Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that selectively affects motor neurons. To date, there is no cure for ALS. It has been widely demonstrated how the use of AT can increase the independence and safety of patients improving their quality of life. Interventions based on the use of AT consist of aids to support residual capacities, increased autonomy and control of oneself and one's life, increased interactivity with the surrounding environment, increased participation in family and social life, maintaining a dignified standard of living, and at the same time decreasing the workload of the caregiver. The aim of the chapter is to provide an overview of the latest empirical evidence available on the use of AT-based programs for ALS people. Empirical data have demonstrated the effectiveness and adequacy of AT interventions. In conclusion, AT-based rehabilitation programs can be useful to promote the independence and quality of life of individuals with ALS.