Relationship between Prostate Specific Antigen, Prostate Volume and Age in the Benign Prostate

Collins, Gerald N.; Lee, R. J.; McKELVIE, G. B.; Rogers, A. C. N.; Hehir, M.

doi:10.1111/j.1464-410x.1993.tb15990.x

Cited by 168 publications

(94 citation statements)

References 25 publications

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“…Similarly, although PSA values rise as part of the natural history in benign as well as malignant prostatic disease, this has only been reported in patients with the prostate in-situ. For example, patients with benign prostatic hyperplasia typically have a PSA rise of 0.2 ng ml -1 year -1 (Collins et al, 1993). It is not necessarily the case that residual benign prostatic tissue after RRP will have the similar PSA kinetics.…”

Section: Discussionmentioning

confidence: 99%

Undetectable ultrasensitive PSA after radical prostatectomy for prostate cancer predicts relapse-free survival

et al. 2000

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Radical retropubic prostatectomy is considered by many centres to be the treatment of choice for men aged less than 70 years with localized prostate cancer. A rise in serum prostate-specific antigen after radical prostatectomy occurs in 10-40% of cases. This study evaluates the usefulness of novel ultrasensitive PSA assays in the early detection of biochemical relapse. 200 patients of mean age 61. 2 years underwent radical retropubic prostatectomy. Levels < or = 0.01 ng ml-1 were considered undetectable. Mean pre-operative prostate-specific antigen was 13.3 ng ml-1. Biochemical relapse was defined as 3 consecutive rises. The 2-year biochemical disease-free survival for the 134 patients with evaluable prostate-specific antigen nadir data was 61.1% (95% CI: 51.6-70.6%). Only 2 patients with an undetectable prostate-specific antigen after radical retropubic prostatectomy biochemically relapsed (3%), compared to 47 relapses out of 61 patients (75%) who did not reach this level. Cox multivariate analysis confirms prostate-specific antigen nadir < or = 0.01 ng ml-1 to be a superb independent variable predicting a favourable biochemical disease-free survival (P < 0.0001). Early diagnosis of biochemical relapse is feasible with sensitive prostate-specific antigen assays. These assays more accurately measure the prostate-specific antigen nadir, which is an excellent predictor of biochemical disease-free survival. Thus, sensitive prostate-specific antigen assays offer accurate prognostic information and expedite decision-making regarding the use of salvage prostate-bed radiotherapy or hormone therapy

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Section: Discussionmentioning

confidence: 99%

Undetectable ultrasensitive PSA after radical prostatectomy for prostate cancer predicts relapse-free survival

et al. 2000

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“…PSA is mainly synthesised in and secreted from epithelium of prostate tissue, and it correlates positively with age and prostate volume (1).…”

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confidence: 99%

Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men

Pizent

Čolak²,

Kljaković

et al. 2009

Archives of Industrial Hygiene and Toxicology

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The combined infl uence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on prostate-specifi c antigen (PSA) in serum was investigated in a group of 57 men aged 21 years to 40 years. The subjects had no occupational exposure to metals and no other known reasons suspected of infl uencing prostate function or metal metabolism. No signifi cant correlation was found between PSA and any of the explanatory variables considered. Nevertheless, when taking into account all of the above-mentioned potentially explanatory variables, the results of stepwise multiple regression showed a signifi cant increase in PSA with respect to an increase in blood lead, and a decrease in PSA with respect to an increase in intensity of alcohol consumption. The median and range values of blood lead concentration in the 57 men were 26.0 µg L -1 and (10.1 to 108.0) µg L -1 , respectively. These results suggest that even a low-level environmental lead exposure, common for general populations worldwide, may contribute to the risk of prostate cancer in men. The infl uence of lead as well as cadmium, zinc, and selenium on prostate damage and PSA should be further investigated in relatively young men for the purpose of disease prevention.

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“…[16][17][18] In the present study, there were significant differences in PSA between the groups except for group Mo versus Ma (P = 0.079).…”

Section: Discussionmentioning

confidence: 66%

Does digital rectal examination predict prostate volume greater than 30 mL?

2017

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Abbreviations & Acronyms BPH = benign prostatic hyperplasia DRE = digital rectal examination F = flat LUTS = lower urinary tract symptoms LUTS/BPH = lower urinary tract symptoms suggestive of benign prostatic hyperplasia Ma = markedly enlarged Mo = moderately enlarged N = normal PV = prostate volume S = slightly enlarged TRUS = transrectal ultrasound Objectives: To investigate the accuracy of digital rectal examination in estimating prostate volume in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Methods: A community-based study was carried out in Japan to investigate the prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia. A total of 457 men were screened and deemed eligible for the present analysis. Findings on digital rectal examination were compared with prostate volume measurement by transrectal ultrasound. Five groups were identified on digital rectal examination: flat, normal, slightly enlarged, moderately enlarged and markedly enlarged. Results: The median age and prostate volume were 64 years and 19.7 mL, respectively. Prostate volumes for the flat, normal, slightly enlarged, moderately enlarged, and markedly enlarged groups were 16.4, 18.3, 27.0, 41.9 and 86.3 mL, respectively. There were significant differences in prostate volume between the groups. The positive predictive value was 94.1% if flat, and normal were assumed to have a prostate volume <30 mL. The value was 80.8% if moderately enlarged, and markedly enlarged were assumed to have a prostate volume ≥30 mL. Of the men in the slightly enlarged group, 61.0% had a prostate volume <30 mL. Conclusions: It is possible to stratify prostate volume according to digital rectal examination. We could determine the prostates in the flat and normal groups to have a prostate volume <30 mL, and those in the moderately enlarged and markedly enlarged groups to have a prostate volume ≥30 mL by digital rectal examination with high accuracy. Transrectal ultrasound was required for those in the slightly enlarged group.

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Relationship between Prostate Specific Antigen, Prostate Volume and Age in the Benign Prostate

Cited by 168 publications

References 25 publications

Undetectable ultrasensitive PSA after radical prostatectomy for prostate cancer predicts relapse-free survival

Undetectable ultrasensitive PSA after radical prostatectomy for prostate cancer predicts relapse-free survival

Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men

Does digital rectal examination predict prostate volume greater than 30 mL?

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