Relationship between Plasma Hypoxia Inducible Factor 1α in Type 2 Diabetes Mellitus with Malignancy and Without Malignancy

Abstract

BACKGROUND: Diabetes mellitus was associated with hypoxia condition and result ischemia and induced neovascularization and other forms of the cell adaptation in response to the tissue concentrations of low oxygen levels. Hypoxia-Inducible Factor 1 alpha a marker of the cell adaptation as a hypoxic cell response which was due of chronic hiperglycemia.
 AIM: The aim of this study to know the relationship between Hba1c and plasma HIF-1 α level at type 2 diabetes mellitus patients.
 METHODS: The cross-sectional study design using the 89 samples of diabetes mellitus patients who attended Murni Teguh Hospital in Medan of Indonesia country. The inclusion criteria of the samples were all the patients diagnosed with type 2 diabetes mellitus both the sexes. Body mass index, blood pressure, and disease history six socioeconomic status was recorded. The laboratory parameters, including fasting blood sugar and Hba1c were examined by Murni Teguh Hospital Laboratory.
 RESULTS: The result of the study we found that there was no significant difference the hypoxia-inducible factor 1α level (HIF-1α) at type 2 diabetes mellitus with malignancy was higher compared at type 2 diabetes mellitus without malignancy.
 CONCLUSION: The patient’s type 2 diabetes mellitus with the high HIF-1α levels have a poor prognosis compared with the lower levels because the high HIF-1α will tend to have a risk complication of malignancy or the other complication of diabetes mellitus.

Relation of Hypoxia Inducible Factor, Dyslipidemia and CAD Saudi Patients With Type 2 Diabetes

“…Rusdiana et al, (37) revealed that patients with T2DM who have increased HIF-1α levels have a worse prognosis than those who have lower concentrations because high HIF-1α increases the risk of cancer and diabetic complications. Higher blood HIF-1α concentrations may play a role in vascular calcification in T2DM.…”

Hypoxia-Inducible Factors and Diabetic Kidney Disease—How Deep Can We Go?

“…All these studies might support the major role of HIF-1α level as an independent risk factor in vascular and valvular calcification, making it a potential therapeutic target for preventing cardiovascular events in CKD patients [ 1 , 65 , 66 ].…”

“…Li G et al also showed that elevated serum HIF-1α may contribute to coronary artery calcification (CAC) by CT scanning data analysis of 405 asymptomatic patients with type 2 diabetes mellitus, showing 61.1% sensitivity and 87.6% specificity for predicting CAC extent in this special group of patients [ 66 ].…”

Effect of umbilical cord mesenchymal stem cells on hypoxia-inducible factor-1 alpha (HIF-1α) production in arteriovenous fistula (AVF) animal model: A preliminary study

“…H ypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that plays a crucial role in angiogenesis [ 1 ] and cellular responses to hypoxia [ 2 ]. During hypoxic condition, HIF-1α is stabilized and enters the nucleus to bind to other cofactors and activates the hypoxia response element of certain gene promoters [ 2 ].…”

“…One such pathway involves in the development of intimal hyperplasia (IH), a condition characterized by the thickening of the inner lining of blood vessels, which is a common complication in arteriovenous fistula (AVF) creation [ 3 ]. In the case of AVF creation, the local oxygen diffusion from the arterial lumen may be insufficient due to intimal thickening and inflammation, resulting in a hypoxic environment that leads to the overexpression of HIF-1α [ 1 ].…”