Relationship between plasma osteocalcin, glycaemic control and components of metabolic syndrome in adult Nigerians with type 2 diabetes mellitus

Onyenekwu, Chinelo P; Azinge, Elaine Chinyelu; Egbuagha, E U; Okpara, Henry Chima

doi:10.1016/j.dsx.2016.12.013

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…Given that the serum levels of osteocalcin differ between sexes and alter with age, the relationship of serum osteocalcin levels with CVD risk may also differ according to these variables ( 37 ). Studies have demonstrated that close correlations of serum osteocalcin level with glucose and lipid metabolic disorders, obesity, and MetS ( 8 , 38 ). Herein, the serum N-MID level was correlated with CRP, FBG, HbA1C, HDL-C, and TG after adjusting for age and sex.…”

Section: Discussionmentioning

confidence: 99%

Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus

Liu

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveThis study aimed to investigate the association of serum bone turnover markers (BTMs) with metabolic syndrome components and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM).MethodsWe performed a cross-sectional based study in T2DM populations. Serum BTMs including N-terminal osteocalcin (N-MID), β-cross-linked C-telopeptide of type I collagen (β-CTX), and procollagen type I N-terminal propeptide (PINP) were measured by immunoassay method. Carotid artery intima-media thickness and carotid artery plaque (CAP) were measured by B-mode ultrasound.ResultsThe serum N-MID, PINP, and β-CTX levels significantly lower in the CAP group compared with the non-CAP group. N-MID and PINP levels were inversely associated with fasting blood glucose, HOMA-IR, CRP, eGFR, and triglycerides (all P < 0.05), whereas β-CTX levels were negatively associated with triglycerides (P < 0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher for CAP with decreased N-MID level (OR = 0.958; 95% CI = 0.926–0.991; P = 0.013). However, serum levels of PINP and β-CTX were not associated with the presence of CAP. Multivariate logistic regression analysis further revealed that serum N-MID, PINP, and β-CTX levels were significantly associated with hypertriglyceridemia, whereas serum N-MID and β-CTX levels were associated with overweight/obesity risk.ConclusionsThese findings indicated that serum N-MID level was an independent risk factor for carotid atherosclerosis, whereas BTM levels were associated with other metabolic syndrome components in a T2DM population.

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Section: Discussionmentioning

confidence: 99%

Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus

Liu

et al. 2022

Front. Cardiovasc. Med.

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“…In these studies, the prevalence of MetS was estimated based on the IDF and/or NCEP-ATP III 2004 criteria. Among the articles, eleven studies reported the prevalence of MetS based on both NCEP-ATP III 2004 and IDF criteria [ 33 , 39 – 41 , 44 – 46 , 49 , 50 , 52 , 54 ], fourteen studies reported based solely on NCEP-ATP III 2004 criteria [ 26 , 27 , 29 – 32 , 34 , 36 , 37 , 42 , 43 , 47 , 51 , 53 ], and five studies reported based on IDF criteria alone [ 25 , 28 , 35 , 38 , 48 ]. Additionally, nine studies reported the prevalence of MetS subcomponents based on NCEP-ATP III 2004 criteria [ 26 , 27 , 32 , 36 , 41 – 45 ] and six studies based on IDF criteria [ 25 , 28 , 41 , 44 , 45 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring the Prevalence and Components of Metabolic Syndrome in Sub-Saharan African Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis

