Relationship between plasma apelin level and coronary collateral circulation

Akboğa, Mehmet Kadri; Akyel, Ahmet; Şahinarslan, Asife; Yılmaz, Canan; Yayla, Çağrı; Boyacı, Bülent; Yalçın, Rıdvan

doi:10.1016/j.atherosclerosis.2014.04.029

Cited by 31 publications

(17 citation statements)

References 35 publications

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“…Thus, in light of clinical entities, such as "metabolically healthy" obesity phenotypes and the "obesity paradox" (52), our findings emphasize the consideration of visceral adiposity rather than BMI as a more adequate indicator of collateral development, which plays a major role in cardiovascular outcomes and survival (3,5,7,13). Similarly, in a communitybased cross-sectional study regarding obesity indices and myocardial infarction, VFI (optimal cut-off values of 15 for males and 10 for females) was shown to be associated with higher predictive power and higher sensitivity than BMI and waist circumference in the identification of CVD risk in both sexes (53).…”

Section: Discussionmentioning

confidence: 81%

“…The presence of metabolic syndrome (31)(32)(33), an increasing number of components of metabolic syndrome (33,34), aging (15), obesity (18) and the presence of hypertension (20,35) have been associated with an increased risk of impaired collateral development among patients with obstructive CAD. However, there is controversy regarding the impact of diabetes or smoking on collateral development, with associations of diabetes (10,11) and nonsmoking (20) with a higher risk of poor collateral development shown in some studies, whereas no associations of diabetes (36) or smoking (13) with collateral growth and an association of inflammation with either promoted or inhibited collateral growth (37) have been reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Given that coronary collateral growth depends on intact vascular endothelium and endothelial function, factors contributing to vascular dysfunction have also been suggested to be associated with poor CCC (10)(11)(12). Accordingly, genetic factors, age, degree of coronary artery stenosis, presence of total occlusion, myocardial ischemia, severe multivessel coronary stenosis, physical exercise, smoking, obesity, hyperlipidemia, diabetes mellitus and metabolic syndrome have been proposed to be related to coronary collateral development in several studies (10,(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

“…However, while many pathogenic insults have been proposed, given the existence of conflicting data, the exact mechanism of CCC has not yet been completely described (7,11,13,(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Visceral fat index: a novel predictor for coronary collateral circulation

Şahintürk¹,

Küçükseymen²,

Avcı³

et al. 2020

Archives of Endocrinology and Metabolism

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Objective: This study was designed to investigate the role of visceral adiposity along with other clinical parameters in predicting poor coronary collateral circulation (CCC) among patients with severe obstructive coronary artery disease (CAD). Subjects and methods: A total of 135 patients with severe obstructive CAD and good (n = 70) or poor (n = 65) CCC were included. Data on angiographically detected CCC, the quality criteria for CCC (Rentrop scores) and visceral fat index (VFI) obtained via bioelectrical impedance were compared between good and poor CCC groups. Independent predictors of poor CCC, the correlation between VFI and Rentrop score and the role of VFI in the identification of CCC were analyzed. Results: A significant negative correlation was noted between VFI and Rentrop scores (r = -0.668, < 0.001). The presence of hypertension (OR 4.244, 95% CI 1.184 to 15.211, p = 0.026) and higher VFI (OR 1.955, 95% CI 1.342 to 2.848, p < 0.001) were shown to be independent predictors of an increased risk for poor CCC. ROC analysis revealed a VFI > 9 (AUC [area under the curve] (95% CI): 0.898 (0.834-0.943), p < 0.0001) to be a potential predictor of poor CCC with a sensitivity of 95.38% and specificity of 85.71%. Conclusion: In conclusion, our findings revealed comorbid hypertension and higher VFI to significantly predict the risk of poor CCC in patients with severe obstructive CAD.Arch Endocrinol Metab. 2020;64(2):150-8

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, while many pathogenic insults have been proposed, given the existence of conflicting data, the exact mechanism of CCC has not yet been completely described (7,11,13,(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Visceral fat index: a novel predictor for coronary collateral circulation

