Relationship between procalcitonin plasma levels and severity of injury, sepsis, organ failure, and mortality in injured patients

Wanner, Guido A.; Keel, Marius; Steckholzer, Ursula; W, Beier; Stocker, Reto; Ertel, Wolfgang

doi:10.1097/00003246-200004000-00007

Cited by 243 publications

(185 citation statements)

References 23 publications

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“…In local and systemic inflammation, successive monocytic activation is a prerequisite for PCT production (21)(22)(23)(24). PCT serves as a chemo-attractant.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

EAJEM

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“…In local and systemic inflammation, successive monocytic activation is a prerequisite for PCT production (21)(22)(23)(24). PCT serves as a chemo-attractant.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

EAJEM

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“…PCT seems to be a good marker for monitoring the status of inflammatory reaction in patients suffering from multiple trauma [12], although significant gender differences between men and women have been found [13]. Experiments have shown that hepatic tissue stimulated by TNF-alpha or Table 2.…”

Section: Discussionmentioning

confidence: 99%

“…Peak values are observed in the first 24 hours and around the 3 rd day following trauma. High levels of PCT during the first days after injury are believed to be a prognostic factor in severe systemic inflammatory response syndrome (SIRS), infection or multiple organ dysfunction syndrome (MODS) [12][13][14][15][16].…”

mentioning

confidence: 99%

Changes of procalcitonin level in multiple trauma patients

Wojtaszek¹,

Staśkiewicz²,

Torres³

et al. 2014

Anaesthesiol Intensive Ther

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Background: Some aspects of the pathophysiology of complications in multiple-trauma patients still remain unclear. Mediators of inflammation have been postulated as playing a key role in being responsible for life threatening complications of multiple trauma patients. The objective of this study was to evaluate the prognostic value of procalcitonin (PCT) level in multiple trauma patients. Methods: A prospective study took place including patients with multiple trauma hospitalised in several hospital units. PCT level was measured in blood from 45 patients, aged 18-70 years using enzyme-linked immunoassay. The patients were divided into three groups: group I -individuals with multiple trauma with central nervous system injury; group II -those with multiple trauma without CNS injury; and group III -patients with isolated central nervous system injury. Results: Initial PCT levels were below 0.5 ng mL -1 regardless of the cause of trauma. In the 24 th hour of observation, a statistically significant increase of PCT concentration vs. initial levels was recorded in all groups of patients. Then PCT levels decreased significantly at the 3 rd measurement point in all groups, and they remained unchanged until the last measurement. The highest levels of PCT were observed in multiple trauma patients without CNS injury (group II). In this group of patients, a significantly longer duration of surgery in the post-trauma period affected PCT levels. PCT concentrations in patients who died were significantly greater than in survivors. Conclusions: A long lasting elevated concentration of procalcitonin in the post-traumatic period, or its repeated increase, is a good marker of developing complications observed earlier than clinical manifestations.

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“…Further, ICU length of stay is affected by other variables that may not be reflected in the chart, such as communication and family issues, stress and depression, palliative care and ethical issues, 24-hour presence of a physician, and availability of a unit-specific social worker. 7 Use of the SIRS score in this research is supported by (1) the outcomes of the 2001 consensus conference, 16 (2) research that correlates the presence of SIRS with inflammatory biomarkers, [32][33][34][35] and (3) research that validates its use for predicting outcomes in critically ill patients, including those with acute, life-threatening injuries.…”

Section: Limitationsmentioning

confidence: 92%