Relationship between preoperative lymphocyte to monocyte ratio and surgery outcome in type A aortic dissection

Abstract

BackgroundLymphocyte-to-monocyte ratio (LMR) is associated with the mortality of cardiovascular diseases. However, the relationship between preoperative LMR and the prognosis of patients with Stanford type A aortic dissection (TAAD) undergoing surgical treatment remains to be determined.MethodsWe enrolled 879 patients with TAAD undergoing surgical treatment between January 2018 and December 2021. Patients were divided into two groups: the Deceased group and the Survived group. The baseline clinical and operative characteristics of the two groups were compared and analyzed.ResultsIn univariate and multivariate logistic regression analysis, the association between LMR and in-hospital mortality was significant, and LMR (OR = 1.598, 95% CI 1.114–2.485, P = 0.022) remained significant after adjusting for confounders.ConclusionLower LMR may be independently associated with higher in-hospital mortality in TAAD undergoing surgical treatment.

The Preoperative Lymphocyte-To-Monocyte Ratio Predicts Mortality Among Patients Undergoing Endovascular Aortic Repair for Abdominal Aortic Aneurysm

“…There are several prognostic biomarkers from peripheral blood components, such as NLR, platelet-to-lymphocyte ratio (PLR), monocyte-to-high-density lipoprotein cholesterol ratio, and LMR. 6 The LMR, which is calculated as a ratio of lymphocytes to monocytes, has been increasingly recognized as a newly emerging inflammatory biomarker in 17 The LMR has also been studied as a prognostic indicator for adverse outcomes in cardiovascular disorders, including acute coronary syndrome, 7 acute myocardial infarction, 8 acute aortic dissection, 10,11 and peripheral artery disease. 12 The prognostic value of LMR in AAA patients undergoing EVAR remains to be elucidated.…”

“…6 The LMR, which is calculated as a ratio of lymphocytes to monocytes, has been increasingly recognized as a newly emerging inflammatory biomarker in clinical practice; it has been identified as a poor prognostic indicator in various cancers, independent of cancer type and stage, treatment, age, performance status. 17 The LMR has also been studied as a prognostic indicator for adverse outcomes in cardiovascular disorders, including acute coronary syndrome, 7 acute myocardial infarction, 8 acute aortic dissection, 10,11 and peripheral artery disease. 12…”

“…Likewise, lymphocytopenia is associated with overall mortality risk independently of traditional risk factors. 5 More recently, it has been reported that the lymphocyteto-monocyte ratio (LMR), a newly emerging inflammatory index, may have a potential value in predicting the prognosis of not only various malignancies 6 but also atherosclerotic cardiovascular diseases [7][8][9][10][11][12] ; both lymphocytes and monocytes and/or macrophages play an important role in the pathophysiology of atherosclerosis. 13 These studies suggest that the LMR can be a useful tool in discriminating between higher-risk and low-risk patients with atherosclerotic cardiovascular diseases.…”