Relationship Between Pre-operative Blood Glucose Level and Length of Hospital Stay in Patients With Renal Cell Carcinoma Undergoing Laparoscopic Nephrectomy

He, Ting; Zhu, Weidong; Wang, Qianqian; Lü, Hongmei; Wu, Tiange; Pan, Ke-Hao; Chen, Shuqiu; Xu, Bin; Mao, Weipu; Li, Wei; Chen, Ming

doi:10.3389/fsurg.2021.659365

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Sun et al 25 also found that a higher POBG level was significantly associated with longer LOS, by analyzing data of 310 patients with kidney stones who underwent percutaneous nephrolithotomy. He et al 16 investigated the relationship between POBG and LOS in 338 patients with renal cell carcinoma, who underwent laparoscopic nephrectomy, and found that POBG was positively associated with the risk of LOS greater than or equal to 2 weeks and LOS greater than or equal to 3 weeks. These studies collectively indicate that hyperglycemia increases LOS in hospitalized patients, which may be because hyperglycemia increases the risk of surgical site infection, prolongs wound healing time, and thus increases the LOS in the hospital 26,27 .…”

Section: Discussionmentioning

confidence: 99%

“…The restricted cubic spline (RCS) function allows a more intuitive description of the dose–response relationship between continuous variables and outcomes 16 . Dose–response analysis curves using the RCS function were used to confirm the relationship between blood glucose levels and LOS greater than or equal to 2 days, LOS greater than or equal to 5 days, and LOS greater than or equal to 7 days.…”

Section: Methodsmentioning

confidence: 99%

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Relationship between blood glucose levels and length of hospital stay in patients with acute pancreatitis: An analysis of MIMIC‐III database

Wang

Zhang

et al. 2022

Clinical Translational Sci

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We aimed to investigate the effect of blood glucose levels on length of stay (LOS) in patients hospitalized with acute pancreatitis (AP). We retrospectively collected clinical data of patients diagnosed with AP from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Dose-response analysis curves of restricted cubic spline (RCS) function and multivariate logistic regression models were used to confirm the relationship between blood glucose levels and LOS.A total of 3656 patients with AP were included according to the inclusion and exclusion criteria. According to RCS, all patients were divided into three groups, namely the less than 68 mg/dl group, the 68-104 mg/dl group, and the >104 mg/ dl group. RCS showed a significant nonlinear correlation between blood glucose levels and LOS (p < 0.001). Multivariate logistic regression revealed a 53% higher risk of LOS greater than or equal to 2 days (adjusted odds ratio [aOR] = 1.53, 95% confidence interval [CI] 1.24-1.89, p < 0.001), a 114% higher risk of LOS greater than or equal to 5 days (aOR = 2.14, 95% CI 1.86-2.47, p < 0.001), and a 130% higher risk of LOS greater than or equal to 7 days (aOR = 2.30, 95% CI 1.97-2.69, p < 0.001) in patients with glucose levels greater than 104 mg/dl than patients with glucose levels 68-104 mg/dl. The risk of LOS greater than or equal to 7 days was higher in patients with blood glucose less than 68 mg/dl than patients with glucose levels 68-104 mg/dl (aOR = 1.45, 95% CI 1.02-2.05, p = 0.040). In addition, we observed similar results in many subgroups. Our findings suggest that either hyperglycemia or hypoglycemia increase LOS in patients hospitalized with AP. For hospitalized patients with AP, blood glucose control in a reasonable range of 68-104 mg/dl is required. Study Highlights WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC?Acute pancreatitis (AP) is a common emergency of the digestive system, and the number of hospitalizations due to AP is increasing every year, leading to an

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Relationship between blood glucose levels and length of hospital stay in patients with acute pancreatitis: An analysis of MIMIC‐III database

Wang

Zhang

et al. 2022

Clinical Translational Sci

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“…The results of a single-center retrospective study demonstrated that diabetes was a predictor of recurrence after surgery for non-metastatic renal cell carcinoma, especially in obese patients ( 24 ). He et al found that higher preoperative blood glucose levels were associated with prolonged patient length of stay by collecting clinical data from 338 RCC patients undergoing laparoscopic nephrectomy ( 25 ). In patients with metastatic renal cell carcinoma (mRCC), CSS and OS were significantly shorter in preoperative diabetic patients than in non-diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of glucose to lymphocyte ratio for patients with renal cell carcinoma undergoing laparoscopic nephrectomy: A multi-institutional, propensity score matching cohort study

Li²,

Song³

et al. 2022

Front. Surg.

