Relationship between plasma resistin concentrations, inflammatory chemokines, and components of the metabolic syndrome in adults

Aquilante, Christina L.; Kosmiski, Lisa A.; Knutsen, Shannon D; Zineh, Issam

doi:10.1016/j.metabol.2007.11.010

Cited by 73 publications

(52 citation statements)

References 30 publications

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“…[20][21][22][23][24][25][26][27] Proinflammatory molecules such as tumor necrosis factor-a, interleukin-6 and lipopolysaccharide regulate resistin gene expression in various cell models 28 and reciprocal modulation has been hypothesized. 29 Resistin is clearly involved in inflammation, but its specific function in that situation remains to be clarified.…”

Section: Introductionmentioning

confidence: 99%

“…33 Most studies also found an increase in resistin in obese adults when compared to lean groups with a positive correlation between resistin and obesity indices. 4,29,31,[33][34][35] Because of its link with obesity and inflammation and its potential link with insulin resistance, resistin has been tagged as a potential metabolic syndrome (MetS) marker. Supporting this theory, adults with MetS tend to have higher resistin levels than their healthy counterparts.…”

Section: Introductionmentioning

confidence: 99%

“…Supporting this theory, adults with MetS tend to have higher resistin levels than their healthy counterparts. 29 However, the correlation between insulin resistance and plasma resistin in adult humans remains controversial, supported by some studies 25,[35][36][37] and not in others, 4,21,34,38,39 and this therefore weakens the relation between resistin and MetS.…”

Section: Introductionmentioning

confidence: 99%

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Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents

Fisette

et al. 2009

Int J Obes

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Objective: Resistin has been linked with obesity and hypothesized as a potential marker of insulin resistance in addition to being linked with acute inflammation. However, these links are still highly controversial in humans. Our goal was to examine resistin levels in relation to obesity, insulin resistance and inflammation markers in a large population of Asian children and adolescents. Methods: Children and adolescents (n ¼ 3472) aged 6-18 years, boys (n ¼ 1765) and girls (n ¼ 1707), were assessed for body size parameters, pubertal development, blood lipids, glucose, insulin, resistin, C-reactive protein (CRP), adiponectin and complement C3 (C3) levels. Results: Resistin increased with central obesity in both genders but not with simple adiposity in boys. Several markers associated with central obesity correlated in a gender-specific fashion with plasma resistin. Waist circumference, fat-mass percentage, waistto-height ratio and body mass index (BMI) positively correlated with resistin in both genders. Blood lipids such as triglycerides, nonesterified fatty acids (NEFA) and low-density lipoprotein cholesterol, diastolic and systolic blood pressure correlated positively with resistin in boys. NEFA, high-density lipoprotein cholesterol (negatively) and inflammation markers, such as CRP and C3, positively correlated with resistin in girls. There was no correlation between resistin and adiponectin, and no association of adiponectin with resistin quintiles in either boys or girls. In both boys and girls, resistin tended to decrease with age, with girls having higher levels than boys. Few indices of insulin resistance were linked with plasma resistin in either gender. Conclusion: In this population, plasma resistin levels are a weak biochemical marker of metabolic dysfunction defined by central obesity, adiposity and inflammation and does not predict insulin resistance. Only a small proportion of resistin variation can be explained by factors related to metabolic syndrome, suggesting that resistin is not strongly implicated in a concentrationdependent fashion in any of the examined pathologies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents

Fisette

et al. 2009

Int J Obes

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“…Moreover, proinflammatory cytokines (interleukin (IL)1, IL6, and tumor necrosis factor-a (TNF)) could increase resistin expression in human peripheral blood mononuclear cells (PBMCs) (15), and meanwhile recombinant resistin also triggers the release of these proinflammatory cytokines in human PBMCs (16). Human population studies also showed that resistin levels were associated positively with leukocytes (10,17), C-reactive protein (CRP) (10,(18)(19)(20), IL6, and tumor necrosis factor-a receptor 2 (TNFR2) (21). In addition, resistin was found to upregulate the expression of cytokines and adhesion molecules in human endothelial cells (22,23).…”

Section: Introductionmentioning

confidence: 99%

Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese

Wang

et al. 2008

European Journal of Endocrinology

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Objective: Resistin increases insulin resistance (IR) in mice. However, the role of resistin in human disease remains controversial. We aimed to assess plasma resistin levels and their associations with inflammatory and fibrinolytic markers, IR and metabolic syndrome (MetS) among Chinese. Design and methods: Plasma resistin was measured in a population-based cross-sectional survey of 3193 Chinese aged from 50 to 70 years in Beijing and Shanghai. Results: The median resistin concentration was 8.60 ng/ml (interquartile range, 5.78-14.00) among all participants, and it was higher in women than in men (PZ0.008). Resistin was correlated weakly with body mass index, waist circumference, high-density lipoprotein (HDL) cholesterol (negatively), homeostatic model assessment of IR and tumor necrosis factor-a receptor 2 (TNFR2; rZ0.04, 0.07, -0.09 and 0.06 respectively, all P!0.05), and more highly with C-reactive protein (CRP), interleukin (IL)6 and plasminogen activator inhibitor (PAI)1 (rZ0.12, 0.12 and 0.21 respectively, all P!0.001), but only HDL cholesterol, CRP, IL6, TNFR2, and PAI1 remained significantly associated with resistin in multiple regression analysis (all P!0.05). Furthermore, elevated resistin levels were associated with the higher prevalence of IR and MetS. However, the significant relationships disappeared after adjustment for inflammatory and fibrinolytic markers especially PAI1. Conclusions: This study suggests that resistin is more strongly associated with inflammatory and fibrinolytic markers than with obesity or IR status. The associations of resistin with IR and MetS could largely be explained by inflammatory and fibrinolytic markers especially PAI1 levels.European Journal of Endocrinology 159 585-593

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“…In a human study, experimental endotoxemia caused a hyperresistinemic state [42]. In light of this, cytokines have been proposed to increase the levels of resistin, which may contribute to insulin resistance in obesity and several other inflammatory disorders [38,[46][47][48][49][50][51][52][53][54]. Potential roles for resistin in obesity, inflammatory, and other related diseases are shown in Figure 2.…”

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confidence: 99%

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

375

297

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Relationship between plasma resistin concentrations, inflammatory chemokines, and components of the metabolic syndrome in adults

Cited by 73 publications

References 30 publications

Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents

Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents

Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese

The role of resistin as a regulator of inflammation: Implications for various human pathologies

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