2004
DOI: 10.1182/blood-2003-04-1359
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Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas

Abstract: Although it has been suggested that REL is the critical target gene of 2p12-16 amplification in diffuse large B-cell lymphoma (DLBCL), little experimental evidence supports this notion. In the present study, we sought to evaluate the relationship between REL amplification and REL func-

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Cited by 89 publications
(90 citation statements)
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“…Gain of chromosome 2p has been identified as a recurrent alteration in 20% of DLBCL, (9)(10)(11)(12)(13)(14)(15) 50% of cHL, (16,17) and 3-47% of PMBCL cases. (11,14,15) In previous studies, CGH and FISH analyses were used as tools to investigate genomic alterations.…”
Section: Discussionmentioning
confidence: 99%
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“…Gain of chromosome 2p has been identified as a recurrent alteration in 20% of DLBCL, (9)(10)(11)(12)(13)(14)(15) 50% of cHL, (16,17) and 3-47% of PMBCL cases. (11,14,15) In previous studies, CGH and FISH analyses were used as tools to investigate genomic alterations.…”
Section: Discussionmentioning
confidence: 99%
“…(7) Amplification at the 2p arm has been reported in B-cell lymphomas, such as DLBCL, (9)(10)(11)(12)(13)(14)(15) classical Hodgkin's lymphoma (cHL), (16,17) follicular lymphoma (FL) (18) and primary mediastinal B-cell lymphoma (PMBCL). (11,14,15) The two candidate genes, REL and BCL11A, have been mapped within this 2p15 -16 amplicon.…”
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confidence: 99%
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“…With regard to these findings, gains in 2p16 were most frequent in patients who failed to achieve a CR. It is noteworthy that a gain in chromosome 2p has been identified as a recurrent alteration in 20% of patients DLBCL 12,[31][32][33][34][35][36][37] and is the most frequent CGH alteration in classic Hodgkin lymphoma (identified in 50% of patients). 38,39 The common recurrent region expands 4.2 Mb in 2p15-16.…”
Section: Discussionmentioning
confidence: 99%
“…Gene expression profiling results were analyzed first by principalcomponent analysis (PCA) using a list of 146 probe sets that represented 62 genes that are characteristic of ABC or GC signature. 33 This analysis identified 5 LBCL samples with an ABC cell signature and distinguished them from the 5 samples of LBCL with a GC signature (Fig. 1A).…”
Section: Gene Expression Analysismentioning
confidence: 99%