Relationship between QRS duration and incident atrial fibrillation

Aeschbacher, Stefanie; O’Neal, Wesley T.; Krisai, Philipp; Loehr, Laura R.; Chen, Lin Y.; Alonso, Álvaro; Soliman, Elsayed Z.; Conen, David

doi:10.1016/j.ijcard.2018.03.050

Cited by 24 publications

(13 citation statements)

References 32 publications

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“…Most of the considered parameters have a clinical significance and a prognostic role with respect to the appearance of atrial fibrillation, sudden cardiovascular death, and major cardiovascular events [32][33][34], so their precise characterization is crucial. This work demonstrated, in a large contemporary primary population, that ECG is influenced by ageing, sex, cardiovascular diseases, and comorbidities but is difficult to be defined the weight of each of these conditions.…”

Section: Discussionmentioning

confidence: 99%

Combined Effects of Age and Comorbidities on Electrocardiographic Parameters in a Large Non-Selected Population

Giovanardi

Vernia

Tincani

et al. 2022

JCM

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Background: Previous studies have evaluated average electrocardiographic (ECG) values in healthy subjects or specific subpopulations. However, none have evaluated ECG average values in not selected populations, so we examined ECG changes with respect to age and sex in a large primary population. Methods: From digitized ECG stored from 2008 to 2021 in the Modena province, 130,471 patients were enrolled. Heart rate, P, QRS and T wave axis, P, QRS and T wave duration, PR interval, QTc, and frontal QRS-T angle were evaluated. Results: All ECG parameters showed a dependence on age, but only some of them with a straight-line correlation: QRS axis (p < 0.001, R2 = 0.991, r = 0.996), PR interval (p < 0.001, R2 = 0.978, r = 0.989), QTc (p < 0.001, R2 = 0.935, r = 0.967), and, in over 51.5 years old, QRS-T angle (p < 0.001, R2 = 0.979, r = 0.956). Differences between females and males and in different clinical settings were observed. Conclusions: ECG changes with ageing are explainable by intrinsic modifications of the heart and thorax and with the appearance of cardiovascular diseases and comorbidities. Age-related reference values were computed and applicable in clinical practice. Significant deviations from mean values and from Z-scores should be investigated.

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Section: Discussionmentioning

confidence: 99%

Combined Effects of Age and Comorbidities on Electrocardiographic Parameters in a Large Non-Selected Population

Giovanardi

Vernia

Tincani

et al. 2022

JCM

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“…In PRS analyses, we observed decreased risk of AF with increasing QT and QRS PRSs. This is an opposite direction of effect compared with epidemiological studies using directly measured ECG intervals where an increase in QRS or QT was associated with an increased risk of AF [75][76][77] . However, this relationship may be J-shaped as reported in a large study of over 280K individuals, and an increased risk of AF is also observed in patients with short QT syndrome compared to the general population 78,79 .…”

Section: Myocardial Fibrosis Impairs Cardiac Electrical Conduction Which Increases the Risk For Arrhythmogenesismentioning

confidence: 68%

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

Young¹,

Lahrouchi²,

Isaacs³

et al. 2021

Preprint

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The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization (QRS duration) and repolarization (JT interval). Abnormalities of the QT interval are associated with potentially fatal ventricular arrhythmia. We conducted genome-wide multi-ancestry analyses in >250,000 individuals and identified 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identified associations with Mendelian disease genes. Enrichments were observed in established pathways for QT and JT, with new genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast, connective tissue components and processes for cell growth and extracellular matrix interactions were significantly enriched for QRS. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlighted potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.

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“…30 QRS duration was an independent predictor of NOAF in this study, which was in concordance with previous findings. 31,32 The right and left atrium are composed of overlapping myocytes in the form of myocardial fibers that come together and create the atrial walls. Structural changes in the myocardium coexist in the atria and the ventricles, including cardiomyocyte hypertrophy and fibrosis; thus, QRS duration may be an indirect marker for left atrial disease.…”

Section: Commentsmentioning

confidence: 99%

Preoperative Electrocardiogram and Perioperative Methods for Predicting New-Onset Atrial Fibrillation During Lung Surgery

Jiang¹,

He²,

2021

Journal of Cardiothoracic and Vascular Anesthesia

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Relationship between QRS duration and incident atrial fibrillation

Abstract: In this large population-based study, QRSd was an independent predictor of incident AF among women, but not in men. Further studies are needed to better understand the underlying mechanisms.

Cited by 24 publications

References 32 publications

Combined Effects of Age and Comorbidities on Electrocardiographic Parameters in a Large Non-Selected Population

Combined Effects of Age and Comorbidities on Electrocardiographic Parameters in a Large Non-Selected Population

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

Preoperative Electrocardiogram and Perioperative Methods for Predicting New-Onset Atrial Fibrillation During Lung Surgery

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