Relationship between Plasma Retinol and Infectious Diseases in the Elderly

Chau, Nearkasèn; Tebi, A.; Créton, Christine; Belbraouet, Slimane; Debry, G

doi:10.1159/000046693

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Plasma retinol levels are lower in patients with infectious disease rather than other disease types ( Chau et al, 2000 ). Whether this is a cause or an effect of infection (or more likely both) is difficult to unpick.…”

Section: Vitamin a Deficiency As A Risk Factor For Tuberculosis: Epid...mentioning

confidence: 99%

All trans retinoic acid as a host-directed immunotherapy for tuberculosis

Bahlool

Grant

Cryan

et al. 2022

Current Research in Immunology

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Section: Vitamin a Deficiency As A Risk Factor For Tuberculosis: Epid...mentioning

confidence: 99%

All trans retinoic acid as a host-directed immunotherapy for tuberculosis

Bahlool

Grant

Cryan

et al. 2022

Current Research in Immunology

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“…43,44 Asimismo, la concentración sérica baja de retinol se asocia con la presencia de enfermedades infecciosas en adultos mayores. 45 Desafortunadamente, las infecciones severas ocasionan un incremento en la excreción de retinol a través de la orina y la depleción de su almacenamiento. 46,47 Se ha documentado que los adultos en cuidados intensivos por neumonía pierden hasta tres veces la ingesta diaria recomendada (IDR) de vitamina A.…”

Section: Vitamina a E Infecciones Viralesunclassified

Participación de la vitamina A en la producción de IgA secretora en el epitelio del tracto respiratorio para la potencial protección de infección por SARS-CoV-2

Turrubiates-Hernández

Hernández‐Bello

Edith

et al. 2021

RAM

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El SARS-CoV-2 continúa infectando a miles de personas a nivel mundial. Se ha establecido que el principal mecanismo de transmisión del SARS-CoV-2 es por vía aérea, por lo que infecta inicialmente el tracto respiratorio. Actualmente, la eficacia de los fármacos utilizados contra COVID-19 es limitada y a pesar de que los programas de inmunización han iniciado, existe una desigualdad internacional en la distribución de vacunas. En este sentido, la búsqueda de terapias coadyuvantes continúa siendo una alternativa para su investigación. La suplementación con vitamina A se ha asociado con la reducción de mortalidad por infecciones; este efecto podría ser mediado por el ácido retinoico (AR), un metabolito activo de esta vitamina, que ejerce funciones inmunomoduladoras. De acuerdo con estudios preclínicos, el AR favorece la producción de inmunoglobulina A (IgA) secretora en el tracto respiratorio. Aunado a esto, la proteína de unión a retinol se ha correlacionado con la concentración de IgA y anticuerpos neutralizantes en pacientes con influenza. Por lo tanto, la presente revisión tiene como objetivo abordar la participación de la vitamina A en la producción de la inmunoglobulina A secretora en el epitelio del tracto respiratorio para resaltar su potencial función protectora contra la infección por SARS-CoV-2.

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Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs

Rockwell¹,

Liu²,

Mayne³

et al. 2011

Exp Biol Med (Maywood)

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Cancer patients often have subclinical vitamin A deficiencies and low vitamin A lung levels. Previous studies showed that subclinical vitamin A deficiency increased the severity of pneumonitis induced by whole-lung irradiation in rats. Many studies have shown that lung irradiation increases the number of lung tumors developing from intravenously injected tumor cells in mice. We examined the impact of vitamin A deficiency on the development of lung metastases from a highly metastatic syngeneic rat rhabdomyosarcoma in normal rats and rats receiving prior lung irradiation. Weanling female WAGrijY rats were randomized to receive either a diet lacking both vitamin A and beta-carotene or a control diet. After five weeks, the deficient diet significantly decreased levels of retinol in the lung and liver but not in the serum, modeling the tissue and blood levels seen in prior studies of patients with subclinical vitamin A inadequacy. The vitamin A-deficient diet did not alter the number of lung tumors developing from intravenously injected tumor cells in unirradiated rats. Whole-lung irradiation produced dose-dependent increases in the number of lung tumors developing from tumor cells injected intravenously one or 29 d after irradiation. Vitamin A deficiency did not alter these dose–response curves, indicating that the more intense radiation-induced pneumonitis seen previously in vitamin A-deficient rats did not alter the enhancement of metastases produced by whole-lung irradiation. Moreover, inadequate vitamin A intake did not influence the growth of tumors implanted subcutaneously or increase the number or size of the spontaneous lung metastases developing from these subcutaneous tumors. Thus, although low vitamin A status influences the development of lung injury and is considered a possible modifiable risk factor increasing risk of primary cancer, it did not affect the growth of subcutaneous tumors or increase the development of artificial or spontaneous lung metastases in this rat model.

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Relationship between Plasma Retinol and Infectious Diseases in the Elderly

Cited by 4 publications

References 37 publications

All trans retinoic acid as a host-directed immunotherapy for tuberculosis

All trans retinoic acid as a host-directed immunotherapy for tuberculosis

Participación de la vitamina A en la producción de IgA secretora en el epitelio del tracto respiratorio para la potencial protección de infección por SARS-CoV-2

Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs

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