Relationship Between Preoperative Comorbidity, Systemic Inflammatory Response, and Survival in Patients Undergoing Curative Resection for Colorectal Cancer

Abstract

Comorbidity does not fully explain the relationship between the mGPS and cancer-specific survival in CRC patients. Furthermore, comorbidity, in particular that measured by the LCRI, is an important independent indicator of cancer survival.

Colorectal Cancer, Systemic Inflammation, and Outcome

“…However, the common chronic inflammatory conditions, such as rheumatoid arthritis, do not normally preclude adjuvant chemotherapy. It is therefore of interest that an elevated mGPS has previously been associated with co-morbid status 12,13 and the presence of post-operative infectious complications. 14 However, although both may preclude use of adjuvant chemotherapy and explain the present inverse association between mGPS and use of adjuvant therapy, 15 it is important to note that the relationship between mGPS and oncological outcome has previously been shown to be independent of underlying patient co-morbidity.…”

“…14 However, although both may preclude use of adjuvant chemotherapy and explain the present inverse association between mGPS and use of adjuvant therapy, 15 it is important to note that the relationship between mGPS and oncological outcome has previously been shown to be independent of underlying patient co-morbidity. 13,16 Of interest, the mGPS stratified the survival of patients who received adjuvant chemotherapy following resection of stage III colon cancer. Although the present analysis must be interpreted with caution, it is consistent with previous reports.…”

Modified glasgow prognostic score in patients with small-cell lung cancer

“…This prognostic score is now believed to reflect the condition of cachexia in malignant disease. In various cancer types such as gastrointestinal cancer, it is evaluated as an independent prognostic factor (11,12). Its clinical significance has been also evaluated in NSCLC (13,14), but has scarcely evaluated in patients with SCLC (8).…”

Impact of Chronic Kidney Disease on Outcomes of Surgical Resection for Primary Colorectal Cancer

“…[7][8][9] A greater likelihood of various comorbidities including CKD in CRC patients was reported recently. 10 Moreover, both CKD and CRC are more frequent in elderly than younger populations [1][2][3]11 ; nonetheless, there is still a lack of detailed data on the impact of CKD in the treatment of CRC.…”