Musilanga,

Nasib,

Jackson

et al. 2024

Journal of Obesity

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Background. Type 2 diabetes mellitus and metabolic syndrome represent two closely intertwined public health challenges that have reached alarming epidemic proportions in low- and middle-income countries, particularly in sub-Saharan Africa. Therefore, the current study aimed to determine the weighted pooled prevalence of metabolic syndrome and its components among individuals with type 2 diabetes mellitus in sub-Saharan Africa as defined by the 2004 National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP III 2004) and/or the International Diabetes Federation (IDF) criteria. Methods. A systematic search was conducted to retrieve studies published in the English language on the prevalence of metabolic syndrome among type 2 diabetic individuals in sub-Saharan Africa. Searches were carried out in PubMed, Embase, Scopus, Google Scholar, African Index Medicus, and African Journal Online from their inception until July 31, 2023. A random-effects model was employed to estimate the weighted pooled prevalence of metabolic syndrome in sub-Saharan Africa. Evidence of between-study variance attributed to heterogeneity was assessed using Cochran’s Q statistic and the I2 statistic. The Joanna Briggs Institute quality appraisal criteria were used to evaluate the methodological quality of the included studies. The summary estimates were presented with forest plots and tables. Publication bias was checked with the funnel plot and Egger’s regression test. Results. Overall, 1421 articles were identified and evaluated using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, and 30 studies that met the inclusion criteria were included in the final analysis. The weighted pooled prevalence of metabolic syndrome among individuals with type 2 diabetes mellitus in sub-Saharan Africa was 63.1% (95% CI: 57.9–68.1) when using the NCEP-ATP III 2004 criteria and 60.8% (95% CI: 50.7–70.0) when using the IDF criteria. Subgroup analysis, using NCEP-ATP III 2004 and IDF criteria, revealed higher weighted pooled prevalence among females: 73.5% (95% CI: 67.4–79.5), 71.6% (95% CI: 60.2–82.9), compared to males: 50.5% (95% CI: 43.8–57.2), 44.5% (95% CI: 34.2–54.8), respectively. Central obesity was the most prevalent component of metabolic syndrome, with a pooled prevalence of 55.9% and 61.6% using NCEP-ATP III 2004 and IDF criteria, respectively. There was no statistical evidence of publication bias in both the NCEP-ATP III 2004 and IDF pooled estimates. Conclusions. The findings underscore the alarming prevalence of metabolic syndrome among individuals with type 2 diabetes mellitus in sub-Saharan Africa. Therefore, it is essential to promote lifestyle modifications, such as regular exercise and balanced diets, prioritize routine obesity screenings, and implement early interventions and robust public health measures to mitigate the risks associated with central obesity.

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“…The role of OCN in glucose and energy metabolism was also shown in several cross-sectional and observational studies in humans, indicating inverse relation of total OCN (tOCN) and/or uOCN with fasting blood glucose (FBG), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index, and adiposity; however, a positive correlation of OCN with serum adiponectin and insulin secretion was observed in non-diabetic, pre-diabetic, and diabetic populations (8)(9)(10).…”

Section: Introductionmentioning

confidence: 81%

Endokrinoloji Poliklinik Hastalarında Cinsiyet, Menopoz Durumu ve Glukoz Toleransının Osteokalsin Seviyeleri Üzerindeki Etkileri: Bir Vaka-Kontrol Çalışması

KARCI>¹,

KARCİ²,

Çetinarslan³

2021

Batı Karadeniz Tıp Dergisi

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menopausal status, and glucose tolerance in endocrinology outpatients. Material and Methods: A total of 178 endocrinology outpatients with oral glucose tolerance test (OGTT) findings were included. Data on anthropometrics [body mass index (BMI), waist circumference (cm), body fat percentage (BFP), and fat mass], glycemic parameters [fasting blood glucose (FBG), insulin), C-peptide, HbA1c, and insulin resistance (HOMA-IR)], blood lipids, and serum osteocalcin (OCN) levels [total osteocalcin (tOCN) and uncarboxylated osteocalcin (uOCN)] were compared with sex, menopausal status, and glucose tolerance status. Results: No significant difference was noted in the tOCN and uOCN levels concerning gender and menopausal status. tOCN was negatively correlated with BMI, waist circumference, BFP, and fat mass in patients with normal glucose tolerance (p

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Relationship between plasma osteocalcin, glycaemic control and components of metabolic syndrome in adult Nigerians with type 2 diabetes mellitus

Cited by 8 publications

References 37 publications

Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus

Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus

Exploring the Prevalence and Components of Metabolic Syndrome in Sub-Saharan African Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis

Endokrinoloji Poliklinik Hastalarında Cinsiyet, Menopoz Durumu ve Glukoz Toleransının Osteokalsin Seviyeleri Üzerindeki Etkileri: Bir Vaka-Kontrol Çalışması

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