Relationship between primary lesion metabolic parameters and clinical stage in lung cancer

Şahiner, Ilgın; Atasever, Tamer; Akdemir, Ümit Özgür; Öztürk, Can; Memış, Leyla

doi:10.1016/j.remn.2013.03.008

Cited by 8 publications

(7 citation statements)

References 33 publications

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“…[15] Similarly, our study revealed that SUVmax of the primary carcinoid tumor has a positive correlation with the tumor diameter for 22 patients. It was reported that FDG uptake correlates well with Glut-1 expression.…”

Section: Discussionsupporting

confidence: 66%

18F-FDG PET/CT rarely provides additional information other than primary tumor detection in patients with pulmonary carcinoid tumors

Tatci¹,

Özmen²,

Gökçek³

et al. 2014

Ann Thorac Med

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AIM:The purpose of this study was to assess the contribution of 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) in detection and staging of pulmonary carcinoid tumors.METHODS:A total of 22 patients with pulmonary carcinoid tumors (14 typical, 8 atypical) were reviewed in this retrospective study. PET/CT images of all patients were evaluated for primary tumor as well as metastatic regional lymph nodes, bone and other distant metastases. PET/CT positivity of primary tumors was determined by visual interpretation. Tumor size, SUVmax and Hounsfield Unit (HU) values of the tumors were used to test for differences between tumor groups (typical carcinoids and atypical carcinoids).RESULTS:SUVmax of carcinoids ranged from 1.24 to 11.1 (mean, 5.0; median, 2.67). The mean largest diameter of primary tumors was 2.7 ± 1.3 cm, ranging from 1 to 5.5 cm. The overall sensitivity of FDG PET/CT for detection of pulmonary carcinoid tumors was 81.8%. Tumor size, SUVmax and Hounsfield Unit (HU) values of the atypical carcinoids were higher than those for typical carcinoids. However, the results were not statistically meaningful (P > 0.05). The sensitivity and specificity of FDG PET/CT in the detection of mediastinal and hilar lymph nodes metastases were 25% and 83% respectively. One patient had bone metastasis.CONCLUSION:Although FDG PET/CT can be a useful tool for the detection of pulmonary carcinoid tumors and distant metastasis, it cannot discriminate typical carcinoids from atypical ones and absence of an FDG avid lesion cannot exclude pulmonary carcinoid tumors. Moreover, PET/CT is not a reliable tool in the staging of mediastinal and hilar lymph nodes especially for those patients with typical carcinoids.

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Section: Discussionsupporting

confidence: 66%

18F-FDG PET/CT rarely provides additional information other than primary tumor detection in patients with pulmonary carcinoid tumors

Tatci¹,

Özmen²,

Gökçek³

et al. 2014

Ann Thorac Med

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“…Additional studies must be performed with larger numbers of patients to settle this issue. We also found no correlation between the SUVmax and SUVmean with the AJCC stage and pT or pN stage or a statistically significant difference in the mean values, although these relationships have been reported in NSCLC 43 and other tumors. 23 One of the most important advantages of texture analysis is that its measurement is performed in the postprocessing PET/CT image.…”

Section: Heterogeneity In Pet/ct Imaging Of Lung Carcinomacontrasting

confidence: 74%

Heterogeneity in [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of Non–Small Cell Lung Carcinoma and Its Relationship to Metabolic Parameters and Pathologic Staging

et al. 2014

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To investigate the relationships between tumor heterogeneity, assessed by texture analysis of [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) images, metabolic parameters, and pathologic staging in patients with non-small cell lung carcinoma (NSCLC). A retrospective analysis of 38 patients with histologically confirmed NSCLC who underwent staging FDG-PET/computed tomography was performed. Tumor images were segmented using a standardized uptake value (SUV) cutoff of 2.5. Five textural features, related to the heterogeneity of gray-level distribution, were computed (energy, entropy, contrast, homogeneity, and correlation). Additionally, metabolic parameters such as SUVmax, SUVmean, metabolic tumor volume (MTV), and total lesion glycolysis (TLG), as well as pathologic staging, histologic subtype, and tumor diameter, were obtained. Finally, a correlation analysis was carried out. Of 38 tumors, 63.2% were epidermoid and 36.8% were adenocarcinomas. The mean ± standard deviation values of MTV and TLG were 30.47 ± 25.17 mL and 197.81 ± 251.11 g, respectively. There was a positive relationship of all metabolic parameters (SUVmax, SUVmean, MTV, and TLG) with entropy, correlation, and homogeneity and a negative relationship with energy and contrast. The T component of the pathologic TNM staging (pT) was similarly correlated with these textural parameters. Textural features associated with tumor heterogeneity were shown to be related to global metabolic parameters and pathologic staging.

