Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction

Hu, Feng; Lü, Feng; Huang, Xiao; Cheng, Xiaoshu

doi:10.2147/ijgm.s338938

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…[30] Similar trials have demonstrated that elevated Hcy levels in patients with AMI are independent of other risk factors and are associated with a higher incidence of coronary events. [31] The present study is in agreement with the results of most studies that high Hcy can exacerbate coronary artery disease and that serum Hcy levels had an important prognostic value for the long-term prognosis of patients with NSTEMI.…”

Section: Discussionsupporting

confidence: 92%

Effect of hyperhomocysteine in patients after PCI for non-ST-segment elevation myocardial infarction, a retrospective study

Lan,

Gong

2024

Preprint

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Background The prognostic value of homocysteine (HCY) in patients with coronary artery disease (CAD) remains controversial. The aim of this study was to investigate whether an elevated HCY level on admission can predict long-term outcomes in patients with Non-ST-Segment elevation myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI) with coronary artery stenting.Methods From Jinshan Hospital Affiliated to Fudan University from January 2018 to December 2021, 275 patients who were diagnosed with NSTEMI and successfully underwent emergency PCI were conducted. All these patients were divided into two groups according to fasting plasma HCY levels the day after the theterization: group Ⅰ (142 patients, <15 µmol/L) and group II (127 patients, ≥ 15 µmol/L).Primary and secondary outcome measures: The primary endpoint was the occurrence of major adverse cardiac events (MACE), including cardiac death, non-fatal myocardial infarction, stroke, and new lesion stenting.Results After a mean follow-up of 36 ± 14 months, patients in group II had a higher rate of MACE (33.9% vs. 17.6%, p = 0.002). The main difference between the two groups was cardiac death (8.7% vs. 2.1%, p = 0.016). The risk of long-term MACE remained significantly higher in patients with elevated HCY levels (≥ 15 µmol/L) with a hazard ratio of 1.29 (95% CI, 1.1-12.23, p = 0.034). Elevated HCY levels (≥ 15 µmol/L) were independently associated with an increased risk of long-term cardiovascular events in patients after PCI.Conclusion Thus, hyperhomocysteinemia may remain a useful prognostic marker for risk assessment in the clinical management of CAD patients.

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Section: Discussionsupporting

confidence: 92%

Effect of hyperhomocysteine in patients after PCI for non-ST-segment elevation myocardial infarction, a retrospective study

Lan,

Gong

2024

Preprint

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“…The TIMI frame count for the LAD was divided by 1.7 to receive the cTFC in the LAD. The authors defined CSF as greater than 27 frames per second in any of the three coronary arteries, as described previously [14,15].…”

Section: Corrected Timi Frame Count Calculationmentioning

confidence: 99%

Coronary slow flow is not an adverse prognostic factor in MINOCA patients in the 5-year follow-up

Buller¹,

Witkowski

Tyczyński

et al. 2023

Medical Research Journal

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Introduction:The research aimed to compare the characteristics and outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) patients with coronary slow flow (CSF) vs. normal coronary flow (no CSF) in a 5-year follow-up.Material and methods: Between 2010-2015 were identified 111 patients as having final MINOCA diagnosis and available calculated corrected TIMI frame count (cTFC). CSF was defined as cTFC greater than 27 frames per second in any of the three coronary arteries. The primary endpoint was the 5-year major adverse cardiovascular events rate, defined as cardiac death, myocardial infarction, or hospitalization due to angina. Results:The mean cTFC was 28.9 ± 6.1 frames per second (median: 28, IQR 24-33; min-max: 19-58). 62 (55.9%) patients had normal coronary flow, and 49 (44.1%) had CSF. Patients did not differ in sex (females no CSF vs. CSF: 58% vs. 61%, p = 0.7) or age (63 ± 15 years vs. 63 ± 13 years, p = 0.8). Patients with CSF characterized higher rates of chronic kidney disease (0 vs. 8.2%, p = 0.035). No statistically significant difference was observed for any of the analysed points. MACE rates for no CSF vs. CSF were 9.6% vs. 14.3% (HR 0.80, 95% CI 0.28-2.96, p = 0.7), respectively.Conclusions: CSF was not associated with a higher risk of adverse events among MINOCA patients at five years.

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Prognostic implication of coronary slow flow assessed by cTFC in patients with myocardial infarction with Non-obstructive coronary arteries

Mareai¹,

Mohammed²,

Zhang³

et al. 2023

European Journal of Internal Medicine

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Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction

Cited by 4 publications

References 40 publications

Effect of hyperhomocysteine in patients after PCI for non-ST-segment elevation myocardial infarction, a retrospective study

Effect of hyperhomocysteine in patients after PCI for non-ST-segment elevation myocardial infarction, a retrospective study

Coronary slow flow is not an adverse prognostic factor in MINOCA patients in the 5-year follow-up

Prognostic implication of coronary slow flow assessed by cTFC in patients with myocardial infarction with Non-obstructive coronary arteries

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