Relationship between platelet count and platelet width distribution and serum uric acid concentrations in patients with untreated essential hypertension

Tayefi, Maryam; Hassanian, Seyed Mahdi; Maftouh, Mona; Moohebati, Mohsen; Bahrami, Afsane; Parizadeh, Seyed Mohammadreza; Mahdizadeh, Adeleh; Ghazizadeh, Hamideh; Bazeli, Javad; Heidari‐Bakavoli, Alireza; Kianifar, Hamidreza; Mohammadzadeh, Elham; Rahmani, Farzad; Esmaeili, Habibollah; Ebrahimi, Mahmoud; Azarpazhooh, Mahmoud Reza; Nematy, Mohsen; Safarian, Mohammad; Avan, Amir; Ghayour‐Mobarhan, Majid

doi:10.1002/biof.1453

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…There is one piece of previous evidence focusing on the independent association between PDW and UA. Tayefi et al showed a significant positive association between PLT and UA in hypertension patients, and PLT and PDW could be independent determinants of high serum UA in newly diagnosed hypertensive patients. But this study had limitations of restricted case number, not focusing on gender differences, and all cases being hypertensive.…”

Section: Discussionmentioning

confidence: 96%

Association between platelet distribution width and serum uric acid in Chinese population

et al. 2019

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Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. This crosssectional study recruited 61,091 ostensible healthy participants (29,259 males and 31,832 females) after implementing exclusion criteria. Clinical data of the enrolled population included anthropometric measurements and serum parameters. Database was sorted by gender, and the association between PDW and hyperuricemia was analyzed after dividing PDW into quartiles. Crude and adjusted odds ratios of PDW for hyperuricemia with 95% confidence intervals were analyzed using binary logistic regression models. We found no significant difference in PDW values between the genders. Males showed significantly higher incidence of hyperuricemia than females. From binary logistic regression models, significant hyperuricemia risks only were demonstrated in PDW quartiles 2 and 3 in males (P < 0.05). This † Xiaoxia Liu and Huiying Wang as co-first authors contributed equally to this article. BioFactors 326Research Communication study displayed close association between PDW and hyperuricemia as a risk factor. It is meaningful to use PDW as a clinical risk predictor for hyperuricemia in males.

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Section: Discussionmentioning

confidence: 96%

Association between platelet distribution width and serum uric acid in Chinese population

et al. 2019

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“…Accordingly, monitoring some inflammatory and/or oxidative stress markers for cardiovascular diseases (CVDs) including high-sensitivity C-reactive protein (hs-CRP), anti-heat-shock protein 27 (anti-hsp27) antibody titer, prooxidant-antioxidant balance (PAB), uric acid, fasting blood glucose (FBG) appears essential due to their important roles in the incidence and development of CVD. [9][10][11] hs-CRP is an acute phase reactant involved in the atherothrombotic process and is considered the strongest univariate predictor of CVDs. 12,13 Hsp27 is an antiapoptotic agent that interferes with oxidative stress and has a role in activating the immune system, extracellularly.…”

Section: Introductionmentioning

confidence: 99%

Age and sex‐specific reference intervals for prooxidant‐antioxidant balance, anti‐heat‐shock protein 27 (anti‐hsp27), and routine laboratory tests in the middle‐aged adult population

Ghazizadeh

Bohn

Yaghooti‐Khorasani

et al. 2021

Biotech and App Biochem

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Introduction:We aimed to define specific reference intervals (RIs) for 11 biomarkers including inflammatory and oxidative stress biomarkers, liver, and renal function tests in a healthy Iranian adult population for the first time. Methods: CLSI Ep28-A3 guidelines were then used to calculate accurate ageand sex-as well as body mass index (BMI)-specific RIs. Results: RIs for studied biomarkers showed no significant age and sex-specific differences, except for uric acid, which had higher concentrations in men when compared to women. Additionally, after partitioning the participants based on the BMI with a cutoff point of 25 kg/m 2 , only the levels of hs-CRP were positively associated with higher BMI (RI for BMI>25: 0.

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“…Another cohort study found that high-sensitivity CRP may serve as a candidate risk predictor for hyperuricemia in middle-aged South Korean men [24], while the association in the older and females has not been reported. However, several studies [22,26] have shown that CRP differ in age and sex. Therefore, the aim of the present cohort study was to explore the longitudinal association between highsensitivity CRP and hyperuricemia in Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Higher Levels of High-Sensitivity C-Reactive Protein Is Positively Associated with the Incidence of Hyperuricemia in Chinese Population: A Report from the China Health and Retirement Longitudinal Study

Zhao

Xia

et al. 2020

Mediators of Inflammation

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Purpose. The aim of the present cohort study was to explore the longitudinal association between high-sensitivity C-reactive protein (CRP) and hyperuricemia in Chinese population. Furthermore, we conducted subgroup analyses to explore this association according to age, sex, and body mass index. Methods. A total of 5,419 healthy participants were enrolled in the final cohort analysis. The high-sensitivity CRP level was measured by immunoturbidimetric assay. Hyperuricemia was defined as serum uric acid ≥7.0 mg/dL (416 μmol/L) in men and ≥6.0 mg/dL (357 μmol/L) in women. Multivariate logistic regression was used to analyze the association. Results. During the 4 years follow-up, 474 participants developed hyperuricemia. Compared with participants in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted odds ratio (OR) (95% confidence interval [CI]) for incident hyperuricemia in the highest tertile was 1.36 (1.02, 1.82). In the subgroup analyses, high-sensitivity CRP was positively associated with the incidence of hyperuricemia after multivariate adjustments (P for trend=0.04) in women. Compared with the women in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted OR (95% CI) in the highest tertile was 1.69 (1.10, 2.66). No statistically significant association was found in other subgroups. Conclusions. The findings of this prospective cohort study suggest that higher level of high-sensitivity CRP is an independent risk factor for hyperuricemia in Chinese, especially in women.

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Relationship between platelet count and platelet width distribution and serum uric acid concentrations in patients with untreated essential hypertension

Abstract: These authors contributed equally to this work.

Cited by 6 publications

References 38 publications

Association between platelet distribution width and serum uric acid in Chinese population

Association between platelet distribution width and serum uric acid in Chinese population

Age and sex‐specific reference intervals for prooxidant‐antioxidant balance, anti‐heat‐shock protein 27 (anti‐hsp27), and routine laboratory tests in the middle‐aged adult population

Higher Levels of High-Sensitivity C-Reactive Protein Is Positively Associated with the Incidence of Hyperuricemia in Chinese Population: A Report from the China Health and Retirement Longitudinal Study

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