Relationship between representation of hindpaw and hindpaw barrel subfield (HBS) in layer IV of rat somatosensory cortex

Pearson, Phillip P.; Oladehin, Akinniran; Li, Cheng X.; Johnson, Eldridge F.; Weeden, Amanda M.; Daniel, Cynthia H.; Waters, Robert S.

doi:10.1097/00001756-199610020-00009

Cited by 12 publications

(10 citation statements)

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“…Rat: HbR and HbO forepaw maps each had similar topographic shapes ( Figure 5). This shape and orientation was similar to the anatomical forepaw representation in layer IV (Aangel et al, 1976;Dawson and Killackey, 1987;Pearson et al, 1996;Waters et al, 1995), but an order of magnitude larger. The average shape of the HbT map was more distorted due to apparent HbT changes within first and second order branches of surface veins and arteries.…”

Section: Shapesupporting

confidence: 75%

Temporal profiles and 2-dimensional oxy-, deoxy-, and total-hemoglobin somatosensory maps in rat versus mouse cortex

et al. 2007

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Section: Shapesupporting

confidence: 75%

Temporal profiles and 2-dimensional oxy-, deoxy-, and total-hemoglobin somatosensory maps in rat versus mouse cortex

et al. 2007

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“…To distinguish between these aggregates, the large posteriorly located barrels were designated as posterior-medial barrel subfield (PMBSF), and the more anteriorly located barrels were designated as the anterior lateral barrel subfield (ALBSF). Subsequent investigations identified additional clusters of barrels associated with the representation of the forepaw and hindpaw, designated forepaw barrel subfield (FBS) and hindpaw barrel subfield (HBS), respectively (Welker 1976; Dawson and Killackey 1987;Waters et al 1995;Pearson et al 1996). The rodent barrel field develops differentially during the first postnatal week, with the face barrels appearing on postnatal day three (P3), followed by forelimb barrels on P5 and hindlimb barrels on P6 (McCandlish et al 1989).…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice

Xin

et al. 2005

Somatosensory & Motor Research

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We measured the combined area of posterior medial barrel subfield (PMBSF) and anterior lateral barrel subfield (ALBSF) areas in four common inbred strains (C3H/HeJ, A /J, C57BL /6J, DBA/2J), B6D2F1, and ten recombinant inbred (RI) strains generated from C57BL/6J and DBA/2J progenitors (BXD) as an initial attempt to examine the genetic influences underlying natural variation in barrel field size in adult mice. These two subfields are associated with the representation of the whisker pad and sinus hairs on the contralateral face. Using cytochrome oxidase labeling to visualize the barrel field, we measured the size of the combined subfields in each mouse strain. We also measured body weight and brain weight in each strain. We report that DBA/2J mice have a larger combined PMBSF/ALBSF area (6.15 +/- 0.10 mm(2), n = 7) than C57BL /6J (5.48 +/- 0.13 mm(2), n = 10), C3H/HeJ (5.37 +/- 0.16 mm(2), n = 10), and A/J mice (5.04 +/- 0.09 mm(2), n = 15), despite the fact that DBA/2J mice have smaller average brain and body sizes. This finding may reflect dissociation between systems that control brain size with those that regulate barrel field area. In addition, BXD strains (average n = 4) and parental strains showed considerable and continuous variation in PMBSF/ALBSF area, suggesting that this trait is polygenic. Furthermore, brain, body, and cortex weights have heritable differences between inbred strains and among BXD strains. PMBSF/ALBSF pattern appears similar among inbred and BXD strains, suggesting that somatosensory patterning reflects a common plan of organization. This data is an important first step in the quantitative genetic analysis of the parcellation of neocortex into diverse cytoarchitectonic zones that vary widely within and between species, and in identifying the genetic factors underlying barrel field size using quantitative trait locus (QTL) analyses.

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“…SI is divided into granular, perigranular, and dysgranular zones based on anatomical and physiological measures (Chapin and Lin, ). Granular SI receives sensory input from the ventral posterior thalamic nucleus (VP), and, in rodents, the granular cortex associated with the representation of the whiskers, face, jaw, forepaw, and hindpaw has a barrel‐like cluster arrangement of cells in layer IV (Welker, ; Chapin and Lin, ; Waters et al, ; Pearson et al, ). These barrel regions receive cutaneous input from densely innervated sites in the periphery, and barrel neurons have small punctate receptive fields.…”

Section: Discussionmentioning

confidence: 99%

“…Cortical layer IV in rodent SI is characterized by regions of well-defined cell aggregates, called barrels, which are segregated into subfields associated with the representation of the mystacial vibrissae (Woolsey and Van Der Loos, 1970;Van Der Loos and Woolsey, 1973;Welker, 1976), forepaw (Welker, 1976;Chapin and Lin, 1984;Waters et al, 1995), and hindpaw (Pearson et al, 1996). Layer IV also contains nebulous regions devoid of barrel-like structures that are located immediately posterior to the forepaw barrel subfield (FBS) and are associated with the representation of the wrist, arm, shoulder, and trunk (Pearson et al, 1996). This relationship between barrel field structure and function makes barrel field cortex an attractive model system for studying connectivity between ipsilateral and contralateral SI cortices.…”

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Differential Pattern of Interhemispheric Connections Between Homotopic Layer V Regions in the Forelimb Representation in Rat Barrel Field Cortex

DeCosta-Fortune

Curry

et al. 2015

The Anatomical Record

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Layer V neurons in forelimb and shoulder representations in rat first somatosensory cortex (SI) project to the contralateral SI. However, few studies have addressed whether projections from specific subregions of the forelimb representation, namely forepaw, wrist, or forearm, terminate at homotopic sites in the contralateral SI. Neuroanatomical retrograde (cholera toxin B subunit [CT-B]) or anterograde (biodextran amine [BDA]) tracers were injected into physiologically identified sites in layer V in specific forelimb and/or shoulder representations in SI to examine the projection to contralateral SI in young adult rats (N 5 17). Injection and target sites were flattened and cut in a tangential plane to relate labeling to the body map or cut along a coronal plane to relate labeling to cortical layers. Results indicate that layer V neurons project to cortical laminae II-VI in contralateral SI, with the densest labeling in layer V followed by layer III. In contrast, layer V neurons send sparse projections to layer IV. Furthermore, layer V neurons in wrist, forearm, and shoulder project to homotopic sites in contralateral layer V, while neurons in the forepaw representation project largely to sites in perigranular and dysgranular cortex adjacent to their homotopic territory. Our results provide evidence for a differential pattern of interhemispheric projections from forelimb and shoulder representations to the opposite SI and a detailed description of areal and laminar projection patterns of layer V neurons in the SI forelimb and shoulder cortices. Anat Rec, 298:1885Rec, 298: -1902Rec, 298: , 2015. V C 2015 Wiley Periodicals, Inc.

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Relationship between representation of hindpaw and hindpaw barrel subfield (HBS) in layer IV of rat somatosensory cortex

Cited by 12 publications

References 0 publications

Temporal profiles and 2-dimensional oxy-, deoxy-, and total-hemoglobin somatosensory maps in rat versus mouse cortex

Temporal profiles and 2-dimensional oxy-, deoxy-, and total-hemoglobin somatosensory maps in rat versus mouse cortex

Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice

Differential Pattern of Interhemispheric Connections Between Homotopic Layer V Regions in the Forelimb Representation in Rat Barrel Field Cortex

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