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BackgroundWe evaluated the prognostic value of preoperative blood glucose to lymphocyte ratio (GLR) in renal cell carcinoma (RCC) patients who underwent laparoscopic nephrectomy through a multi-institutional clinical study.MethodsA total of 420 patients with RCC from three medical centers from 2014 to 2019 were included in this study. The effect of GLR on overall survival (OS) and cancer-specific survival (CSS) in RCC patients was assessed by Kaplan-Meier survival curves, univariate and multivariate Cox regression analysis. Moreover, a 1:1 propensity score matching (PSM) analysis of different GLR groups was utilized to further confirm the prognostic ability of GLR.ResultsThe optimal cut-off value for GLR was 6.8. Patients were divided into high GLR and low GLR groups according to the optimal cut-off value. GLR was significant association with diabetes, cardiovascular disease and AJCC stage. High GLR predicted adverse OS (P = 0.002) and CSS (P < 0.01) in RCC patients. Multivariate Cox regression analysis revealed that high GLR was an independent prognostic factor for OS [hazard ratio (HR): 2.389, 95% confidence interval (CI), 1.136–5.027, P = 0.008] and CSS (HR: 3.474, 95% CI, 1.555–7.761, P = 0.002). After PSM analysis of the patients in the high GLR and low GLR groups, high GLR still predicted poor OS (P = 0.021) and CSS (P = 0.037).ConclusionsHigh GLR is associated with adverse prognosis in RCC patients, and GLR can serve as an independent prognostic marker for OS and CSS in RCC patients receiving laparoscopic nephrectomy.

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“…The studies involving human participants were reviewed and approved by Ethics Committee and Institutional Review Board for Clinical Research of Zhongda Hospital (ZDKYSB077) ( 43 , 44 , 45 , 46 ). This study is a retrospective study that only collected clinical data from patients, and the ethical committee approved the exemption of informed consent.…”

Section: Ethics Statementmentioning

confidence: 99%

ASNS can predict the poor prognosis of clear cell renal cell carcinoma

Gan

Liu²,

Cheng³

et al. 2022

Front. Oncol.

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PurposeClear cell renal cell carcinoma (ccRCC) is one of the most common malignancies of the urinary system. This study was conducted to discover a new target that can predict the prognosis and promote the treatment of ccRCC.MethodsThe raw data were downloaded from the TCGA database, and the predictive value of ASNS for various clinicopathological features was verified in the following analysis. Then, we analyzed the potential involvement of ASNS in tumor immunity and obtained the possible pathways involving ASNS through GO/KEGG enrichment analysis and GSEA. We also further verified our findings in pathological specimens of ccRCC patients.ResultsASNS expression was significantly increased in ccRCC, which was associated with advanced clinicopathological characteristics. It was an independent prognostic factor for overall survival in 535 patients with ccRCC. Immune cell infiltration analysis revealed that ASNS expression was related to T lymphocyte infiltration of tumors and poor prognosis. Moreover, we performed relevant functional enrichment analyses of ASNS.ConclusionsASNS might play a significant role in the development and immune cell infiltration of ccRCC and serve as a valuable clinical prognostic biomarker.

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Relationship Between Pre-operative Blood Glucose Level and Length of Hospital Stay in Patients With Renal Cell Carcinoma Undergoing Laparoscopic Nephrectomy

Cited by 5 publications

References 23 publications

Relationship between blood glucose levels and length of hospital stay in patients with acute pancreatitis: An analysis of MIMIC‐III database

Relationship between blood glucose levels and length of hospital stay in patients with acute pancreatitis: An analysis of MIMIC‐III database

Prognostic value of glucose to lymphocyte ratio for patients with renal cell carcinoma undergoing laparoscopic nephrectomy: A multi-institutional, propensity score matching cohort study

ASNS can predict the poor prognosis of clear cell renal cell carcinoma

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