Relationship between PPARGC1A Gene Polymorphisms with the Increased Risk of Coronary Artery Disease among Patients with Type 2 Diabetes Mellitus in Iran

Saremi, Leila

doi:10.4183/aeb.2015.13

Cited by 4 publications

(9 citation statements)

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“…Recent investigations have indicated that single nucleotide polymorphisms (SNPs) of the PPARGC1A gene may be associated with the susceptibility and progression of NAFLD, obesity, type 2 diabetes mellitus, and hypertension in various ethnicities [9,10]. Previous studies reported an association between PPARGC1A polymorphism at position +1564G/A (rs8192678) with NAFLD, which is associated with the replacement of Gly with Ser (Gly482Ser) [10][11][12]. However, this polymorphism in the Iranian population has not yet been studied and needs to be explored.…”

Section: Introductionmentioning

confidence: 99%

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

Saremi¹,

Lotfıpanah²,

Mohammadi³

et al. 2019

Turk J Med Sci

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Background/aim: Environmental and genetic factors may play a major role in the development of nonalcoholic fatty liver disease (NAFLD) among people with obesity and type 2 diabetes mellitus. Based on the fact that PGC-1α, as the protein encoded by the PPARGC1A gene, plays a key role in energy metabolism pathways, it has been hypothesized that polymorphisms within the PPARGC1A gene may be associated with increased risks of NAFLD. Thus, this study was designed to evaluate the Gly482Ser polymorphism (rs8192678) within the PPARGC1A gene and its association with the increased risk of NAFLD in Iranian patients with type 2 diabetes. Materials and methods:A total of 145 NAFLD patients with a history of type 2 diabetes and 145 healthy control subjects were included in the study. Gly482Ser polymorphism genotyping was done using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) technique. Results:The results showed a significant difference between the PPARGC1A Gly482Ser polymorphism in NAFLD patients and the healthy controls. Accordingly, the AA genotype and A allele were increased in the NAFLD patients when compared to the healthy controls. However, no significant correlation was observed between the Gly482Ser polymorphism and the physiological and biochemical parameters.Conclusion: Based on the results, the AA genotype, which is associated with the insertion of Ser, can be considered as a risk factor for the development of NAFLD in Iranian patients with diabetes type 2.

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Section: Introductionmentioning

confidence: 99%

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

Saremi¹,

Lotfıpanah²,

Mohammadi³

et al. 2019

Turk J Med Sci

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“…Adult diabetic patients have an increased risk of mortality due to heart disease and stroke from 2-4 times more than those without diabetes [22]. Dyslipidemia, obesity, and hypertension are the leading cause of elevating the risk for CVD observed in T2DM patients [1,23]. The identification of genetic markers implicated in dyslipidaemia and oxidative stress, such as the PPARγ gene, is one possible approach to determine an individual risk profile.…”

Section: Discussionmentioning

confidence: 99%

“…Our study included 290 unrelated Iranian subjects with an average age of 52, were consecutively recruited from Shahid Rajaei Cardiovascular Medical and Research Center in Tehran, Iran [1,20]. The patients included 72 men and 73 women with coronary artery disease (CAD) and a history of diabetes.…”

Section: Study Populationmentioning

confidence: 99%

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The common PPARγ2 Pro12Ala polymorphism is associated with an increased risk of coronary artery disease (CAD) in Iranian patients with type 2 diabetes mellitus

Saremi¹,

Lotfıpanah²,

Feizy³

et al. 2020

Preprint

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Background. Type 2 diabetes (T2DM) is a risk factor for coronary artery disease (CAD) in patients with type 2 diabetes compared with subjects without diabetes. Many studies have been shown that CAD has resulted from the interaction of genetic markers implicated in dyslipidaemia and oxidative stress. The PPARγ gene is considered as a potential candidate gene for the link between diabetes mellitus and CAD in patients with diabetes mellitus. The purpose of the present study was to determine the association of Pro12Ala PPARγ2 polymorphism (rs1801282) with CAD in Iranian patients with T2DM.Methods. We studied 290 unrelated Iranian subjects, including 145 healthy controls and 145 CAD patients with a history of T2DM. Genomic DNA was isolated from peripheral blood, and the PPARγ2 gene mutations were analyzed using the PCR–RFLP technique.Results. Our results revealed a significant difference between the allele frequencies of PPARγ2 Pro12Ala polymorphism between the case and control subjects. However, no significant association was observed between Pro12Ala genotypes and physiologic variables.Conclusion. In summary, it could be concluded that PPARγ2 Pro12Ala polymorphism may be an essential indicator of the increased risk of CAD in diabetic patients among the Iranian population.Trial Registration. This article does not contain any studies with human participants by any of the authors.

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“…Among them, the PPAR-γ2 isoform is expressed predominantly in the adipose tissue, where it plays an important role in regulating adipogenic differentiation and as a mediator of insulin sensitivity [ 20 , 22 – 25 ]. The single nucleotide polymorphisms (SNPs) of the PPAR-γ2 gene have been shown to be associated with susceptibility to several metabolic disorders and many studies have shown a strong relationship between this gene and the occurrence of T2DM in many populations [ 9 , 10 , 26 , 27 ]. The polymorphism rs1801282 (c.34C > G) on codon 12 of exon B of the PPAR-γ2 gene, which leads to the substitution of proline with alanine (Pro12Ala), was found to be associated with higher insulin sensitivity, lower body mass index (BMI), decreased risk of T2DM and diabetic nephropathy [ 28 – 32 ].…”

Section: Introductionmentioning

confidence: 99%

The Pro12Ala polymorphism in the PPARγ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus

et al. 2019

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BackgroundThe peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Several studies have demonstrated a significant association between Pro12Ala polymorphism of the PPARγ2 gene and metabolic disorders. Therefore, this study aimed to evaluate the association of Pro12Ala polymorphism with increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus.MethodsThis cross-sectional study was performed on 145 healthy control subjects and 145 NAFLD patients with a history of type 2 diabetes. Pro12Ala polymorphism genotyping was performed using PCR–restriction fragment length polymorphism (RFLP) technique with the Bs1I restriction enzyme.ResultsOur results demonstrated that CC and GG genotypes of Pro12Ala were found in the participants, but there was no statistically significant difference between NAFLD patients and healthy controls (P = 0.64 and χ2 = 0.21).ConclusionThis study suggests that Pro12Ala polymorphism of the PPARγ2 gene cannot be considered as a risk factor for NAFLD in the Iranian population.

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Relationship between PPARGC1A Gene Polymorphisms with the Increased Risk of Coronary Artery Disease among Patients with Type 2 Diabetes Mellitus in Iran

Cited by 4 publications

References 0 publications

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

The common PPARγ2 Pro12Ala polymorphism is associated with an increased risk of coronary artery disease (CAD) in Iranian patients with type 2 diabetes mellitus

The Pro12Ala polymorphism in the PPARγ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus

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Relationship between PPARGC1A Gene Polymorphisms with the Increased Risk of Coronary Artery Disease among Patients with Type 2 Diabetes Mellitus in Iran

Cited by 4 publications

References 0 publications

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus

The common PPARγ2 Pro12Ala polymorphism is associated with an increased risk of coronary artery disease (CAD) in Iranian patients with type 2 diabetes mellitus

The Pro12Ala polymorphism in the PPAR­γ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus

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The Pro12Ala polymorphism in the PPARγ2 gene is not associated with an increased risk of NAFLD in Iranian patients with type 2 diabetes mellitus