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“…Certain studies have demonstrated that SUV max is an independent predictor of stage and a determinant of survival in patients with OC [8,19]. However, in our study, we did not observe a relationship between histological subtypes in terms of TLG and SUV max .…”

Section: Discussioncontrasting

confidence: 99%

“…Although the first and most commonly used PET parameter is SUV max , an increasing number of studies highlight the prognostic value of other metabolic parameters such as MTV and TLG for oesophageal carcinomas [8,9]. In our study, we found that only the MTV of the primary tumour and whole body was associated the histological subtype and MTV values of OAC significantly higher than OSCC (cut-off value > 26.89 for both primary tumour MTV and total MTV; detailed sensitivity, specificity, PPV, NPV, and accuracy data are given in Table 4 and Figure 3).…”

Section: Discussionmentioning

confidence: 99%

The relationship between FDG PET/CT-defined metabolic parameters and the histopathological subtype of oesophageal carcinomas

et al. 2020

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Purpose: 18F-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET) combined with computed tomography (CT) scan is accepted as a standard tool in the staging of oesophageal cancer (OC). Histological subtype of tumour is known to be a major determinant of prognosis and metabolic behaviour. In this study, we aimed to evaluate the effect of histological subtypes of OC on standard uptake value (SUV max), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) obtained by PET/CT, and also to compare this effect with prognosis. Material and methods: Images and clinical course data of 57 patients who were diagnosed with EC and treated in our hospital between 2009 and 2016 were evaluated in a retrospective manner. PET/CT images were re-analysed in terms of metabolic parameters, and observations were compared with histological subtypes. Results: No significant difference was observed between histological subtypes with SUV max , overall survival (OS), or progression-free survival (PFS). Thus, MTV was observed to be related with histological subtype; MTV values of adenocancer patients were significantly higher than those of squamous cell cancer patients. Conclusions: Metabolic tumour volume was related with histological subtype of OC, but clinical staging, TLG, and SUV max values were not related with histological subtype, which may suggest the use of MTV as a routine parameter for OC and inclusion of MTV observations in prognostic scoring.

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Relationship between primary lesion metabolic parameters and clinical stage in lung cancer

Cited by 8 publications

References 33 publications

18F-FDG PET/CT rarely provides additional information other than primary tumor detection in patients with pulmonary carcinoid tumors

18F-FDG PET/CT rarely provides additional information other than primary tumor detection in patients with pulmonary carcinoid tumors

Heterogeneity in [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of Non–Small Cell Lung Carcinoma and Its Relationship to Metabolic Parameters and Pathologic Staging

The relationship between FDG PET/CT-defined metabolic parameters and the histopathological subtype of oesophageal carcinomas

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Relationship between primary lesion metabolic parameters and clinical stage in lung cancer

Cited by 8 publications

References 33 publications

18F-FDG PET/CT rarely provides additional information other than primary tumor detection in patients with pulmonary carcinoid tumors

18F-FDG PET/CT rarely provides additional information other than primary tumor detection in patients with pulmonary carcinoid tumors

Heterogeneity in [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of Non–Small Cell Lung Carcinoma and Its Relationship to Metabolic Parameters and Pathologic Staging

The relationship between FDG PET/CT-defined metabolic parameters and the histopathological subtype of oesophageal carcinomas

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Heterogeneity in [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of Non–Small Cell Lung Carcinoma and Its Relationship to Metabolic Parameters and Pathologic Staging