Relationship Between Resistin Levels and Sepsis Among Children Under 12 Years of Age: A Case Control Study

Saboktakin, Lida; Bilan, Nemat; Behbahan, Afshin Ghalehgolab; Poorebrahim, Sadegh

doi:10.3389/fped.2019.00355

Cited by 14 publications

(11 citation statements)

References 41 publications

(45 reference statements)

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“…Some studies on adult and neonatal patients have reported elevated serum levels during inflammation and infection. The few studies conducted on newborns have suggested that this marker could be an indicator of EOS, but its diagnostic value proved to be less than that of CRP and the cut-off value could not be established with accuracy due to several factors such as control group and number of days since the first sign of sepsis [ 125 , 126 ]. Some biomarkers such as sTREM-1 (human triggering receptor expressed on myeloid cells-1), pentraxin-3 and pro-adrenomedullin, which were found to have high values in infected adults and children, failed to prove their role in neonatal EOS [ 127 ].…”

Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

et al. 2020

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Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first 72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up to 9.8% live births in low resource settings, generating a high mortality rate, especially in extremely low birth weight neonates. Clinical signs are nonspecific, leading to a late diagnosis and high mortality. Currently, there are several markers used for sepsis evaluation, such as hematological indices, acute phase reactants, cytokines, which by themselves do not show acceptable sensitivity and specificity for the diagnosis of EOS in neonates. Newer and more selective markers have surfaced recently, such as presepsin and endocan, but they are currently only in the experimental research stages. This comprehensive review article is based on the role of biomarkers currently in use or in the research phase from a basic, translational, and clinical viewpoint that helps us to improve the quality of neonatal early-onset sepsis diagnosis and management.

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Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

et al. 2020

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“…This is also in line with our data in both human and murine sepsis, in which the biological processes enriched in the CEACAM1 gene co-expression network were assigned to negative regulation of T cell activation. In addition, the strong correlation between expression levels of RETN and CEACAM1 in the acute sepsis phase could reflect the deleterious clinical outcomes in this phase 43 .…”

Section: Discussionmentioning

confidence: 99%

The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution

Alhamdan,

Koutsogiannaki,

Yuki

2024

Preprint

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Recognizing immune dysregulation as a hallmark of sepsis pathophysiology, leukocytes have attracted major attention of investigation. While adult and pediatric sepsis are clinically distinct, their immunological delineation remains limited. Breakthrough of single cell technologies facilitated the characterization of immune signatures. We tackled to delineate immunological profiles of pediatric sepsis at a single-cell level by analyzing blood samples from six septic children, at both acute and recovery phases, and four healthy children. 16 single-cell transcriptomic datasets (96,156 cells) were analyzed and compared to adult sepsis dataset. We showed a unique shift in neutrophil subpopulations and functions between acute and recovery phases, along with examining the regulatory role of resistin. Neutrophil signatures were comparable between adult and pediatric sepsis. Innate-like CD4 T cells were predominantly and uniquely observed in acute phase of pediatric sepsis. Our study provides a thorough and comprehensive understanding of immune dysregulation in pediatric sepsis.

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“…При активации эндотелиальных клеток цитокинами наблюдается быстрое повышение (в течение 1-6 ч) уровня sICAM-1 в сыворотке крови, что делает его маркером системного воспаления. В нас тоящее время существуют разногласия относительно полезности этого маркера для диагностики EOS, поскольку некоторые авторы предложили sICAM-1 в качестве ценного маркера только в первые 4 дня жизни, а другие отметили аналогичные или даже более высокие уровни у здоровых новорожденных в первые 5 дней [40,41]; 5) програнулин -аутокринный фактор роста из 593 аминокислот, который регулирует сигнальную систему TNF/TNFR, может предсказывать сепсис и СПОН у новорожденных > 34 недель беременности [42]; 6) неоптерин -биохимический маркер иммунной активности, повышение которого определяется при клеточно-опосредованном иммунном ответе; 7) резистин (FIZZ3) -белок, богатый цистеином, который играет спорную физиологическую роль в ожирении и инсулинорезистентности и повышается при системном воспалительном ответе у новорожденных, детей и взрослых, однако его диагностическую ценность еще предстоит узнать [43,44]; 8) пресепсин (ПСП) -это белок, являющийся N-концевым фрагментом рецептора макрофагов CD14 [45]. Механизм образования ПСП связан с бактериальным фагоцитозом и расщеплением CD14 лизосомальными ферментами.…”

Section: биомаркеры системного воспаленияunclassified

Multiple organ dysfunction syndrome prediction in newborn children

Golomidov¹,

Grigoryev

Мозес

et al. 2022

Innovacionnaâ medicina Kubani

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There are several directions for predicting multiple organ dysfunction syndrome (MODS), but almost all of them are poorly tested in neonatology. This review is presented to indicate the problem of the condition severity objectification of newborns and the possibility of predicting the development of MODS. Scales for assessing the severity of MODS in critically ill children have been developed and used since the end of the last century, but their validation in the newborns faces certain difficulties. Prognostic nosospecific scales: NICHD (National Institute of Child Health and Human Development) calculator, CRIB II (Clinical Risk Index for Babies), SNAPPE-II (Score for Neonatal Acute Physiology with Perinatal Extension II) are used in neonatology, however their comparison in this category of patients has not been carried out.Theoretical and practical issues of the short-term and long-term prediction of the MODS onset and its outcomes in newborns is a promising area of neonatology, since it allows a doctor to be warned about an impending catastrophe and opens a “window of opportunity” for timely correction of treatment tactics and complications prevention. Obtaining different phenotypes of critical illness and predicting their outcomes in children may have good predictive potential, but such studies have not been conducted in newborns. A promising direction in predicting MODS is the identification of biomarkers of inflammation, among which endocan, cluster of differentiation 64, cluster of differentiation molecules 11b, “pancreatic stone protein” (PSP), soluble intercellular adhesionmolecule-1 (sICAM-1), progranulin, neopterin, resistin (FIZZ3, presepsin (PSP)) carry a good potential, but their effectiveness in neonatology is still to be investigated.Thus, the prediction of MODS in children and newborns remains an unresolved problem. At the same time, several promising scientific directions are actively being developed today, which may lead to a significant breakthrough in predicting MODS in neonatology.

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Relationship Between Resistin Levels and Sepsis Among Children Under 12 Years of Age: A Case Control Study

Cited by 14 publications

References 41 publications

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution

Multiple organ dysfunction syndrome prediction in newborn children

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