Şahintürk¹,

Küçükseymen²,

Avcı³

et al. 2020

Archives of Endocrinology and Metabolism

View full text Add to dashboard Cite

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“…However, compared with patients diagnosed with chronic cerebral ischaemia, patients with MDD have greater capacities for arteriogenesis and angiogenesis as well as better clinical prognoses and outcomes 5 . Many studies have shown that apelin is closely related to angiogenesis 6–8 and promotes angiogenesis after ischaemic stroke 9 .…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of the diagnostic value of plasma apelin 12 levels for differentiating patients with moyamoya and intracranial atherosclerotic diseases

Jiang

et al. 2017

Sci Rep

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Patients with moyamoya disease (MMD) or intracranial atherosclerotic disease (ICAD) experience similar cerebral ischaemic events. However, MMD patients show greater angiogenesis and arteriogenesis, which play crucial roles in collateral circulation development to enhance clinical prognosis and outcome. Apelins have been associated with angiogenesis and arteriogenesis. Therefore, the aim of the present study was to determine whether apelin levels were higher in patients with MMD than in patients with ICAD or in healthy controls. We compared plasma apelin levels in 29 patients with MMD, 82 patients with ICAD, and 25 healthy participants. Twelve-hour fasting blood samples were collected and analysed using commercially available kits. Univariate analyses indicated that compared with the ICAD and healthy control groups, the MMD group had higher apelin-12, apelin-13, apelin-36, and nitric oxide levels. Binary logistic regression analyses further showed that the plasma apelin-12 level was substantially higher in MMD patients than in ICAD patients. Patients with MMD were also differentiated from patients with ICAD by their mean ages, with the former being younger. Therefore, the plasma apelin-12 level is a potential diagnostic marker for differentiating MMD and ICAD and may provide a treatment strategy for enhancing collateral circulation development and clinical prognosis and outcome.

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Endocan: a novel biomarker associated with well-developed coronary collateral circulation in patients with stable angina and chronic total occlusion

Emet

Elıtok

Onur

et al. 2016

J Thromb Thrombolysis

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Angiogenesis and arteriogenesis have a crucial role in the formation of coronary collateral vessels. It has been shown that endocan and vascular cell adhesion molecule-1 (VCAM-1) are potential angiogenetic factors. We investigated the relationship between serum endocan levels and grade of coronary collaterals, and also the correlation of endocan levels with serum VCAM-1 levels. Patients with stable angina and at least one total coronary occlusion at invasive coronary angiography were included in our study. Collateral degree was graded according to Rentrop and Cohen's classification. Patients who had grade 0 or 1 collateral vessels were included in the poorly-developed collateral group, and those with grade 2 or 3 coronary collateral vessels were included in the well-developed collateral group. Serum endocan and VCAM-1 levels were significantly higher in the well-developed collateral group (436.6 ± 213.3 ng/mL vs. 216.1 ± 78.5 ng/mL, p < .001; 11.02 ± 6.58 ng/mL vs. 6.78 ± 1.14 ng/mL, p < .001, respectively). In a logistic regression analysis, only serum endocan level remained as an independent predictor for good collateral development. In the ROC curve analysis, 282 ng/mL endocan level had an a 82 % sensitivity and 86 % specificity for prediction of the well-developed collateral group. Higher endocan level was related to better coronary collateral development. In the event that these results are confirmed in further studies, endocan may be considered as an anti-ischemic treatment strategy in order to improve collateral development.

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Relationship between plasma apelin level and coronary collateral circulation

Cited by 31 publications

References 35 publications

Visceral fat index: a novel predictor for coronary collateral circulation

Visceral fat index: a novel predictor for coronary collateral circulation

Prospective evaluation of the diagnostic value of plasma apelin 12 levels for differentiating patients with moyamoya and intracranial atherosclerotic diseases

Endocan: a novel biomarker associated with well-developed coronary collateral circulation in patients with stable angina and chronic total occlusion

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