Relationship between red blood cell–related indices and coronary artery calcification

Jin, Fulu; Chang, Xiansong; Wang, Xiaozhong; Xiong, Hui; Wang, Li; Zhang, Bo; Wang, Peiyu; Zhao, Liang

doi:10.1093/postmj/qgac003

Cited by 7 publications

(1 citation statement)

References 27 publications

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“…Red blood cells are the main particulate components of circulating blood, which play an important role in physiological hemodynamics and participate in the lesions of arterial wall. Currently, there is rare study focused on the relationship between RBC and vascular calci cation (20)(21). Meanwhile, vascular calci cation in patients with CKD is common, and EPO is widely applied for renal anemia in patients with CKD treatment.…”

Section: Discussionmentioning

confidence: 99%

Elevated red blood cell count levels are associated with increased vascular calcifcation in hemodialysis patients

zhang,

li,

et al. 2024

Preprint

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Introduction: Coronary artery calcification (CAC) is a predictor of poor survival and cardiovascular outcome in end-stage renal disease patients.We conducted this study to assess the risk factors for vascular calcification in maintenance hemodialysis patients. Methods: A total of 71 cases of HD patients who underwent hemodialysis in Hunan Provincial People's hospital from January 2022 to September 2022 were enrolled. The general clinical data and Laboratory results of the patients were collected.Chest CT examination was performed,and the CAC score was calculated. Results: CAC occurred in 41 ( 57.75%) of the 71 HD patients in the study.In the logistic regression analysis, CAC in these patients was significantly predicted by an diabetes (OR [95% CI]: 6.20 [1.37–28.11], P = 0.02) and red blood cell count (OR [95% CI]: 2.29 [1.05–5.02], P = 0.04).The ROC curve was applied to analyzing the red blood cell count; the area under the curve (AUC) was 0.66 (P = 0.02) and clinical diagnostic cutoff value = 2.99 (sensitivity = 75.6% and specificity = 56.7%) . Conclusion: The incidence rate of CAC in HD patients was high.Diabetes and red blood cell count were independent risk factors for CAC in HD patients.

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Section: Discussionmentioning

confidence: 99%

Elevated red blood cell count levels are associated with increased vascular calcifcation in hemodialysis patients

zhang,

li,

et al. 2024

Preprint

View full text Add to dashboard Cite

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Associations between per- and polyfluoroalkyl chemicals and abdominal aortic calcification in middle-aged and older adults

Yang,

Wang,

et al. 2024

Journal of Advanced Research

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Association between RDW-SD and prognosis across glycemic status in patients with dilated cardiomyopathy

Feng,

Huang,

Huang

et al. 2024

BMJ Open Diab Res Care

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IntroductionThe prognostic significance of red cell distribution width-SD (RDW-SD) as a promising inflammatory biomarker in individuals with non-ischemic dilated cardiomyopathy (DCM) and varying glycemic status remains unexplored.Research design and methodsPatients hospitalized for DCM in Fuwai Hospital from 2006 to 2021 were retrospectively included. The primary outcome encompassed all-cause mortality and heart transplantations. The multivariable Cox regression was used to evaluate the association between RDW-SD and outcomes in the overall DCM population, and among patients with normoglycemia (NG), pre-diabetes mellitus (pre-DM) and DM.ResultsAmong 1,102 patients with DCM, the median age was 48 years and 23.5% were women. In the overall DCM cohort, the RDW-SD was independently associated with the primary outcome (adjusted HR 1.29, 95% CI 1.15 to 1.45, p<0.001, per SD increase). When stratifying patients with glycemic status, the RDW-SD exhibited an independent association with outcome in patients with DCM with pre-DM and DM, the adjusted HRs were 1.48 (95% CI 1.21 to 1.79, p<0.001) and 1.30 (95% CI 1.06 to 1.60, p=0.011) per SD increase, respectively. However, in patients with DCM and NG, the prognostic value of RDW-SD was insignificant, with an adjusted HR of 1.20 per SD increase (95% CI: 0.97 to 1.48, p=0.101).ConclusionsRDW-SD was independently associated with the outcome in patients with DCM with pre-DM and DM, suggesting potential individualized therapeutic targets for this subset of patients with DCM.

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Relationship between red blood cell–related indices and coronary artery calcification

Cited by 7 publications

References 27 publications

Elevated red blood cell count levels are associated with increased vascular calcifcation in hemodialysis patients

Elevated red blood cell count levels are associated with increased vascular calcifcation in hemodialysis patients

Associations between per- and polyfluoroalkyl chemicals and abdominal aortic calcification in middle-aged and older adults

Association between RDW-SD and prognosis across glycemic status in patients with dilated cardiomyopathy

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