Relationship Between Plasma Aripiprazole and Dehydroaripiprazole Concentrations and Prolactin Levels in Chinese Children and Adolescents

Ma, Botao; Zhao, Weihua; Fan, Hongzhen; Yun, Yajun; Qi, Siyuan; An, Huimei; Yang, Fude

doi:10.1089/cap.2022.0068

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…In this regard, achieving optimal therapeutic outcomes of aripiprazole requires the precise monitoring of plasma concentrations. In this sense, accurate quantification of aripiprazole is crucial for tailoring treatment strategies to individual patient needs, minimizing adverse effects and optimizing therapeutic efficacy [ 11 , 12 ]. Liquid chromatographic methods for the analysis of aripiprazole are widely described in the literature: there are LC-MS/MS [ 13 , 14 , 15 , 16 ], HPLC-UV/DAD [ 17 , 18 , 19 ] or GC-MS [ 20 ]-based methods.…”

Section: Introductionmentioning

confidence: 99%

Towards Precision Medicine in Clinical Practice: Alinity C vs. UHPLC-MS/MS in Plasma Aripiprazole Determination

Toja-Camba,

Bandín-Vilar,

Hermelo-Vidal

et al. 2024

Pharmaceutics

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Therapeutic drug monitoring improves the benefit–risk balance of antipsychotic therapy. Ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) is considered the gold-standard method for measuring plasma drug concentrations; however, the Alinity C system has emerged as a promising alternative. This is the first study aimed at comparing UHPLC-MS/MS versus Alinity C in measuring plasma concentrations of aripiprazole and dehydroaripiprazole. A total of 86 plasma samples were analyzed. The active moiety of aripiprazole was measured in 60 samples using both systems and 26 samples were analyzed twice using Alinity C with an intermediate period of 6 months to assess its reproducibility. Spearman’s correlation revealed a good association between the two assays (rs = 0.96) and no significance differences were found by McNemar’s test when classifying samples between infra-, supra- and therapeutic ranges. Passing–Bablock regression showed a good correlation among methods (rs = 0.93) and a slope of 1.12 indicating a slight tendency of Alinity C to measure higher values than UHPLC-MS/MS. In addition, a good intra-method correlation across the two sequential analyses with Alinity C was obtained (rs = 0.99). Nonetheless, clinical decisions could be different in 15% of the cases depending on the chosen method. No differences were found in active moiety determination by Alinity C depending on the concentration of aripiprazole and dehydroaripiprazole of the samples.

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