relationship between plaque mass and neointimal hyperplasia after stent placement in Yucatan micropigs.

Smet, Bart J. G. L. de; Kuntz, Richard E.; Helm, Yvonne J. van der; Pasterkamp, Gérard; Borst, Cornelius; Post, Mark J.

doi:10.1148/radiology.203.2.9114109

Cited by 16 publications

(11 citation statements)

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“…6,7 However, previous studies only report on the relationship between cross-sectional area of the plaque burden and cross-sectional area of the neointima formation. 6,7 No data exist as to whether the asymmetries in neointimal formation may be explained by the eccentricity of the persistent plaque burden. This subject warrants further study because in eccentric lesions, a confounding factor, such as progression of atherosclerosis at the low SS 21 side, may be present.…”

Section: Relation Between Ss and Thmentioning

confidence: 99%

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Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries

et al. 2001

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Background-In-stent restenosis by excessive intimal hyperplasia reduces the long-term clinical efficacy of coronary stents. Because shear stress (SS) is related to plaque growth in atherosclerosis, we investigated whether variations in SS distribution are related to variations in neointima formation. Methods and Results-In 14 patients, at 6-month follow-up after coronary Wallstent implantation, 3D stent and vessel reconstruction was performed with a combined angiographic and intravascular ultrasound technique (ANGUS). The bare stent reconstruction was used to calculate in-stent SS at implantation, applying computational fluid dynamics

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Section: Relation Between Ss and Thmentioning

confidence: 99%

“…3 A number of risk factors, such as thrombus formation 4 and endothelial dysfunction, 5 are related to restenosis, but their relationship with a specific intima hyperplasia distribution is unknown. Localizing factors that have been studied include plaque burden 6,7 and wall stress. 8 In the present study, we focus on the role of shear stress (SS).…”

mentioning

confidence: 99%

Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries

et al. 2001

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“…shown that this regimen results in a sustained tenfold We developed an atherosclerotic model in the Yucatan increase in the total cholesterol level to 14.9 (61.3) micropig [7] that meets most of these conditions. We found mmol / l, and an approximately 3.5-fold increase in the that the morphology of the atherosclerotic plaque covers high-density lipoprotein (HDL) level to 2.2 (60.1) mmol / the whole range from hypercellular fibromuscular plaque l. After discontinuation of the atherogenic diet, the levels to lipid lakes that are covered by a fibrous cap and of cholesterol and HDL cholesterol dropped to base levels complex lesions with calcification, cholesterol clefts and (1.560.2 and 0.660.1 mmol / l, respectively).…”

Section: Introductionmentioning

confidence: 99%

The atherosclerotic Yucatan animal model to study the arterial response after balloon angioplasty: the natural history of remodeling

Smet

Zande

Helm

et al. 1998

Cardiovascular Research

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Objective: Remodeling in de novo atherosclerosis and in restenosis after balloon angioplasty constitutes a change in total arterial circumference which, together with plaque growth or neointimal formation, determines the lumen of the artery. To better understand the fundamental biology of neointimal formation, remodeling and their interaction, animal studies are needed. In this study, we described in detail the methodology used and the natural history of neointimal formation and remodeling after balloon angioplasty in atherosclerotic Yucatan micropigs. Methods and results: Atherosclerosis was induced in 60 peripheral arteries of sixteen Yucatan micropigs by a combination of denudation and atherogenic diet. Balloon angioplasty was performed in 38 arteries, with serial intravascular ultrasound (IVUS) and quantitative angiography before and after intervention and at 2, 4, 7, 14 or 42 days follow-up. Remodeling, expressed as late media-bounded area (MBA) loss, increased progressively over time. At 42 days, late MBA loss after balloon angioplasty was significantly 2 different compared to late MBA loss in control arteries, 2.261.0 versus 20.361.1 mm and p50.02. Late lumen loss increased over time 2 and was highest at 42 days after balloon angioplasty (2.860.7 mm ). The contribution of neointimal formation to late lumen loss decreased over time and the contribution of late MBA loss to late lumen increased over time and was highest at 42 days (78%). Medial necrosis was 48% at two days after balloon angioplasty and the repopulation of the media was almost completed at seven days. Conclusion: Remodeling following balloon angioplasty has an early onset and progresses with neointimal formation to cause restenosis over the standard 42-day time course for Yucatan micropigs. This correlates to six months renarrowing in humans. In this model, atherosclerosis and the natural history of restenosis, both with respect to neointimal formation and remodeling, resemble the human disease quite closely.

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“…High-fat, high-cholesterol, and high-sugar diets have been shown to induce hyperlipidemia, obesity, and insulin resistance in humans and rodents [20][21][22]. Dietary-induced hyperlipidemia pig models have also been established [23][24][25][26][27][28][29].…”

Section: Gene Expression Profiles Change Related To Hyperlipidemiamentioning

confidence: 99%

Whole Blood RNA Analysis, Aging and Disease

Takahashi¹,

Takatsu²,

Misawa³

et al. 2012

Blood Cell - An Overview of Studies in Hematology

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Relationship between plaque mass and neointimal hyperplasia after stent placement in Yucatan micropigs.

Abstract: The amount of plaque present before stent placement was a determinant of the amount of intimal hyperplasia present after stent placement.

Cited by 16 publications

References 0 publications

Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries

Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries

The atherosclerotic Yucatan animal model to study the arterial response after balloon angioplasty: the natural history of remodeling

Whole Blood RNA Analysis, Aging and Disease

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