Relationship between red blood cell antioxidant enzymatic system status and lipoperoxidation during the acute phase of malaria

Voluntary Exercise Protects Heart from Oxidative Stress in Diabetic Rats

“…Superoxide dismutase (SOD) activity was determined using a RASOD labratory kit (Randox Crumlin, UK) according to Delmas-Beauvieux et al 16 SOD activity was measured at 505 nm by a spectrophotometer (Pharmacia Biotech; England). In this method, xanthine and xanthine oxidase were used to generate superoxide radicals that react with 2-(4-iodophenyl)-3 (4-nitrophenol)-5-phenyl tetrazolium chloride (ITN) to form a red formazan dye.…”

Heme Impairs Prostaglandin E2 and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

“…It is widely know that severe falciparum malaria is linked to oxidative stress (23), inflammation (2,30,31) and high levels of hemolysis (3). To determine whether the same is true for vivax malaria, we measured plasma levels of indirect bilirubin and SOD-1 protein in patients with different clinical presentations of P. vivax infection.…”

“…During malaria infection, superoxide anions are thought to be the main form of ROS produced (23). In this context, the antioxidant enzyme Cu/Zn superoxide dismutase (SOD-1) is activated and may display an important role in the pathological oxidative injury.…”

Oxidative Stress in Human Health and Disease

“…In contrast, in low endemicity and low parasite exposure, because of lack or low host immune response, infection can lead to severe disease. It has been shown that whether an infection is uncomplicated or severe, there is a higher generation of ROS that is host and parasite derived (118). Host derived ROS generation arises from interaction of parasite ligands with host receptors during sporozoite invasion leading to phagocytosis and activation of NADPH dependent oxidases for ROS release (119).…”