Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis

Ji, Shuaifei; Chen, Xuemin; H, Shi; Zhang, Babo; Yao, Shun; Deng, Senlin; Tian, Chunlong; Jiang, Jun; Chen, Fei; Wang, Xiaocheng

doi:10.1042/bsr20181183

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…A meta-analysis investigating the role of platelet parameters found that SSHL patients present with lower platelet counts. 27 In our present work, low-normal platelet count was a significant independent risk factor for the incidence of LFHI during a long-time span of 5 years. In addition, decreasing platelets surprisingly associates with the loss of hearing ability in low-normal platelet group subjects.…”

Section: Discussionsupporting

confidence: 59%

Low‐Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

Abe

Toyama

Kazurayama³

et al. 2020

The Laryngoscope

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Identification of undefined risk factors will be crucial for the development of therapeutic strategies in hearing impairment. Platelets are likely to affect the development of sudden sensorineural hearing loss, which is a primary risk factor for permanent hearing impairment. This implies that abnormal platelets might contribute to long-term hearing loss. This study investigated the role of platelets in the development of hearing impairment over a 5-year period. Methods: This study was a retrospective cohort study and consisted of a population-based survey, which was performed for 1,897 participants in 2014 to 2019. To evaluate the effect of platelet level on hearing ability, the subjects were divided into two groups: a high-normal platelet group (25 40 × 10 4 cells/μL) and a low-normal platelet group (15 25 × 10 4 cells/μL). Subjects were defined as having hearing impairment when pure tone audiometry was over 25 dB HL in either ear (tested in 2017 and 2019). Incidence of hearing impairment was analyzed. Results: Incidence of hearing impairment at low frequencies was significantly higher in the low-normal platelet group than in the high-normal group year over year. Low-normal platelet count associated with low-frequency hearing impairment (LFHI) incidence (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.15-4.76). In the low-normal platelet group, subjects whose counts declined from baseline developed more LFHI than those whose counts increased over time. Further, decreasing platelets appeared to be an independent risk factor contributing to the incidence of LFHI (OR, 2.10; 95%CI, 1.09-4.06) in the low-normal platelet group. Conclusion: Both a low-normal platelet and a declining platelet count were independently associated with the incidence of LFHI.

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Section: Discussionsupporting

confidence: 59%

Low‐Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

Abe

Toyama

Kazurayama³

et al. 2020

The Laryngoscope

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“…In the present study, MPV, PDW and PCT values were significantly higher in Group 1 as compared to Groups 2 and 3, whereas there was no significant difference between Groups 2 and 3 ( Table 1 ). Ji et al [ 26 ] reported a meta-analysis and demonstrated that there was no significant difference among the MPV values and between controls. Sun et al [ 27 ] reported an association between MPV values and poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss

et al. 2020

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BackgroundWe aimed to evaluate the association between mean platelet volume, platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT), and the presence of sudden sensorineural hearing loss (SSNHL) and treatment response. In the literature, there is no study that investigates the platelet functions in diabetic patients with SSNHL.MethodsThe patients were retrospectively assigned into Group 1 (68 diabetic patients with SSNHL), Group 2 (63 nondiabetic patients with SSNHL) and Group 3 (64 healthy controls).ResultsPC was not significantly different between the groups (p > 0.05). MPV, PDW and PCT values were significantly higher in Group 1 as compared to Groups 2 and 3 (p < 0.05). Platelet parameters were not significantly different between the patients who were responsive and nonresponsive to the treatment. Therefore, the platelet parameters did not affect prognosis significantly in this study samples (p > 0.05).ConclusionsThis study showed that platelet parameters did not have a significant effect as a prognostic and predictive value in diabetic and nondiabetic patients with SSNHL. Further studies with more homogenous and larger study groups investigating the platelet parameters are needed to demonstrate microvascular damage and vascular alterations induced by diabetes mellitus.

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“…The initial search yielded 3,747 results, of which 1,936 were duplicates and removed, leaving 1,811 articles for title and abstract review. Of these 1,811 articles, 68 articles were selected for full-text review against the inclusion and exclusion criteria, which yielded 21 articles [6][7][8][9][10][11][12][32][33][34][35][36][37][38][39][40][41][42][43][44][45] (with 54 outcomes) to be used in the final analysis.…”

Section: Searchmentioning

confidence: 99%

Hearing impairment and diverse health outcomes

Trott

Smıth

Xiao

et al. 2021

Wien Klin Wochenschr

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Background: Globally, it is estimated that approximately 1.3 billion people live with some form of hearing impairment. Major causes of hearing loss include infection/disease, age-related factors, and occupational factors. Numerous systematic reviews and meta-analyses have attempted to synthesise literature on these topics. To date there has not been a systematic evaluation of the relationships between hearing impairment and diverse physical, mental, and social outcomes.Objective: We performed an umbrella review of systematic reviews of observational studies with meta analyses for any physical disease, biomarkers of disease, mental health or cognitive outcomes, and/or modifiable risk factors associated with hearing impairment. Methods:For each meta-analytic association, random-effects summary effect size, 95% confidence intervals, heterogeneity, evidence for small-study effect, excess significance bias and 95% prediction intervals were calculated, and risk of bias was assessed via the AMSTAR2 tool. These were used to grade significant evidence (p<0.05) from I to IV, using the recommendations from the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria.Results: From 3,747 studies, 21 were included covering 54 outcomes. Overall, 44/54 outcomes (82%) yielded significant results. Of the highest quality evidence, age related hearing loss and non-specific hearing impairment was negatively associated with several types of cognitive impairments; paediatric bilateral hearing loss was negatively associated with quality of life; sensorineural hearing loss was

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Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis

Cited by 4 publications

References 29 publications

Low‐Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

Low‐Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss

Hearing impairment and diverse health outcomes

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