Relationship between psoriasis and non‐alcoholic fatty liver disease – Updated systematic review and adjusted meta‐analysis

Phan, Kevin; Onggo, James Randolph; Charlton, Olivia; Smith, Saxon D

doi:10.1111/ajd.13015

Cited by 23 publications

(32 citation statements)

References 9 publications

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“…This study shows a prevalence of NAFLD of 42.3% in psoriatic patients-higher than the prevalence reported in the general population in Spain (25.8% to 33.4% in men and 20.3% in women) 14,23 , and consistent with other prevalence studies in people with psoriasis (44% to 65.6%) 6,7,15,24,25 . www.nature.com/scientificreports/…”

Section: Discussionsupporting

confidence: 90%

“…It is striking that the same comorbidities, especially those associated with metabolic disorders that can promote liver steatosis, have been associated with systemic inflammation in psoriasis. Moreover, specific proinflammatory mediators have been shown to cause a chronic inflammatory state in NAFLD, psoriasis, and metabolic syndrome 14,15 . These similarities could indicate a linked pathogenesis between psoriasis and NAFLD, with a potentially increased risk for advanced hepatic disease 12 .…”

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confidence: 99%

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Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients

Belinchón-Romero

Bellot

Romero‐Pérez

et al. 2021

Sci Rep

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Psoriasis and non-alcoholic fatty liver disease (NAFLD) are both inflammatory diseases. The study objective was to estimate the risk of NAFLD, non-alcoholic steatohepatitis, and liver fibrosis (by liver stiffness and liver biopsy) in patients with psoriasis and to determine the epidemiological, clinical, immunological (TNF-α, IL-2, IL-6, IL-12, IL-17, IL-23, and TGF-β) characteristics, and bacterial translocation. Of the 215 psoriatic patients included, 91 presented NAFLD (prevalence: 42.3%). Compared to patients with psoriasis alone, those with NAFLD were significantly more likely to have metabolic syndrome, diabetes, dyslipidemia, body mass index ≥ 30 kg/m2, homeostatic model assessment of insulin resistance ≥ 2.15, and greater psoriasis area severity index. NAFLD patients also had significantly higher levels of TNF-α (p = 0.002) and TGF-β (p = 0.007) and a higher prevalence of bacterial translocation (29.7% vs. 13.7%; p = 0.004). Liver stiffness measurement was over 7.8 kPa in 17.2% (15/87) of NAFLD patients; 13 of these underwent liver biopsy, and 5.7% (5/87) had liver fibrosis, while 1.1% (1/87) had advanced fibrosis or non-alcoholic steatohepatitis. In conclusion the prevalence of NAFLD in patients with psoriasis is high and associated with a higher prevalence of metabolic syndrome features, bacterial translocation and a higher pro-inflammatory state. It is worth mentioning that liver fibrosis and non-alcoholic steatohepatitis are not frequent in this population of patients.

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients

Belinchón-Romero

Bellot

Romero‐Pérez

et al. 2021

Sci Rep

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show abstract

“…In a large prospective population-based cohort study of 2292 participants, the prevalence of NAFLD was 46.2% among patients with psoriasis, and even higher when compared to the prevalence among patients without psoriasis (33.3%), even after adjustment for alcohol use, alanine aminotransferase levels, and metabolic syndrome components [151]. Two recent meta-analyses confirmed these data, estimating a two-fold greater risk of NAFLD in patients with psoriasis than non-psoriatic controls, and this risk appeared to be greater in patients with more severe psoriasis or with psoriatic arthritis [152,153]. Furthermore, in a retrospective cohort study on 29,957 children with psoriasis, a higher risk of obesity, metabolic syndrome, NAFLD, and elevated liver enzyme levels compared to non-psoriatic children was found [154].…”

Section: Resultsmentioning

confidence: 99%

“…PsoriasisIR is a common risk factor for both psoriasis and NAFLD. Patients with psoriasis have a 2-fold increased risk of suffering from NALFD [151,152,153,154,155,156]. Male sexual dysfunctionNAFLD is an emerging risk factor for the development of erectile dysfunction [200,201].…”

Section: Table A1mentioning

confidence: 99%

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Rosato

Masarone

Dallio

et al. 2019

IJERPH

104

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with extensive multi-organ involvement, whose extra-hepatic manifestations include type 2 diabetes mellitus, cardiovascular disease, obstructive sleep apnea, chronic kidney disease, osteoporosis, and polycystic ovarian syndrome. Recently, further evidence has given attention to pathological correlations not strictly related to metabolic disease, also incorporating in this broad spectrum of systemic involvement hypothyroidism, psoriasis, male sexual dysfunction, periodontitis, and urolithiasis. The most common cause of mortality in NAFLD is represented by cardiovascular disease, followed by liver-related complications. Therefore, clinicians should learn to screen and initiate treatment for these extra-hepatic manifestations, in order to provide appropriate multidisciplinary assessments and rigorous surveillance. This review evaluates the current evidence regarding extra-hepatic associations of NAFLD, focusing on the pathogenic hypothesis and the clinical implications.

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“…Autoimmune reactions triggered by chronic graft versus host disease in genetically predisposed individuals and microchimerism-induced allo-autoimmune reaction have been implicated. 5 Thus, in utero allo-autoimmune reactions may be a possible mechanism of leucoderma in our neonate.…”

Section: Spontaneously Regressing Acral Congenital Leucodermamentioning

confidence: 96%

Spontaneously regressing acral congenital leucoderma

2019

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Relationship between psoriasis and non‐alcoholic fatty liver disease – Updated systematic review and adjusted meta‐analysis

Cited by 23 publications

References 9 publications

Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients

Non-alcoholic fatty liver disease is associated with bacterial translocation and a higher inflammation response in psoriatic patients

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Spontaneously regressing acral congenital leucoderma

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