Relationship between protein arginine methyltransferase and cardiovascular disease (Review)

Zheng, Sisi; Zeng, Congcong; Huang, Ailing; Huang, Fuqi; Meng, Anna; Wu, Zhuan; Zhou, Shanshan

doi:10.3892/br.2022.1572

Cited by 8 publications

(4 citation statements)

References 71 publications

(114 reference statements)

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“…PRMT1 expression is elevated in certain conditions, such as cancer, and in several tissues, such as blood vessels, and it plays an important role in immunity and cardiovascular disease. 80 Therefore, this diet-modifiable CpG might be an interesting target as it lies on the pathway between diet quality and various cardiometabolic traits. Nonetheless, MR evidence also supports causal associations between three CpGs and cardiometabolic traits in which better diet quality DNAm levels were associated with worse cardiometabolic health markers, which were opposite to what was found in observational EWAS, in particular for cg23761815 (SLC29A3) and cg02650017 ( PHOSPHO1 ) in relation to T2D risk.…”

Section: Discussionmentioning

confidence: 99%

Blood DNA methylation signature of diet quality and association with cardiometabolic traits

Domínguez-Barragán,

Fernández-Sanlés,

Hernáez

et al. 2023

European Journal of Preventive Cardiology

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Background Diet quality might influence cardiometabolic health through epigenetic changes, but this has been little investigated in adults. Our aim was to identify Cytosine-phosphate-Guanine (CpG) dinucleotides associated with diet quality by conducting an epigenome-wide association study (EWAS) based on blood DNA methylation (DNAm), and to assess how diet-related CpGs associate with inherited susceptibility to cardiometabolic traits: body mass index (BMI), systolic blood pressure (SBP), triglycerides, type 2 diabetes (T2D) and coronary heart disease (CHD). Methods Meta-EWAS including 5,274 participants in four cohorts from Spain, the US and the UK. We derived three dietary scores (exposures) to measure adherence to a Mediterranean diet (MMDS), to a healthy plant-based diet (HPDI) and to the Dietary Approaches to Stop Hypertension (DASH). Blood DNAm (outcome) was assessed with the Infinium arrays Human Methylation 450 K BeadChip and MethylationEPIC BeadChip. For each diet score, we performed linear EWAS adjusted for age, sex, blood cells, smoking and technical variables, and BMI in a second set of models. We also conducted Mendelian randomization analyses to assess the potential causal relationship between diet-related CpGs and cardiometabolic traits. Results We found 18 differentially methylated CpGs associated with dietary scores (p-value < 1.08 × 10-7; Bonferroni correction), of which 12 were previously associated with cardiometabolic traits. Enrichment analysis revealed overrepresentation of diet-associated genes in pathways involved in inflammation and cardiovascular disease. Mendelian randomization analyses suggested that genetically determined methylation levels corresponding to lower diet quality at cg02079413 (SNORA54), cg02107842 (MAST4), and cg23761815 (SLC29A3) were causally associated with higher BMI, and at cg05399785 (WDR8) with greater SBP; and methylation levels associated with higher diet quality at cg00711496 (PRMT1) with lower BMI, T2D risk and CHD risk, and at cg0557921 (AHRR) with lower CHD risk. Conclusions Diet quality in adults was related to differential methylation in blood at 18 CpGs, some of which related to cardiometabolic health. Availability: The R code for the analysis is available in the following Github repository: https://github.com/jorgedb98/B64_DIAMETR.git

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Section: Discussionmentioning

confidence: 99%

Blood DNA methylation signature of diet quality and association with cardiometabolic traits

Domínguez-Barragán,

Fernández-Sanlés,

Hernáez

et al. 2023

European Journal of Preventive Cardiology

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“…Obesity increases the burden on the heart and leads to abnormal cardiovascular function. PRMT1 regulates vascular function and blood circulation in the cardiovascular system and can modify and regulate a series of proteins related to vasoconstriction, relaxation and vascular endothelial function 58,59 . Calmodulin‐dependent protein kinase II (CaMKII) disorder is strongly associated with myocardial hypertrophy and heart failure, and PRMT1 is essential for preventing the overactivation of CaMKII in the heart.…”

Section: Regulatory Effects Of Protein Arginine Methyltransferase 1 O...mentioning

confidence: 99%

“…PRMT1 inhibits myocardial hypertrophy by inhibiting CaMKII. Meanwhile, the regulation of cardiac I Ks activity mediated by PRMT1 may be a key target for preventing excessive prolongation of the disease course and arrhythmia in patients with heart failure 58 . In summary, PRMT1 plays an important regulatory role in the cardiovascular system and can regulate the function of the heart and blood vessels through various mechanisms, maintaining normal cardiac function.…”

Section: Regulatory Effects Of Protein Arginine Methyltransferase 1 O...mentioning

confidence: 99%

Role of protein arginine methyltransferase 1 in obesity‐related metabolic disorders: Research progress and implications

Xuan,

Zhang,

Song

et al. 2024

Diabetes Obesity Metabolism

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Obesity has become a major global problem that significantly confers an increased risk of developing life‐threatening complications, including type 2 diabetes mellitus, fatty liver disease and cardiovascular diseases. Protein arginine methyltransferases (PRMTs) are enzymes that catalyse the methylation of target proteins. They are ubiquitous in eukaryotes and regulate transcription, splicing, cell metabolism and RNA biology. As a key, epigenetically modified enzyme, protein arginine methyltransferase 1 (PRMT1) is involved in obesity‐related metabolic processes, such as lipid metabolism, the insulin signalling pathway, energy balance and inflammation, and plays an important role in the pathology of obesity‐related metabolic disorders. This review summarizes recent research on the role of PRMT1 in obesity‐related metabolic disorders. The primary objective was to comprehensively elucidate the functional role and regulatory mechanisms of PRMT1. Moreover, this study attempts to review the pathogenesis of PRMT1‐mediated obesity‐related metabolic disorders, thereby offering pivotal information for further studies and clinical treatment.

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“…Dysregulation of these proteins or arginine methylation has been linked to human cancers, neuromuscular disorders, cardiovascular diseases, and inflammatory conditions [62][63][64] Epigenetic machinery is often mutated or misexpressed in cancers, leading to the dysregulation of gene expression [65][66][67]. For example, DNA methylation of cancer cells is characteristically different than their normal counterparts.…”

Section: Chapter 1: Introductionmentioning

confidence: 99%

Investigating epigenetic therapies and combinations for the treatment of cancers

O'Brien

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I would also like to thank Dr. James Monaghan. James was willing to take on a PhD student working at a large pharmaceutical company. James was integral in navigating this process and always willing, and excited, to discuss data and provide advice. James has been a wonderful mentor throughout this entire process. I would like to also thank the members of my committee, Dr. Dori Woods and Dr. Erin Cram. They have guided me through multiple committee meetings.Finally, I would like to thank my colleagues at GSK. They have been a part of the thesis at every step of the way. From analyzing data, reading, editing drafts, and guidance, thank you to all of those that have helped me along the way.

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Relationship between protein arginine methyltransferase and cardiovascular disease (Review)

Cited by 8 publications

References 71 publications

Blood DNA methylation signature of diet quality and association with cardiometabolic traits

Blood DNA methylation signature of diet quality and association with cardiometabolic traits

Role of protein arginine methyltransferase 1 in obesity‐related metabolic disorders: Research progress and implications

Investigating epigenetic therapies and combinations for the treatment of cancers

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